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Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.

Pietras K, Pahler J, Bergers G, Hanahan D.

PLoS Med. 2008 Jan 29;5(1):e19. doi: 10.1371/journal.pmed.0050019.


Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model.

Jain RK, Lahdenranta J, Fukumura D.

PLoS Med. 2008 Jan 29;5(1):e24. doi: 10.1371/journal.pmed.0050024. No abstract available.


PDGF receptors as targets in tumor treatment.

Ostman A, Heldin CH.

Adv Cancer Res. 2007;97:247-74. Review.


HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.

Murata T, Mizushima H, Chinen I, Moribe H, Yagi S, Hoffman RM, Kimura T, Yoshino K, Ueda Y, Enomoto T, Mekada E.

Cancer Res. 2011 Nov 1;71(21):6633-42. doi: 10.1158/0008-5472.CAN-11-0034. Epub 2011 Oct 18.


Imatinib mesylate inhibits the proliferation-stimulating effect of human lung cancer-associated stromal fibroblasts on lung cancer cells.

Kinoshita K, Nakagawa K, Hamada J, Hida Y, Tada M, Kondo S, Moriuchi T.

Int J Oncol. 2010 Oct;37(4):869-77.


Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content.

McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, Bucana C, Ellis LM.

J Clin Invest. 2007 Aug;117(8):2114-22.


Anti-stromal therapy with imatinib inhibits growth and metastasis of gastric carcinoma in an orthotopic nude mouse model.

Sumida T, Kitadai Y, Shinagawa K, Tanaka M, Kodama M, Ohnishi M, Ohara E, Tanaka S, Yasui W, Chayama K.

Int J Cancer. 2011 May 1;128(9):2050-62. doi: 10.1002/ijc.25812.


The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB.

Shimizu A, O'Brien KP, Sjöblom T, Pietras K, Buchdunger E, Collins VP, Heldin CH, Dumanski JP, Ostman A.

Cancer Res. 1999 Aug 1;59(15):3719-23.


Targeting stromal cells for the treatment of platelet-derived growth factor C-induced hepatocellular carcinogenesis.

Campbell JS, Johnson MM, Bauer RL, Hudkins KL, Gilbertson DG, Riehle KJ, Yeh MM, Alpers CE, Fausto N.

Differentiation. 2007 Nov;75(9):843-52.


Targeting PDGF receptors in cancer--rationales and proof of concept clinical trials.

George D.

Adv Exp Med Biol. 2003;532:141-51. Review.


Stroma-directed imatinib therapy impairs the tumor-promoting effect of bone marrow-derived mesenchymal stem cells in an orthotopic transplantation model of colon cancer.

Shinagawa K, Kitadai Y, Tanaka M, Sumida T, Onoyama M, Ohnishi M, Ohara E, Higashi Y, Tanaka S, Yasui W, Chayama K.

Int J Cancer. 2013 Feb 15;132(4):813-23. doi: 10.1002/ijc.27735. Epub 2012 Aug 6.


Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer.

Taeger J, Moser C, Hellerbrand C, Mycielska ME, Glockzin G, Schlitt HJ, Geissler EK, Stoeltzing O, Lang SA.

Mol Cancer Ther. 2011 Nov;10(11):2157-67. doi: 10.1158/1535-7163.MCT-11-0312. Epub 2011 Sep 1.


Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors.

Sennino B, Kuhnert F, Tabruyn SP, Mancuso MR, Hu-Lowe DD, Kuo CJ, McDonald DM.

Cancer Res. 2009 May 15;69(10):4527-36. doi: 10.1158/0008-5472.CAN-08-3779. Epub 2009 Apr 28.


PDGF BB induces VEGF secretion in ovarian cancer.

Matei D, Kelich S, Cao L, Menning N, Emerson RE, Rao J, Jeng MH, Sledge GW.

Cancer Biol Ther. 2007 Dec;6(12):1951-9. Epub 2007 Sep 1.


Platelet-derived growth factor-D and Rho GTPases regulate recruitment of cancer-associated fibroblasts in cholangiocarcinoma.

Cadamuro M, Nardo G, Indraccolo S, Dall'olmo L, Sambado L, Moserle L, Franceschet I, Colledan M, Massani M, Stecca T, Bassi N, Morton S, Spirli C, Fiorotto R, Fabris L, Strazzabosco M.

Hepatology. 2013 Sep;58(3):1042-53. doi: 10.1002/hep.26384. Epub 2013 Jul 22.


Platelet-derived growth factor receptors: a therapeutic target in solid tumors.

George D.

Semin Oncol. 2001 Oct;28(5 Suppl 17):27-33. Review.


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