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The nuclear affairs of PTEN.

Planchon SM, Waite KA, Eng C.

J Cell Sci. 2008 Feb 1;121(Pt 3):249-53. doi: 10.1242/jcs.022459. Review.


Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade.

Liu JL, Mao Z, LaFortune TA, Alonso MM, Gallick GE, Fueyo J, Yung WK.

Cancer Res. 2007 Nov 15;67(22):11054-63.


Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.

Beckham TH, Cheng JC, Lu P, Marrison ST, Norris JS, Liu X.

PLoS One. 2013 Oct 1;8(10):e76593. doi: 10.1371/journal.pone.0076593. eCollection 2013.


PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression.

Chang CJ, Mulholland DJ, Valamehr B, Mosessian S, Sellers WR, Wu H.

Mol Cell Biol. 2008 May;28(10):3281-9. doi: 10.1128/MCB.00310-08. Epub 2008 Mar 10.


Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

Gil A, Andrés-Pons A, Fernández E, Valiente M, Torres J, Cervera J, Pulido R.

Mol Biol Cell. 2006 Sep;17(9):4002-13. Epub 2006 Jun 28.


Ubiquitination regulates PTEN nuclear import and tumor suppression.

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Yang H, Pavletich NP, Carver BS, Cordon-Cardo C, Erdjument-Bromage H, Tempst P, Chi SG, Kim HJ, Misteli T, Jiang X, Pandolfi PP.

Cell. 2007 Jan 12;128(1):141-56.


PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1.

Radu A, Neubauer V, Akagi T, Hanafusa H, Georgescu MM.

Mol Cell Biol. 2003 Sep;23(17):6139-49.


PTEN: a new guardian of the genome.

Yin Y, Shen WH.

Oncogene. 2008 Sep 18;27(41):5443-53. doi: 10.1038/onc.2008.241. Review.


Cytoplasmic p27Kip1 counteracts the pro-apoptotic function of the open conformation of PTEN by retention and destabilization of PTEN outside of the nucleus.

Andrés-Pons A, Gil A, Oliver MD, Sotelo NS, Pulido R.

Cell Signal. 2012 Feb;24(2):577-87. doi: 10.1016/j.cellsig.2011.10.012. Epub 2011 Oct 20.


A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth.

Denning G, Jean-Joseph B, Prince C, Durden DL, Vogt PK.

Oncogene. 2007 Jun 7;26(27):3930-40. Epub 2007 Jan 8.


PTEN function: the long and the short of it.

Hopkins BD, Hodakoski C, Barrows D, Mense SM, Parsons RE.

Trends Biochem Sci. 2014 Apr;39(4):183-90. doi: 10.1016/j.tibs.2014.02.006. Epub 2014 Mar 18. Review.


Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure.

Gong L, Govan JM, Evans EB, Dai H, Wang E, Lee SW, Lin HK, Lazar AJ, Mills GB, Lin SY.

Cell Cycle. 2015;14(14):2323-32. doi: 10.1080/15384101.2015.1044174.


Essential role for nuclear PTEN in maintaining chromosomal integrity.

Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y.

Cell. 2007 Jan 12;128(1):157-70.


A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity.

Gil A, Rodríguez-Escudero I, Stumpf M, Molina M, Cid VJ, Pulido R.

PLoS One. 2015 Apr 15;10(4):e0119287. doi: 10.1371/journal.pone.0119287. eCollection 2015.


PTEN enters the nuclear age.

Baker SJ.

Cell. 2007 Jan 12;128(1):25-8. Review.


Mechanistic insights into maintenance of high p53 acetylation by PTEN.

Li AG, Piluso LG, Cai X, Wei G, Sellers WR, Liu X.

Mol Cell. 2006 Aug;23(4):575-87.


ATP modulates PTEN subcellular localization in multiple cancer cell lines.

Lobo GP, Waite KA, Planchon SM, Romigh T, Houghton JA, Eng C.

Hum Mol Genet. 2008 Sep 15;17(18):2877-85. doi: 10.1093/hmg/ddn185. Epub 2008 Jun 25.


PTEN: a novel anti-oncogenic function independent of phosphatase activity.

Okumura K, Zhao M, DePinho RA, Furnari FB, Cavenee WK.

Cell Cycle. 2005 Apr;4(4):540-2. Epub 2005 Apr 21. Review.


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