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Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

Peck-Palmer OM, Unsinger J, Chang KC, Davis CG, McDunn JE, Hotchkiss RS.

J Leukoc Biol. 2008 Apr;83(4):1009-18. doi: 10.1189/jlb.0807528. Epub 2008 Jan 22.


Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice.

Hotchkiss RS, Swanson PE, Cobb JP, Jacobson A, Buchman TG, Karl IE.

Crit Care Med. 1997 Aug;25(8):1298-307.


The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis.

Unsinger J, Herndon JM, Davis CG, Muenzer JT, Hotchkiss RS, Ferguson TA.

J Immunol. 2006 Dec 1;177(11):7968-73.


p53-dependent and -independent pathways of apoptotic cell death in sepsis.

Hotchkiss RS, Tinsley KW, Hui JJ, Chang KC, Swanson PE, Drewry AM, Buchman TG, Karl IE.

J Immunol. 2000 Apr 1;164(7):3675-80.


Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis.

Schwulst SJ, Grayson MH, DiPasco PJ, Davis CG, Brahmbhatt TS, Ferguson TA, Hotchkiss RS.

J Immunol. 2006 Jul 1;177(1):557-65.


Silencing of fas-associated death domain protects mice from septic lung inflammation and apoptosis.

Matsuda N, Yamamoto S, Takano K, Kageyama S, Kurobe Y, Yoshihara Y, Takano Y, Hattori Y.

Am J Respir Crit Care Med. 2009 May 1;179(9):806-15. doi: 10.1164/rccm.200804-534OC. Epub 2009 Feb 6.


TLR2 and caspase-8 are essential for group B Streptococcus-induced apoptosis in microglia.

Lehnardt S, Wennekamp J, Freyer D, Liedtke C, Krueger C, Nitsch R, Bechmann I, Weber JR, Henneke P.

J Immunol. 2007 Nov 1;179(9):6134-43.


Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways.

Hotchkiss RS, Osmon SB, Chang KC, Wagner TH, Coopersmith CM, Karl IE.

J Immunol. 2005 Apr 15;174(8):5110-8.


Lack of MyD88 protects the immunodeficient host against fatal lung inflammation triggered by the opportunistic bacteria Burkholderia cenocepacia.

Ventura GM, Balloy V, Ramphal R, Khun H, Huerre M, Ryffel B, Plotkowski MC, Chignard M, Si-Tahar M.

J Immunol. 2009 Jul 1;183(1):670-6. doi: 10.4049/jimmunol.0801497. Epub 2009 Jun 17.


Enhancement of NF-kappaB activation in lymphocytes prevents T cell apoptosis and improves survival in murine sepsis.

Groesdonk HV, Wagner F, Hoffarth B, Georgieff M, Senftleben U.

J Immunol. 2007 Dec 15;179(12):8083-9.


TLR2-dependent MyD88 signaling contributes to early host defense in murine Enterococcus faecium peritonitis.

Leendertse M, Willems RJ, Giebelen IA, van den Pangaart PS, Wiersinga WJ, de Vos AF, Florquin S, Bonten MJ, van der Poll T.

J Immunol. 2008 Apr 1;180(7):4865-74.


Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis.

Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, Zollner KM, Buchman TG, Korsmeyer SJ, Karl IE.

J Immunol. 1999 Apr 1;162(7):4148-56.


Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells.

Tinsley KW, Grayson MH, Swanson PE, Drewry AM, Chang KC, Karl IE, Hotchkiss RS.

J Immunol. 2003 Jul 15;171(2):909-14.


Endotoxin tolerance: selective alterations in gene expression and protection against lymphocyte death.

Melo ES, Goloubkova T, Barbeiro DF, Gorj√£o R, Vasconcelos D, Szabo C, Curi R, de Lima Salgado TM, Velasco IT, Soriano FG.

Immunobiology. 2010 Jun;215(6):435-42. doi: 10.1016/j.imbio.2009.09.002. Epub 2009 Oct 2.


Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis.

Muenzer JT, Davis CG, Dunne BS, Unsinger J, Dunne WM, Hotchkiss RS.

Shock. 2006 Dec;26(6):565-70.


Heat shock protein 60, via MyD88 innate signaling, protects B cells from apoptosis, spontaneous and induced.

Cohen-Sfady M, Pevsner-Fischer M, Margalit R, Cohen IR.

J Immunol. 2009 Jul 15;183(2):890-6. doi: 10.4049/jimmunol.0804238. Epub 2009 Jun 26.


Signaling through MyD88 regulates leukocyte recruitment after brain injury.

Babcock AA, Toft-Hansen H, Owens T.

J Immunol. 2008 Nov 1;181(9):6481-90.


B lymphocytes undergo apoptosis because of FcgammaRIIb stress response to infection: a novel mechanism of cell death in sepsis.

Pinheiro-da-Silva F, Chiamolera M, Charles N, Kanamaru Y, Velasco IT, Benhamou M, Monteiro RC.

Shock. 2006 Jan;25(1):61-5.


Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte.

Hotchkiss RS, Chang KC, Swanson PE, Tinsley KW, Hui JJ, Klender P, Xanthoudakis S, Roy S, Black C, Grimm E, Aspiotis R, Han Y, Nicholson DW, Karl IE.

Nat Immunol. 2000 Dec;1(6):496-501.


TLR4 and MyD88 control protection and pulmonary granulocytic recruitment in a murine intranasal RSV immunization and challenge model.

Cyr SL, Angers I, Guillot L, Stoica-Popescu I, Lussier M, Qureshi S, Burt DS, Ward BJ.

Vaccine. 2009 Jan 14;27(3):421-30. doi: 10.1016/j.vaccine.2008.10.073. Epub 2008 Nov 14.


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