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Items: 1 to 20 of 120

1.

A quantitative analysis of kinase inhibitor selectivity.

Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, Faraoni R, Floyd M, Hunt JP, Lockhart DJ, Milanov ZV, Morrison MJ, Pallares G, Patel HK, Pritchard S, Wodicka LM, Zarrinkar PP.

Nat Biotechnol. 2008 Jan;26(1):127-32. doi: 10.1038/nbt1358.

PMID:
18183025
2.

Trends in kinase selectivity: insights for target class-focused library screening.

Posy SL, Hermsmeier MA, Vaccaro W, Ott KH, Todderud G, Lippy JS, Trainor GL, Loughney DA, Johnson SR.

J Med Chem. 2011 Jan 13;54(1):54-66. doi: 10.1021/jm101195a. Epub 2010 Dec 3.

PMID:
21128601
3.

Kinase-kernel models: accurate in silico screening of 4 million compounds across the entire human kinome.

Martin E, Mukherjee P.

J Chem Inf Model. 2012 Jan 23;52(1):156-70. doi: 10.1021/ci200314j. Epub 2012 Jan 6.

PMID:
22133092
4.

Chemical genomic and proteomic methods for determining kinase inhibitor selectivity.

Krishnamurty R, Maly DJ.

Comb Chem High Throughput Screen. 2007 Sep;10(8):652-66. Review.

PMID:
18045078
5.

Chemical fragments as foundations for understanding target space and activity prediction.

Sutherland JJ, Higgs RE, Watson I, Vieth M.

J Med Chem. 2008 May 8;51(9):2689-700. doi: 10.1021/jm701399f. Epub 2008 Apr 4.

PMID:
18386916
6.

Predicting kinase selectivity profiles using Free-Wilson QSAR analysis.

Sciabola S, Stanton RV, Wittkopp S, Wildman S, Moshinsky D, Potluri S, Xi H.

J Chem Inf Model. 2008 Sep;48(9):1851-67. doi: 10.1021/ci800138n. Epub 2008 Aug 22.

PMID:
18717582
7.

Selectivity of kinase inhibitor fragments.

Bamborough P, Brown MJ, Christopher JA, Chung CW, Mellor GW.

J Med Chem. 2011 Jul 28;54(14):5131-43. doi: 10.1021/jm200349b. Epub 2011 Jun 23.

PMID:
21699136
8.

PhosphoPOINT: a comprehensive human kinase interactome and phospho-protein database.

Yang CY, Chang CH, Yu YL, Lin TC, Lee SA, Yen CC, Yang JM, Lai JM, Hong YR, Tseng TL, Chao KM, Huang CY.

Bioinformatics. 2008 Aug 15;24(16):i14-20. doi: 10.1093/bioinformatics/btn297.

PMID:
18689816
9.

Prediction of specificity-determining residues for small-molecule kinase inhibitors.

Caffrey DR, Lunney EA, Moshinsky DJ.

BMC Bioinformatics. 2008 Nov 25;9:491. doi: 10.1186/1471-2105-9-491.

10.

A small molecule-kinase interaction map for clinical kinase inhibitors.

Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, LĂ©lias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ.

Nat Biotechnol. 2005 Mar;23(3):329-36. Epub 2005 Feb 13.

11.

Protein kinase inhibitors: structural insights into selectivity.

Thaimattam R, Banerjee R, Miglani R, Iqbal J.

Curr Pharm Des. 2007;13(27):2751-65. Review.

PMID:
17897021
12.

On the origins of enzyme inhibitor selectivity and promiscuity: a case study of protein kinase binding to staurosporine.

Tanramluk D, Schreyer A, Pitt WR, Blundell TL.

Chem Biol Drug Des. 2009 Jul;74(1):16-24. doi: 10.1111/j.1747-0285.2009.00832.x.

13.

Gini coefficient: a new way to express selectivity of kinase inhibitors against a family of kinases.

Graczyk PP.

J Med Chem. 2007 Nov 15;50(23):5773-9. Epub 2007 Oct 19.

PMID:
17948979
14.
15.

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

Xing L, Shieh HS, Selness SR, Devraj RV, Walker JK, Devadas B, Hope HR, Compton RP, Schindler JF, Hirsch JL, Benson AG, Kurumbail RG, Stegeman RA, Williams JM, Broadus RM, Walden Z, Monahan JB.

Biochemistry. 2009 Jul 14;48(27):6402-11. doi: 10.1021/bi900655f.

PMID:
19496616
16.

Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.

Sundstrom TJ, Anderson AC, Wright DL.

Org Biomol Chem. 2009 Mar 7;7(5):840-50. doi: 10.1039/b819067b. Epub 2009 Jan 8. Review.

PMID:
19225663
17.

High-throughput biochemical kinase selectivity assays: panel development and screening applications.

Card A, Caldwell C, Min H, Lokchander B, Hualin Xi, Sciabola S, Kamath AV, Clugston SL, Tschantz WR, Leyu Wang, Moshinsky DJ.

J Biomol Screen. 2009 Jan;14(1):31-42. doi: 10.1177/1087057108326663. Epub 2008 Dec 10.

PMID:
19073965
18.

Toward a pharmacophore for kinase frequent hitters.

Aronov AM, Murcko MA.

J Med Chem. 2004 Nov 4;47(23):5616-9.

PMID:
15509160
19.

Kinase-likeness and kinase-privileged fragments: toward virtual polypharmacology.

Aronov AM, McClain B, Moody CS, Murcko MA.

J Med Chem. 2008 Mar 13;51(5):1214-22. doi: 10.1021/jm701021b. Epub 2008 Feb 21.

PMID:
18288794
20.

Kinase selectivity profiling by inhibitor affinity chromatography.

Valsasina B, Kalisz HM, Isacchi A.

Expert Rev Proteomics. 2004 Oct;1(3):303-15. Review.

PMID:
15966827

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