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Nuclear export of NF90 to stabilize IL-2 mRNA is mediated by AKT-dependent phosphorylation at Ser647 in response to CD28 costimulation.

Pei Y, Zhu P, Dang Y, Wu J, Yang X, Wan B, Liu JO, Yi Q, Yu L.

J Immunol. 2008 Jan 1;180(1):222-9.


IL-2 mRNA stabilization upon PMA stimulation is dependent on NF90-Ser647 phosphorylation by protein kinase CbetaI.

Zhu P, Jiang W, Cao L, Yu W, Pei Y, Yang X, Wan B, Liu JO, Yi Q, Yu L.

J Immunol. 2010 Nov 1;185(9):5140-9. doi: 10.4049/jimmunol.1000849. Epub 2010 Sep 24.


Molecular mechanisms underlying differential contribution of CD28 versus non-CD28 costimulatory molecules to IL-2 promoter activation.

Zhou XY, Yashiro-Ohtani Y, Nakahira M, Park WR, Abe R, Hamaoka T, Naramura M, Gu H, Fujiwara H.

J Immunol. 2002 Apr 15;168(8):3847-54.


Cutting edge: CD28-mediated transcriptional and posttranscriptional regulation of IL-2 expression are controlled through different signaling pathways.

Sanchez-Lockhart M, Marin E, Graf B, Abe R, Harada Y, Sedwick CE, Miller J.

J Immunol. 2004 Dec 15;173(12):7120-4.


Nuclear export of NF90 is required for interleukin-2 mRNA stabilization.

Shim J, Lim H, R Yates J, Karin M.

Mol Cell. 2002 Dec;10(6):1331-44.


Enhanced NFATc1 nuclear occupancy causes T cell activation independent of CD28 costimulation.

Pan M, Winslow MM, Chen L, Kuo A, Felsher D, Crabtree GR.

J Immunol. 2007 Apr 1;178(7):4315-21.


Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.

Janardhan SV, Praveen K, Marks R, Gajewski TF.

PLoS One. 2011;6(9):e24931. doi: 10.1371/journal.pone.0024931. Epub 2011 Sep 19.


Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.

Kane LP, Andres PG, Howland KC, Abbas AK, Weiss A.

Nat Immunol. 2001 Jan;2(1):37-44.


Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta.

Elliott MR, Shanks RA, Khan IU, Brooks JW, Burkett PJ, Nelson BJ, Kyttaris V, Juang YT, Tsokos GC, Kammer GM.

J Immunol. 2004 Jun 15;172(12):7804-12.


cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: a potential role for MEF2.

Liopeta K, Boubali S, Virgilio L, Thyphronitis G, Mavrothalassitis G, Dimitracopoulos G, Paliogianni F.

Mol Immunol. 2009 Jan;46(3):345-54. doi: 10.1016/j.molimm.2008.10.025. Epub 2008 Dec 5.


Protein kinase B/Akt signals impair Th17 differentiation and support natural regulatory T cell function and induced regulatory T cell formation.

Pierau M, Engelmann S, Reinhold D, Lapp T, Schraven B, Bommhardt UH.

J Immunol. 2009 Nov 15;183(10):6124-34. doi: 10.4049/jimmunol.0900246. Epub 2009 Oct 19.


RNA binding and phosphorylation determine the intracellular distribution of nuclear factors 90 and 110.

Parrott AM, Walsh MR, Reichman TW, Mathews MB.

J Mol Biol. 2005 Apr 29;348(2):281-93.


Phosphorylation of each of the distal three tyrosines of the CD28 cytoplasmic tail is required for CD28-induced T cell IL-2 secretion.

Teng JM, King PD, Sadra A, Liu X, Han A, Selvakumar A, August A, Dupont B.

Tissue Antigens. 1996 Oct;48(4 Pt 1):255-64.


Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.

Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11796-801. Epub 2002 Aug 23. Erratum in: Proc Natl Acad Sci U S A 2002 Nov 12;99(23):15245.

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