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Items: 1 to 20 of 103

1.

Psoriasis is associated with increased beta-defensin genomic copy number.

Hollox EJ, Huffmeier U, Zeeuwen PL, Palla R, Lascorz J, Rodijk-Olthuis D, van de Kerkhof PC, Traupe H, de Jongh G, den Heijer M, Reis A, Armour JA, Schalkwijk J.

Nat Genet. 2008 Jan;40(1):23-5. Epub 2007 Dec 2.

2.

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon.

Fellermann K, Stange DE, Schaeffeler E, Schmalzl H, Wehkamp J, Bevins CL, Reinisch W, Teml A, Schwab M, Lichter P, Radlwimmer B, Stange EF.

Am J Hum Genet. 2006 Sep;79(3):439-48. Epub 2006 Jul 12.

3.

Copy-number analysis goes more than skin deep.

McCarroll SA.

Nat Genet. 2008 Jan;40(1):5-6. No abstract available.

PMID:
18163125
4.

Relevance of α-defensins (HNP1-3) and defensin β-1 in diabetes.

Németh BC, Várkonyi T, Somogyvári F, Lengyel C, Fehértemplomi K, Nyiraty S, Kempler P, Mándi Y.

World J Gastroenterol. 2014 Jul 21;20(27):9128-37. doi: 10.3748/wjg.v20.i27.9128.

5.

Copy number variation of beta-defensins and relevance to disease.

Hollox EJ.

Cytogenet Genome Res. 2008;123(1-4):148-55. doi: 10.1159/000184702. Epub 2009 Mar 11. Review.

PMID:
19287149
6.

Association of β-defensin copy number and psoriasis in three cohorts of European origin.

Stuart PE, Hüffmeier U, Nair RP, Palla R, Tejasvi T, Schalkwijk J, Elder JT, Reis A, Armour JAL.

J Invest Dermatol. 2012 Oct;132(10):2407-2413. doi: 10.1038/jid.2012.191. Epub 2012 Jun 28.

7.

Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.

Janssens W, Nuytten H, Dupont LJ, Van Eldere J, Vermeire S, Lambrechts D, Nackaerts K, Decramer M, Cassiman JJ, Cuppens H.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):163-9. doi: 10.1164/rccm.200905-0767OC. Epub 2010 Apr 8.

PMID:
20378733
8.

Genetic variants of the copy number polymorphic beta-defensin locus are associated with sporadic prostate cancer.

Huse K, Taudien S, Groth M, Rosenstiel P, Szafranski K, Hiller M, Hampe J, Junker K, Schubert J, Schreiber S, Birkenmeier G, Krawczak M, Platzer M.

Tumour Biol. 2008;29(2):83-92. doi: 10.1159/000135688. Epub 2008 Jun 2.

PMID:
18515986
9.

Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors.

Hüffmeier U, Bergboer JG, Becker T, Armour JA, Traupe H, Estivill X, Riveira-Munoz E, Mössner R, Reich K, Kurrat W, Wienker TF, Schalkwijk J, Zeeuwen PL, Reis A.

J Invest Dermatol. 2010 Apr;130(4):979-84. doi: 10.1038/jid.2009.385. Epub 2009 Dec 17.

10.

No Evidence for Association of β-Defensin Genomic Copy Number with HIV Susceptibility, HIV Load during Clinical Latency, or Progression to AIDS.

Abujaber R, Shea PR, McLaren PJ, Lakhi S, Gilmour J, Allen S, Fellay J, Hollox EJ; IAVI Africa HIV Prevention Partnership, Swiss HIV Cohort Study.

Ann Hum Genet. 2017 Jan;81(1):27-34. doi: 10.1111/ahg.12182.

PMID:
28084001
12.

High-resolution mapping of the 8p23.1 beta-defensin cluster reveals strictly concordant copy number variation of all genes.

Groth M, Szafranski K, Taudien S, Huse K, Mueller O, Rosenstiel P, Nygren AO, Schreiber S, Birkenmeier G, Platzer M.

Hum Mutat. 2008 Oct;29(10):1247-54. doi: 10.1002/humu.20751.

PMID:
18470942
13.

Association of higher DEFB4 genomic copy number with Crohn's disease.

Bentley RW, Pearson J, Gearry RB, Barclay ML, McKinney C, Merriman TR, Roberts RL.

Am J Gastroenterol. 2010 Feb;105(2):354-9. doi: 10.1038/ajg.2009.582. Epub 2009 Oct 6.

PMID:
19809410
14.

High Copy Numbers of β-Defensin Cluster on 8p23.1, Confer Genetic Susceptibility, and Modulate the Physical Course of Hidradenitis Suppurativa/Acne Inversa.

Giamarellos-Bourboulis EJ, Platzer M, Karagiannidis I, Kanni T, Nikolakis G, Ulrich J, Bellutti M, Gollnick H, Bauer M, Zouboulis CC, Huse K.

J Invest Dermatol. 2016 Aug;136(8):1592-8. doi: 10.1016/j.jid.2016.04.021. Epub 2016 May 7.

15.

Beta-defensins and Crohn's disease: confusion from counting copies.

Hollox EJ.

Am J Gastroenterol. 2010 Feb;105(2):360-2. doi: 10.1038/ajg.2009.573.

PMID:
20139874
16.

Screening of copy number polymorphisms in human beta-defensin genes using modified real-time quantitative PCR.

Chen Q, Book M, Fang X, Hoeft A, Stuber F.

J Immunol Methods. 2006 Jan 20;308(1-2):231-40. Epub 2005 Dec 15.

PMID:
16380128
17.

Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.

Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO.

PLoS One. 2014 May 27;9(5):e98269. doi: 10.1371/journal.pone.0098269. eCollection 2014.

18.

Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.

Hollox EJ, Davies J, Griesenbach U, Burgess J, Alton EW, Armour JA.

J Negat Results Biomed. 2005 Dec 7;4:9.

19.

Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma.

Wain LV, Odenthal-Hesse L, Abujaber R, Sayers I, Beardsmore C, Gaillard EA, Chappell S, Dogaru CM, McKeever T, Guetta-Baranes T, Kalsheker N, Kuehni CE, Hall IP, Tobin MD, Hollox EJ.

PLoS One. 2014 Jan 3;9(1):e84192. doi: 10.1371/journal.pone.0084192. eCollection 2014.

20.

Determination of beta-defensin genomic copy number in different populations: a comparison of three methods.

Fode P, Jespersgaard C, Hardwick RJ, Bogle H, Theisen M, Dodoo D, Lenicek M, Vitek L, Vieira A, Freitas J, Andersen PS, Hollox EJ.

PLoS One. 2011 Feb 22;6(2):e16768. doi: 10.1371/journal.pone.0016768.

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