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Items: 1 to 20 of 108

1.

Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.

Lelievre V, Seksenyan A, Nobuta H, Yong WH, Chhith S, Niewiadomski P, Cohen JR, Dong H, Flores A, Liau LM, Kornblum HI, Scott MP, Waschek JA.

Dev Biol. 2008 Jan 1;313(1):359-70. Epub 2007 Nov 26.

2.

Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.

3.

Interaction of PACAP with Sonic hedgehog reveals complex regulation of the hedgehog pathway by PKA.

Niewiadomski P, Zhujiang A, Youssef M, Waschek JA.

Cell Signal. 2013 Nov;25(11):2222-30. doi: 10.1016/j.cellsig.2013.07.012. Epub 2013 Jul 18.

4.

Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation.

Nicot A, Lelièvre V, Tam J, Waschek JA, DiCicco-Bloom E.

J Neurosci. 2002 Nov 1;22(21):9244-54.

5.

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.

Uziel T, Zindy F, Xie S, Lee Y, Forget A, Magdaleno S, Rehg JE, Calabrese C, Solecki D, Eberhart CG, Sherr SE, Plimmer S, Clifford SC, Hatten ME, McKinnon PJ, Gilbertson RJ, Curran T, Sherr CJ, Roussel MF.

Genes Dev. 2005 Nov 15;19(22):2656-67. Epub 2005 Oct 31.

6.

Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.

Sasai K, Romer JT, Kimura H, Eberhart DE, Rice DS, Curran T.

Cancer Res. 2007 Apr 15;67(8):3871-7. Epub 2007 Apr 5.

7.

Insulin-like growth factor 2 is required for progression to advanced medulloblastoma in patched1 heterozygous mice.

Corcoran RB, Bachar Raveh T, Barakat MT, Lee EY, Scott MP.

Cancer Res. 2008 Nov 1;68(21):8788-95. doi: 10.1158/0008-5472.CAN-08-2135.

8.

Structural and morphometric comparison of the molar teeth in pre-eruptive developmental stage of PACAP-deficient and wild-type mice.

Sandor B, Fintor K, Felszeghy S, Juhasz T, Reglodi D, Mark L, Kiss P, Jungling A, Fulop BD, Nagy AD, Hashimoto H, Zakany R, Nagy A, Tamas A.

J Mol Neurosci. 2014 Nov;54(3):331-41. doi: 10.1007/s12031-014-0392-6. Epub 2014 Aug 12.

PMID:
25112419
9.

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma.

Zinke J, Schneider FT, Harter PN, Thom S, Ziegler N, Toftgård R, Plate KH, Liebner S.

Mol Cancer. 2015 Feb 3;14:17. doi: 10.1186/s12943-015-0294-4.

10.

Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.

Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, Sonntag J, Rüngeler E, Hache H, Wierling C, Nietfeld W, Lehrach H, Frischauf A, Schwartz-Albiez R, Aberger F, Korf U.

PLoS One. 2013 Jun 10;8(6):e65403. doi: 10.1371/journal.pone.0065403. Print 2013.

11.

Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.

Koudijs MJ, den Broeder MJ, Groot E, van Eeden FJ.

BMC Dev Biol. 2008 Feb 19;8:15. doi: 10.1186/1471-213X-8-15.

12.

Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.

Taniguchi E, Cho MJ, Arenkiel BR, Hansen MS, Rivera OJ, McCleish AT, Qualman SJ, Guttridge DC, Scott MP, Capecchi MR, Keller C.

Pediatr Blood Cancer. 2009 Aug;53(2):136-44. doi: 10.1002/pbc.21968.

13.

Gli1 is important for medulloblastoma formation in Ptc1+/- mice.

Kimura H, Stephen D, Joyner A, Curran T.

Oncogene. 2005 Jun 9;24(25):4026-36.

PMID:
15806168
14.

Two tumor suppressors, p27Kip1 and patched-1, collaborate to prevent medulloblastoma.

Ayrault O, Zindy F, Rehg J, Sherr CJ, Roussel MF.

Mol Cancer Res. 2009 Jan;7(1):33-40. doi: 10.1158/1541-7786.MCR-08-0369.

15.

Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration.

Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, Blond F, Delhomme N, Hahn M, Reifenberger J, Reifenberger G, Lichter P.

PLoS Genet. 2012;8(3):e1002572. doi: 10.1371/journal.pgen.1002572. Epub 2012 Mar 15.

16.

Histone deacetylase 6 represents a novel drug target in the oncogenic Hedgehog signaling pathway.

Dhanyamraju PK, Holz PS, Finkernagel F, Fendrich V, Lauth M.

Mol Cancer Ther. 2015 Mar;14(3):727-39. doi: 10.1158/1535-7163.MCT-14-0481. Epub 2014 Dec 31.

17.

A mouse model for medulloblastoma and basal cell nevus syndrome.

Corcoran RB, Scott MP.

J Neurooncol. 2001 Jul;53(3):307-18. Review.

PMID:
11718263
18.

Hedgehog-signaling is upregulated in non-producing human adrenal adenomas and antagonism of hedgehog-signaling inhibits proliferation of NCI-H295R cells and an immortalized primary human adrenal cell line.

Werminghaus P, Haase M, Hornsby PJ, Schinner S, Schott M, Malendowicz LK, Lammers BJ, Goretzki PE, Müller-Mattheis V, Markus Giessing, Willenberg HS.

J Steroid Biochem Mol Biol. 2014 Jan;139:7-15. doi: 10.1016/j.jsbmb.2013.09.007. Epub 2013 Sep 21.

PMID:
24063979
19.

Several PATCHED1 missense mutations display activity in patched1-deficient fibroblasts.

Bailey EC, Milenkovic L, Scott MP, Collawn JF, Johnson RL.

J Biol Chem. 2002 Sep 13;277(37):33632-40. Epub 2002 Jun 18.

20.

Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.

Palmer CJ, Galan-Caridad JM, Weisberg SP, Lei L, Esquilin JM, Croft GF, Wainwright B, Canoll P, Owens DM, Reizis B.

Cancer Res. 2014 Oct 15;74(20):5914-24. doi: 10.1158/0008-5472.CAN-14-0834. Epub 2014 Aug 27.

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