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The yeast Slx5-Slx8 DNA integrity complex displays ubiquitin ligase activity.

Ii T, Fung J, Mullen JR, Brill SJ.

Cell Cycle. 2007 Nov 15;6(22):2800-9. Epub 2007 Aug 13.


Activation of the Slx5-Slx8 ubiquitin ligase by poly-small ubiquitin-like modifier conjugates.

Mullen JR, Brill SJ.

J Biol Chem. 2008 Jul 18;283(29):19912-21. doi: 10.1074/jbc.M802690200. Epub 2008 May 22.


Purification of the yeast Slx5-Slx8 protein complex and characterization of its DNA-binding activity.

Yang L, Mullen JR, Brill SJ.

Nucleic Acids Res. 2006;34(19):5541-51. Epub 2006 Oct 4.


Stimulation of in vitro sumoylation by Slx5-Slx8: evidence for a functional interaction with the SUMO pathway.

Ii T, Mullen JR, Slagle CE, Brill SJ.

DNA Repair (Amst). 2007 Nov;6(11):1679-91. Epub 2007 Jul 31.


A Lysine Desert Protects a Novel Domain in the Slx5-Slx8 SUMO Targeted Ub Ligase To Maintain Sumoylation Levels in Saccharomyces cerevisiae.

Sharma P, Mullen JR, Li M, Zaratiegui M, Bunting SF, Brill SJ.

Genetics. 2017 Aug;206(4):1807-1821. doi: 10.1534/genetics.117.202697. Epub 2017 May 26.


The SUMO-targeted ubiquitin ligase subunit Slx5 resides in nuclear foci and at sites of DNA breaks.

Cook CE, Hochstrasser M, Kerscher O.

Cell Cycle. 2009 Apr 1;8(7):1080-9. Epub 2009 Apr 9.


The yeast Hex3.Slx8 heterodimer is a ubiquitin ligase stimulated by substrate sumoylation.

Xie Y, Kerscher O, Kroetz MB, McConchie HF, Sung P, Hochstrasser M.

J Biol Chem. 2007 Nov 23;282(47):34176-84. Epub 2007 Sep 11.


The Slx5-Slx8 complex affects sumoylation of DNA repair proteins and negatively regulates recombination.

Burgess RC, Rahman S, Lisby M, Rothstein R, Zhao X.

Mol Cell Biol. 2007 Sep;27(17):6153-62. Epub 2007 Jun 25.


Wss1 is a SUMO-dependent isopeptidase that interacts genetically with the Slx5-Slx8 SUMO-targeted ubiquitin ligase.

Mullen JR, Chen CF, Brill SJ.

Mol Cell Biol. 2010 Aug;30(15):3737-48. doi: 10.1128/MCB.01649-09. Epub 2010 Jun 1.


A SUMO-targeted ubiquitin ligase is involved in the degradation of the nuclear pool of the SUMO E3 ligase Siz1.

Westerbeck JW, Pasupala N, Guillotte M, Szymanski E, Matson BC, Esteban C, Kerscher O.

Mol Biol Cell. 2014 Jan;25(1):1-16. doi: 10.1091/mbc.E13-05-0291. Epub 2013 Nov 6.


Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells.

Böhm S, Mihalevic MJ, Casal MA, Bernstein KA.

DNA Repair (Amst). 2015 Feb;26:1-14. doi: 10.1016/j.dnarep.2014.12.004. Epub 2014 Dec 26.


Suppression of genomic instability by SLX5 and SLX8 in Saccharomyces cerevisiae.

Zhang C, Roberts TM, Yang J, Desai R, Brown GW.

DNA Repair (Amst). 2006 Mar 7;5(3):336-46. Epub 2005 Dec 1.


Quality control of a transcriptional regulator by SUMO-targeted degradation.

Wang Z, Prelich G.

Mol Cell Biol. 2009 Apr;29(7):1694-706. doi: 10.1128/MCB.01470-08. Epub 2009 Jan 12.


Genetic analysis connects SLX5 and SLX8 to the SUMO pathway in Saccharomyces cerevisiae.

Wang Z, Jones GM, Prelich G.

Genetics. 2006 Mar;172(3):1499-509. Epub 2005 Dec 30.


PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.

Horigome C, Bustard DE, Marcomini I, Delgoshaie N, Tsai-Pflugfelder M, Cobb JA, Gasser SM.

Genes Dev. 2016 Apr 15;30(8):931-45. doi: 10.1101/gad.277665.116. Epub 2016 Apr 7.


Functional targeting of DNA damage to a nuclear pore-associated SUMO-dependent ubiquitin ligase.

Nagai S, Dubrana K, Tsai-Pflugfelder M, Davidson MB, Roberts TM, Brown GW, Varela E, Hediger F, Gasser SM, Krogan NJ.

Science. 2008 Oct 24;322(5901):597-602. doi: 10.1126/science.1162790.


Genetic evidence that polysumoylation bypasses the need for a SUMO-targeted Ub ligase.

Mullen JR, Das M, Brill SJ.

Genetics. 2011 Jan;187(1):73-87. doi: 10.1534/genetics.110.124347. Epub 2010 Nov 8.


Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements.

Albuquerque CP, Wang G, Lee NS, Kolodner RD, Putnam CD, Zhou H.

PLoS Genet. 2013;9(8):e1003670. doi: 10.1371/journal.pgen.1003670. Epub 2013 Aug 1. Erratum in: PLoS Genet. 2016 Aug;12(8):e1006302.


SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase toward a short-lived transcription factor.

Xie Y, Rubenstein EM, Matt T, Hochstrasser M.

Genes Dev. 2010 May;24(9):893-903. doi: 10.1101/gad.1906510. Epub 2010 Apr 13.


STUbL-mediated degradation of the transcription factor MATα2 requires degradation elements that coincide with corepressor binding sites.

Hickey CM, Hochstrasser M.

Mol Biol Cell. 2015 Oct 1;26(19):3401-12. doi: 10.1091/mbc.E15-06-0436. Epub 2015 Aug 5.

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