Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 136


Orai1 subunit stoichiometry of the mammalian CRAC channel pore.

Mignen O, Thompson JL, Shuttleworth TJ.

J Physiol. 2008 Jan 15;586(2):419-25.


Graded activation of CRAC channel by binding of different numbers of STIM1 to Orai1 subunits.

Li Z, Liu L, Deng Y, Ji W, Du W, Xu P, Chen L, Xu T.

Cell Res. 2011 Feb;21(2):305-15. doi: 10.1038/cr.2010.131.


Orai1 is an essential pore subunit of the CRAC channel.

Prakriya M, Feske S, Gwack Y, Srikanth S, Rao A, Hogan PG.

Nature. 2006 Sep 14;443(7108):230-3.


The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits.

Mignen O, Thompson JL, Shuttleworth TJ.

J Physiol. 2009 Sep 1;587(Pt 17):4181-97. doi: 10.1113/jphysiol.2009.174193.


STIM1-Orai1 interactions and Orai1 conformational changes revealed by live-cell FRET microscopy.

Navarro-Borelly L, Somasundaram A, Yamashita M, Ren D, Miller RJ, Prakriya M.

J Physiol. 2008 Nov 15;586(22):5383-401. doi: 10.1113/jphysiol.2008.162503.


Properties of Orai1 mediated store-operated current depend on the expression levels of STIM1 and Orai1 proteins.

Scrimgeour N, Litjens T, Ma L, Barritt GJ, Rychkov GY.

J Physiol. 2009 Jun 15;587(Pt 12):2903-18. doi: 10.1113/jphysiol.2009.170662.


A Ca2(+ )release-activated Ca2(+) (CRAC) modulatory domain (CMD) within STIM1 mediates fast Ca2(+)-dependent inactivation of ORAI1 channels.

Derler I, Fahrner M, Muik M, Lackner B, Schindl R, Groschner K, Romanin C.

J Biol Chem. 2009 Sep 11;284(37):24933-8. doi: 10.1074/jbc.C109.024083.


Atomic force microscopy (AFM) imaging suggests that stromal interaction molecule 1 (STIM1) binds to Orai1 with sixfold symmetry.

Balasuriya D, Srivats S, Murrell-Lagnado RD, Edwardson JM.

FEBS Lett. 2014 Aug 25;588(17):2874-80. doi: 10.1016/j.febslet.2014.06.054.


STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1.

Park CY, Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.

Cell. 2009 Mar 6;136(5):876-90. doi: 10.1016/j.cell.2009.02.014.


Differential roles of the C and N termini of Orai1 protein in interacting with stromal interaction molecule 1 (STIM1) for Ca2+ release-activated Ca2+ (CRAC) channel activation.

Zheng H, Zhou MH, Hu C, Kuo E, Peng X, Hu J, Kuo L, Zhang SL.

J Biol Chem. 2013 Apr 19;288(16):11263-72. doi: 10.1074/jbc.M113.450254.


Voltage gating at the selectivity filter of the Ca2+ release-activated Ca2+ channel induced by mutation of the Orai1 protein.

Spassova MA, Hewavitharana T, Fandino RA, Kaya A, Tanaka J, Gill DL.

J Biol Chem. 2008 May 30;283(22):14938-45.


ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond.

Feske S.

Immunol Rev. 2009 Sep;231(1):189-209. doi: 10.1111/j.1600-065X.2009.00818.x. Review.


On the stoichiometry of resting and activated CRAC channels.

Chen L, Xu T.

Curr Top Membr. 2013;71:95-108. doi: 10.1016/B978-0-12-407870-3.00004-4. Review.


Stoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).

Hoover PJ, Lewis RS.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13299-304. doi: 10.1073/pnas.1101664108.


CRAC channelopathies.

Feske S.

Pflugers Arch. 2010 Jul;460(2):417-35. doi: 10.1007/s00424-009-0777-5. Review.


The intracellular loop of Orai1 plays a central role in fast inactivation of Ca2+ release-activated Ca2+ channels.

Srikanth S, Jung HJ, Ribalet B, Gwack Y.

J Biol Chem. 2010 Feb 12;285(7):5066-75. doi: 10.1074/jbc.M109.072736.


Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components.

Ong HL, Cheng KT, Liu X, Bandyopadhyay BC, Paria BC, Soboloff J, Pani B, Gwack Y, Srikanth S, Singh BB, Gill DL, Ambudkar IS.

J Biol Chem. 2007 Mar 23;282(12):9105-16. Erratum in: J Biol Chem. 2007 Sep 14;282(37):27556. Gill, Donald [corrected to Gill, Donald L].

Items per page

Supplemental Content

Support Center