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Items: 1 to 20 of 95

1.

Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion.

Regard JB, Kataoka H, Cano DA, Camerer E, Yin L, Zheng YW, Scanlan TS, Hebrok M, Coughlin SR.

J Clin Invest. 2007 Dec;117(12):4034-43.

2.

3-iodothyronamine differentially modulates α-2A-adrenergic receptor-mediated signaling.

Dinter J, Mühlhaus J, Jacobi SF, Wienchol CL, Cöster M, Meister J, Hoefig CS, Müller A, Köhrle J, Grüters A, Krude H, Mittag J, Schöneberg T, Kleinau G, Biebermann H.

J Mol Endocrinol. 2015 Jun;54(3):205-16. doi: 10.1530/JME-15-0003. Epub 2015 Apr 15.

PMID:
25878061
3.

Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.

Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93. doi: 10.1073/pnas.1319378112. Epub 2015 Feb 18.

4.

Insulin secretion stimulated by L-arginine and its metabolite L-ornithine depends on Gα(i2).

Leiss V, Flockerzie K, Novakovic A, Rath M, Schönsiegel A, Birnbaumer L, Schürmann A, Harteneck C, Nürnberg B.

Am J Physiol Endocrinol Metab. 2014 Nov 1;307(9):E800-12. doi: 10.1152/ajpendo.00337.2014. Epub 2014 Sep 9.

5.

Blockade of receptor-activated G(i) signaling in osteoblasts in vivo leads to site-specific increases in cortical and cancellous bone formation.

Millard SM, Louie AM, Wattanachanya L, Wronski TJ, Conklin BR, Nissenson RA.

J Bone Miner Res. 2011 Apr;26(4):822-32. doi: 10.1002/jbmr.273.

6.

Gs-DREADD Knock-In Mice for Tissue-Specific, Temporal Stimulation of Cyclic AMP Signaling.

Akhmedov D, Mendoza-Rodriguez MG, Rajendran K, Rossi M, Wess J, Berdeaux R.

Mol Cell Biol. 2017 Apr 14;37(9). pii: e00584-16. doi: 10.1128/MCB.00584-16. Print 2017 May 1.

7.

Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing.

Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA.

J Bone Miner Res. 2015 Oct;30(10):1896-904. doi: 10.1002/jbmr.2540. Epub 2015 May 14.

8.

The G protein Gi1 exhibits basal coupling but not preassembly with G protein-coupled receptors.

Bondar A, Lazar J.

J Biol Chem. 2017 Jun 9;292(23):9690-9698. doi: 10.1074/jbc.M116.768127. Epub 2017 Apr 24.

PMID:
28438833
9.

Augmented glucose-induced insulin release in mice lacking G(o2), but not G(o1) or G(i) proteins.

Wang Y, Park S, Bajpayee NS, Nagaoka Y, Boulay G, Birnbaumer L, Jiang M.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1693-8. doi: 10.1073/pnas.1018903108. Epub 2011 Jan 10.

11.

Subthreshold α₂-adrenergic activation counteracts glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion.

Pan M, Yang G, Cui X, Yang SN.

Exp Diabetes Res. 2011;2011:604989. doi: 10.1155/2011/604989. Epub 2010 Dec 27. Erratum in: Exp Diabetes Res. 2011;2011:319202.

12.

The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets.

Vivot K, Moullé VS, Zarrouki B, Tremblay C, Mancini AD, Maachi H, Ghislain J, Poitout V.

Mol Metab. 2016 Aug 26;5(10):988-96. doi: 10.1016/j.molmet.2016.08.010. eCollection 2016 Oct.

13.

G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies.

Nakamura K, Salomonis N, Tomoda K, Yamanaka S, Conklin BR.

PLoS One. 2009 Nov 10;4(11):e7780. doi: 10.1371/journal.pone.0007780.

14.

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.

Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT.

Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15.

15.
16.

Arsenic activates endothelin-1 Gi protein-coupled receptor signaling to inhibit stem cell differentiation in adipogenesis.

Klei LR, Garciafigueroa DY, Barchowsky A.

Toxicol Sci. 2013 Feb;131(2):512-20. doi: 10.1093/toxsci/kfs323. Epub 2012 Nov 14.

17.
18.

Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes.

Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ.

J Biol Chem. 2003 Dec 12;278(50):50010-23. Epub 2003 Sep 30.

19.

Evolving insights regarding mechanisms for the inhibition of insulin release by norepinephrine and heterotrimeric G proteins.

Straub SG, Sharp GW.

Am J Physiol Cell Physiol. 2012 Jun 15;302(12):C1687-98. doi: 10.1152/ajpcell.00282.2011. Epub 2012 Apr 4. Review.

20.

Gi-mediated translocation of GLUT4 is independent of p85/p110alpha and p110gamma phosphoinositide 3-kinases but might involve the activation of Akt kinase.

Wang L, Hayashi H, Kishi K, Huang L, Hagi A, Tamaoka K, Hawkins PT, Ebina Y.

Biochem J. 2000 Feb 1;345 Pt 3:543-55.

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