Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 105

1.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.

2.

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.

Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z, He C.

FEBS Lett. 2008 Oct 15;582(23-24):3313-9. doi: 10.1016/j.febslet.2008.08.019. Epub 2008 Sep 5.

3.

Hypothalamic FTO is associated with the regulation of energy intake not feeding reward.

Olszewski PK, Fredriksson R, Olszewska AM, Stephansson O, Alsiö J, Radomska KJ, Levine AS, Schiöth HB.

BMC Neurosci. 2009 Oct 27;10:129. doi: 10.1186/1471-2202-10-129.

4.

Regulation of Fto/Ftm gene expression in mice and humans.

Stratigopoulos G, Padilla SL, LeDuc CA, Watson E, Hattersley AT, McCarthy MI, Zeltser LM, Chung WK, Leibel RL.

Am J Physiol Regul Integr Comp Physiol. 2008 Apr;294(4):R1185-96. doi: 10.1152/ajpregu.00839.2007. Epub 2008 Feb 6. Erratum in: Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1360-3.

5.

FTO levels affect RNA modification and the transcriptome.

Berulava T, Ziehe M, Klein-Hitpass L, Mladenov E, Thomale J, Rüther U, Horsthemke B.

Eur J Hum Genet. 2013 Mar;21(3):317-23. doi: 10.1038/ejhg.2012.168. Epub 2012 Aug 8.

6.

Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner.

Pitman RT, Fong JT, Billman P, Puri N.

PLoS One. 2012;7(6):e38444. doi: 10.1371/journal.pone.0038444. Epub 2012 Jun 4.

7.

FTO expression is regulated by availability of essential amino acids.

Cheung MK, Gulati P, O'Rahilly S, Yeo GS.

Int J Obes (Lond). 2013 May;37(5):744-7. doi: 10.1038/ijo.2012.77. Epub 2012 May 22.

PMID:
22614055
8.

FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting.

McTaggart JS, Lee S, Iberl M, Church C, Cox RD, Ashcroft FM.

PLoS One. 2011;6(11):e27968. doi: 10.1371/journal.pone.0027968. Epub 2011 Nov 30.

9.

Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance.

Olszewski PK, Radomska KJ, Ghimire K, Klockars A, Ingman C, Olszewska AM, Fredriksson R, Levine AS, Schiöth HB.

Physiol Behav. 2011 May 3;103(2):248-53. doi: 10.1016/j.physbeh.2011.01.022. Epub 2011 Feb 2.

PMID:
21295049
10.

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Tung YC, Ayuso E, Shan X, Bosch F, O'Rahilly S, Coll AP, Yeo GS.

PLoS One. 2010 Jan 19;5(1):e8771. doi: 10.1371/journal.pone.0008771.

11.

Changes in gene expression associated with FTO overexpression in mice.

Merkestein M, McTaggart JS, Lee S, Kramer HB, McMurray F, Lafond M, Boutens L, Cox R, Ashcroft FM.

PLoS One. 2014 May 19;9(5):e97162. doi: 10.1371/journal.pone.0097162. eCollection 2014 May 19.

12.

The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.

Speakman JR.

Curr Obes Rep. 2015 Mar;4(1):73-91. doi: 10.1007/s13679-015-0143-1. Review.

PMID:
26627093
13.

Fasting induced cytoplasmic Fto expression in some neurons of rat hypothalamus.

Vujovic P, Stamenkovic S, Jasnic N, Lakic I, Djurasevic SF, Cvijic G, Djordjevic J.

PLoS One. 2013 May 6;8(5):e63694. doi: 10.1371/journal.pone.0063694. Print 2013.

14.

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate.

Ma M, Harding HP, O'Rahilly S, Ron D, Yeo GS.

Biochem J. 2012 Jun 1;444(2):183-7. doi: 10.1042/BJ20120065.

PMID:
22435707
15.

The obesity-associated Fto gene is a transcriptional coactivator.

Wu Q, Saunders RA, Szkudlarek-Mikho M, Serna Ide L, Chin KV.

Biochem Biophys Res Commun. 2010 Oct 22;401(3):390-5. doi: 10.1016/j.bbrc.2010.09.064. Epub 2010 Sep 19.

16.

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD.

PLoS Genet. 2009 Aug;5(8):e1000599. doi: 10.1371/journal.pgen.1000599. Epub 2009 Aug 14.

17.

Obesity-associated variants within FTO form long-range functional connections with IRX3.

Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA.

Nature. 2014 Mar 20;507(7492):371-5. doi: 10.1038/nature13138. Epub 2014 Mar 12.

18.

FTO and obesity: mechanisms of association.

Zhao X, Yang Y, Sun BF, Zhao YL, Yang YG.

Curr Diab Rep. 2014;14(5):486. doi: 10.1007/s11892-014-0486-0. Review.

PMID:
24627050
19.

Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway.

Rask-Andersen M, Almén MS, Olausen HR, Olszewski PK, Eriksson J, Chavan RA, Levine AS, Fredriksson R, Schiöth HB.

BMC Neurosci. 2011 Nov 16;12:117. doi: 10.1186/1471-2202-12-117.

20.

Fat mass- and obesity-associated gene Fto affects the dietary response in mouse white adipose tissue.

Ronkainen J, Huusko TJ, Soininen R, Mondini E, Cinti F, Mäkelä KA, Kovalainen M, Herzig KH, Järvelin MR, Sebert S, Savolainen MJ, Salonurmi T.

Sci Rep. 2015 Mar 18;5:9233. doi: 10.1038/srep09233.

Supplemental Content

Support Center