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Items: 1 to 20 of 286

1.

The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation.

Beeton C, Smith BJ, Sabo JK, Crossley G, Nugent D, Khaytin I, Chi V, Chandy KG, Pennington MW, Norton RS.

J Biol Chem. 2008 Jan 11;283(2):988-97. Epub 2007 Nov 5.

2.

Role of disulfide bonds in the structure and potassium channel blocking activity of ShK toxin.

Pennington MW, Lanigan MD, Kalman K, Mahnir VM, Rauer H, McVaugh CT, Behm D, Donaldson D, Chandy KG, Kem WR, Norton RS.

Biochemistry. 1999 Nov 2;38(44):14549-58.

PMID:
10545177
3.

Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3.

Lanigan MD, Kalman K, Lefievre Y, Pennington MW, Chandy KG, Norton RS.

Biochemistry. 2002 Oct 8;41(40):11963-71.

PMID:
12356296
4.
5.

Designed peptide analogues of the potassium channel blocker ShK toxin.

Lanigan MD, Pennington MW, Lefievre Y, Rauer H, Norton RS.

Biochemistry. 2001 Dec 25;40(51):15528-37.

PMID:
11747428
6.

Potassium channel blockade by the sea anemone toxin ShK for the treatment of multiple sclerosis and other autoimmune diseases.

Norton RS, Pennington MW, Wulff H.

Curr Med Chem. 2004 Dec;11(23):3041-52. Review.

PMID:
15578998
7.

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.

Kalman K, Pennington MW, Lanigan MD, Nguyen A, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian EP, Cahalan MD, Norton RS, Chandy KG.

J Biol Chem. 1998 Dec 4;273(49):32697-707.

8.

A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes.

Beeton C, Wulff H, Singh S, Botsko S, Crossley G, Gutman GA, Cahalan MD, Pennington M, Chandy KG.

J Biol Chem. 2003 Mar 14;278(11):9928-37. Epub 2003 Jan 2.

9.

A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor.

Harvey AJ, Gable RW, Baell JB.

Bioorg Med Chem Lett. 2005 Jul 1;15(13):3193-6.

PMID:
15935664
10.

Anuroctoxin, a new scorpion toxin of the alpha-KTx 6 subfamily, is highly selective for Kv1.3 over IKCa1 ion channels of human T lymphocytes.

Bagdány M, Batista CV, Valdez-Cruz NA, Somodi S, Rodriguez de la Vega RC, Licea AF, Varga Z, Gáspár R, Possani LD, Panyi G.

Mol Pharmacol. 2005 Apr;67(4):1034-44. Epub 2004 Dec 22.

11.

N-Terminally extended analogues of the K⁺ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3.

Chang SC, Huq R, Chhabra S, Beeton C, Pennington MW, Smith BJ, Norton RS.

FEBS J. 2015 Jun;282(12):2247-59. doi: 10.1111/febs.13294. Epub 2015 Apr 23.

12.
13.

Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile.

Middleton RE, Sanchez M, Linde AR, Bugianesi RM, Dai G, Felix JP, Koprak SL, Staruch MJ, Bruguera M, Cox R, Ghosh A, Hwang J, Jones S, Kohler M, Slaughter RS, McManus OB, Kaczorowski GJ, Garcia ML.

Biochemistry. 2003 Nov 25;42(46):13698-707.

PMID:
14622016
14.

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases.

Beeton C, Pennington MW, Wulff H, Singh S, Nugent D, Crossley G, Khaytin I, Calabresi PA, Chen CY, Gutman GA, Chandy KG.

Mol Pharmacol. 2005 Apr;67(4):1369-81. Epub 2005 Jan 21.

15.

Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG.

J Biol Chem. 2000 Jan 14;275(2):1201-8.

16.

Identification of three separate binding sites on SHK toxin, a potent inhibitor of voltage-dependent potassium channels in human T-lymphocytes and rat brain.

Pennington MW, Mahnir VM, Krafte DS, Zaydenberg I, Byrnes ME, Khaytin I, Crowley K, Kem WR.

Biochem Biophys Res Commun. 1996 Feb 27;219(3):696-701.

PMID:
8645244
17.

Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.

Chang SC, Galea CA, Leung EW, Tajhya RB, Beeton C, Pennington MW, Norton RS.

Toxicon. 2012 Oct;60(5):840-50. doi: 10.1016/j.toxicon.2012.05.017. Epub 2012 May 31.

18.

Affinity and selectivity of ShK toxin for the Kv1 potassium channels from free energy simulations.

Rashid MH, Kuyucak S.

J Phys Chem B. 2012 Apr 26;116(16):4812-22. doi: 10.1021/jp300639x. Epub 2012 Apr 16.

PMID:
22480371
19.

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.

Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG.

FASEB J. 2014 Sep;28(9):3952-64. doi: 10.1096/fj.14-251967. Epub 2014 Jun 2.

20.

Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties.

Schmalhofer WA, Bao J, McManus OB, Green B, Matyskiela M, Wunderler D, Bugianesi RM, Felix JP, Hanner M, Linde-Arias AR, Ponte CG, Velasco L, Koo G, Staruch MJ, Miao S, Parsons WH, Rupprecht K, Slaughter RS, Kaczorowski GJ, Garcia ML.

Biochemistry. 2002 Jun 18;41(24):7781-94.

PMID:
12056910

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