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Items: 1 to 20 of 49

1.

Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers.

Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen LY, Carlezon WA Jr, Cohen BM, Béguin C.

Bioorg Med Chem. 2008 Feb 1;16(3):1279-86. Epub 2007 Oct 24.

2.

Synthesis and biological evaluation of 2-alkyl-2-methoxymethyl-salvinorin ethers as selective κ-opioid receptor agonists.

Lee DY, Deng G, Ma Z, Xu W, Yang L, Liu J, Dai R, Liu-Chen LY.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4689-92. doi: 10.1016/j.bmcl.2015.06.092. Epub 2015 Jul 3.

3.

Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18).

Béguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM.

Bioorg Med Chem Lett. 2006 Sep 1;16(17):4679-85. Epub 2006 Jun 13. Erratum in: Bioorg Med Chem Lett. 2008 Aug 1;18(15):4448.

PMID:
16777411
4.

Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues.

Lee DY, He M, Kondaveti L, Liu-Chen LY, Ma Z, Wang Y, Chen Y, Li JG, Beguin C, Carlezon WA Jr, Cohen B.

Bioorg Med Chem Lett. 2005 Oct 1;15(19):4169-73.

PMID:
16051487
5.

Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues.

Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA Jr, Cohen B.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5498-502. Epub 2006 Aug 30. Erratum in: Bioorg Med Chem Lett. 2008 Mar 15;18(6):2227.

PMID:
16945525
6.

Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues.

Lee DY, Karnati VV, He M, Liu-Chen LY, Kondaveti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA Jr, Cohen B.

Bioorg Med Chem Lett. 2005 Aug 15;15(16):3744-7.

PMID:
15993589
7.

Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist.

Munro TA, Rizzacasa MA, Roth BL, Toth BA, Yan F.

J Med Chem. 2005 Jan 27;48(2):345-8.

8.

Salvinorin A: a novel and highly selective kappa-opioid receptor agonist.

Yan F, Roth BL.

Life Sci. 2004 Oct 15;75(22):2615-9. Review.

PMID:
15369697
9.

Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor.

Sheffler DJ, Roth BL.

Trends Pharmacol Sci. 2003 Mar;24(3):107-9. Review.

PMID:
12628350
10.

Bioisosteric modification of salvinorin A, a potent and selective kappa-opioid receptor agonist.

Stewart DJ, Fahmy H, Roth BL, Yan F, Zjawiony JK.

Arzneimittelforschung. 2006;56(4):269-75.

PMID:
16724512
11.

Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring.

Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Dersch CM, Rothman RB, Prisinzano TE.

Bioorg Med Chem Lett. 2006 Jun 15;16(12):3170-4. Epub 2006 Apr 18.

PMID:
16621556
12.

Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor.

Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA Jr, Cohen BM.

Bioorg Med Chem. 2009 Feb 1;17(3):1370-80. doi: 10.1016/j.bmc.2008.12.012. Epub 2008 Dec 14.

13.

Herkinorin analogues with differential beta-arrestin-2 interactions.

Tidgewell K, Groer CE, Harding WW, Lozama A, Schmidt M, Marquam A, Hiemstra J, Partilla JS, Dersch CM, Rothman RB, Bohn LM, Prisinzano TE.

J Med Chem. 2008 Apr 24;51(8):2421-31. doi: 10.1021/jm701162g. Epub 2008 Apr 2.

14.

Semisynthesis and Kappa-Opioid Receptor Activity of Derivatives of Columbin, a Furanolactone Diterpene.

Yilmaz A, Crowley RS, Sherwood AM, Prisinzano TE.

J Nat Prod. 2017 Jul 28;80(7):2094-2100. doi: 10.1021/acs.jnatprod.7b00327. Epub 2017 Jul 18.

PMID:
28718638
15.
16.

Synthesis and antifungal activity of ethers, alcohols, and iodohydrin derivatives of sclareol against phytopathogenic fungi in vitro.

Ma M, Feng J, Li R, Chen SW, Xu H.

Bioorg Med Chem Lett. 2015 Jul 15;25(14):2773-7. doi: 10.1016/j.bmcl.2015.05.013. Epub 2015 May 14.

PMID:
26013848
17.

Convenient synthesis and in vitro pharmacological activity of 2-thioanalogs of salvinorins A and B.

Bikbulatov RV, Yan F, Roth BL, Zjawiony JK.

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2229-32. Epub 2007 Feb 2.

18.

Synthesis and opioid receptor affinity of a series of aralkyl ethers of 6 alpha- and 6 beta-naltrexol.

Nelson TD, Davis RD, Nelson WL.

J Med Chem. 1994 Dec 9;37(25):4270-7.

PMID:
7996538
19.

Asymmetric synthesis of salvinorin A, a potent kappa opioid receptor agonist.

Scheerer JR, Lawrence JF, Wang GC, Evans DA.

J Am Chem Soc. 2007 Jul 25;129(29):8968-9. Epub 2007 Jun 30. No abstract available.

PMID:
17602636
20.

Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2.

Takeuchi K, Holloway WG, Mitch CH, Quimby SJ, McKinzie JH, Suter TM, Statnick MA, Surface PL, Emmerson PJ, Thomas EM, Siegel MG.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6. Epub 2007 Oct 17.

PMID:
17980586

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