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Items: 1 to 20 of 104


An elaborate pathway required for Ras-mediated epigenetic silencing.

Gazin C, Wajapeyee N, Gobeil S, Virbasius CM, Green MR.

Nature. 2007 Oct 25;449(7165):1073-7.


Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.

Wajapeyee N, Malonia SK, Palakurthy RK, Green MR.

Genes Dev. 2013 Oct 15;27(20):2221-6. doi: 10.1101/gad.227413.113. Epub 2013 Oct 8.


RAS-mediated epigenetic inactivation of OPCML in oncogenic transformation of human ovarian surface epithelial cells.

Mei FC, Young TW, Liu J, Cheng X.

FASEB J. 2006 Mar;20(3):497-9. Epub 2005 Dec 29.


Silent assassin: oncogenic ras directs epigenetic inactivation of target genes.

Cheng X.

Sci Signal. 2008 Apr 1;1(13):pe14. doi: 10.1126/stke.113pe14.


Ras-mediated loss of the pro-apoptotic response protein Par-4 is mediated by DNA hypermethylation through Raf-independent and Raf-dependent signaling cascades in epithelial cells.

Pruitt K, Ulkü AS, Frantz K, Rojas RJ, Muniz-Medina VM, Rangnekar VM, Der CJ, Shields JM.

J Biol Chem. 2005 Jun 17;280(24):23363-70. Epub 2005 Apr 14.


Ras-induced epigenetic inactivation of the RRAD (Ras-related associated with diabetes) gene promotes glucose uptake in a human ovarian cancer model.

Wang Y, Li G, Mao F, Li X, Liu Q, Chen L, Lv L, Wang X, Wu J, Dai W, Wang G, Zhao E, Tang KF, Sun ZS.

J Biol Chem. 2014 May 16;289(20):14225-38. doi: 10.1074/jbc.M113.527671. Epub 2014 Mar 19.


Inhibition of Fas (CD95) expression and Fas-mediated apoptosis by oncogenic Ras.

Fenton RG, Hixon JA, Wright PW, Brooks AD, Sayers TJ.

Cancer Res. 1998 Aug 1;58(15):3391-400.


Thy-1 as a negative growth regulator in ras-transformed mouse fibroblasts.

Sugimoto Y, Ikawa Y, Nakauchi H.

Cancer Res. 1991 Jan 1;51(1):99-104.


Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.

Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa JP, Sidransky D, Baylin SB, Herman JG.

Cancer Res. 2000 May 1;60(9):2368-71.


Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells.

Thaler R, Spitzer S, Karlic H, Berger C, Klaushofer K, Varga F.

Biochem Pharmacol. 2013 Jan 15;85(2):173-85. doi: 10.1016/j.bcp.2012.10.016. Epub 2012 Oct 24.


Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells.

Ji W, Yang L, Yu L, Yuan J, Hu D, Zhang W, Yang J, Pang Y, Li W, Lu J, Fu J, Chen J, Lin Z, Chen W, Zhuang Z.

Carcinogenesis. 2008 Jun;29(6):1267-75. doi: 10.1093/carcin/bgn012. Epub 2008 Jan 19.


CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.

Irimia M, Fraga MF, Sanchez-Cespedes M, Esteller M.

Oncogene. 2004 Nov 11;23(53):8695-9.


DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis.

Foltz G, Yoon JG, Lee H, Ryken TC, Sibenaller Z, Ehrich M, Hood L, Madan A.

Oncogene. 2009 Jul 23;28(29):2667-77. doi: 10.1038/onc.2009.122. Epub 2009 May 25.


Resistance to oncogenic transformation in revertant R1 of human ras-transformed NIH 3T3 cells.

Kuzumaki N, Ogiso Y, Oda A, Fujita H, Suzuki H, Sato C, Müllauer L.

Mol Cell Biol. 1989 May;9(5):2258-63.


SCH 51344 inhibits ras transformation by a novel mechanism.

Kumar CC, Prorock-Rogers C, Kelly J, Dong Z, Lin JJ, Armstrong L, Kung HF, Weber MJ, Afonso A.

Cancer Res. 1995 Nov 1;55(21):5106-17.


Immortality, but not oncogenic transformation, of primary human cells leads to epigenetic reprogramming of DNA methylation and gene expression.

Gordon K, Clouaire T, Bao XX, Kemp SE, Xenophontos M, de Las Heras JI, Stancheva I.

Nucleic Acids Res. 2014 Apr;42(6):3529-41. doi: 10.1093/nar/gkt1351. Epub 2013 Dec 26.

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