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Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing.

Wang HW, Wang J, Ding F, Callahan K, Bratkowski MA, Butler JS, Nogales E, Ke A.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16844-9. Epub 2007 Oct 17.


Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family.

Lorentzen E, Basquin J, Tomecki R, Dziembowski A, Conti E.

Mol Cell. 2008 Mar 28;29(6):717-28. doi: 10.1016/j.molcel.2008.02.018.


Reconstitution, activities, and structure of the eukaryotic RNA exosome.

Liu Q, Greimann JC, Lima CD.

Cell. 2006 Dec 15;127(6):1223-37. Erratum in: Cell. 2007 Oct 5;131(1):188-9.


Exo- and endoribonucleolytic activities of yeast cytoplasmic and nuclear RNA exosomes are dependent on the noncatalytic core and central channel.

Wasmuth EV, Lima CD.

Mol Cell. 2012 Oct 12;48(1):133-44. doi: 10.1016/j.molcel.2012.07.012. Epub 2012 Aug 16.


Modulating the RNA processing and decay by the exosome: altering Rrp44/Dis3 activity and end-product.

Reis FP, Barbas A, Klauer-King AA, Tsanova B, Schaeffer D, López-Viñas E, Gómez-Puertas P, van Hoof A, Arraiano CM.

PLoS One. 2013 Nov 12;8(11):e76504. doi: 10.1371/journal.pone.0076504. eCollection 2013. Erratum in: PLoS One. 2015;10(8):e0136810.


The exosome subunit Rrp44 plays a direct role in RNA substrate recognition.

Schneider C, Anderson JT, Tollervey D.

Mol Cell. 2007 Jul 20;27(2):324-31.


The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation.

Bonneau F, Basquin J, Ebert J, Lorentzen E, Conti E.

Cell. 2009 Oct 30;139(3):547-59. doi: 10.1016/j.cell.2009.08.042.


Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA.

Wasmuth EV, Januszyk K, Lima CD.

Nature. 2014 Jul 24;511(7510):435-9. doi: 10.1038/nature13406. Epub 2014 Jul 6.


Activities of human RRP6 and structure of the human RRP6 catalytic domain.

Januszyk K, Liu Q, Lima CD.

RNA. 2011 Aug;17(8):1566-77. doi: 10.1261/rna.2763111. Epub 2011 Jun 24.


The N-terminal PIN domain of the exosome subunit Rrp44 harbors endonuclease activity and tethers Rrp44 to the yeast core exosome.

Schneider C, Leung E, Brown J, Tollervey D.

Nucleic Acids Res. 2009 Mar;37(4):1127-40. doi: 10.1093/nar/gkn1020. Epub 2009 Jan 7.


Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex.

Makino DL, Baumgärtner M, Conti E.

Nature. 2013 Mar 7;495(7439):70-5. doi: 10.1038/nature11870. Epub 2013 Feb 3.


Transcriptome-wide analysis of exosome targets.

Schneider C, Kudla G, Wlotzka W, Tuck A, Tollervey D.

Mol Cell. 2012 Nov 9;48(3):422-33. doi: 10.1016/j.molcel.2012.08.013. Epub 2012 Sep 20.


The eukaryotic RNA exosome.

Januszyk K, Lima CD.

Curr Opin Struct Biol. 2014 Feb;24:132-40. doi: 10.1016/ Epub 2014 Feb 11. Review.


RNA degradation paths in a 12-subunit nuclear exosome complex.

Makino DL, Schuch B, Stegmann E, Baumgärtner M, Basquin C, Conti E.

Nature. 2015 Aug 6;524(7563):54-8. doi: 10.1038/nature14865. Epub 2015 Jul 29.


Transcriptome-wide analysis of alternative routes for RNA substrates into the exosome complex.

Delan-Forino C, Schneider C, Tollervey D.

PLoS Genet. 2017 Mar 29;13(3):e1006699. doi: 10.1371/journal.pgen.1006699. eCollection 2017 Mar.


Rrp47 functions in RNA surveillance and stable RNA processing when divorced from the exoribonuclease and exosome-binding domains of Rrp6.

Garland W, Feigenbutz M, Turner M, Mitchell P.

RNA. 2013 Dec;19(12):1659-68. doi: 10.1261/rna.039388.113. Epub 2013 Oct 8.


Proteomic analysis of yeast mutant RNA exosome complexes.

Lourenço RF, Leme AF, Oliveira CC.

J Proteome Res. 2013 Dec 6;12(12):5912-22. doi: 10.1021/pr400972x. Epub 2013 Nov 26.


The Rrp6 C-terminal domain binds RNA and activates the nuclear RNA exosome.

Wasmuth EV, Lima CD.

Nucleic Acids Res. 2017 Jan 25;45(2):846-860. doi: 10.1093/nar/gkw1152. Epub 2016 Nov 29.


Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement.

Makino DL, Conti E.

Acta Crystallogr D Biol Crystallogr. 2013 Nov;69(Pt 11):2226-35. doi: 10.1107/S0907444913011438. Epub 2013 Oct 12.


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