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RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.

Tedeschi A, Ciciarello M, Mangiacasale R, Roscioli E, Rensen WM, Lavia P.

J Cell Sci. 2007 Nov 1;120(Pt 21):3748-61. Epub 2007 Oct 16.


Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells.

Ciciarello M, Mangiacasale R, Thibier C, Guarguaglini G, Marchetti E, Di Fiore B, Lavia P.

J Cell Sci. 2004 Dec 15;117(Pt 26):6511-22. Epub 2004 Nov 30.


Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate.

Yokoyama H, Gruss OJ, Rybina S, Caudron M, Schelder M, Wilm M, Mattaj IW, Karsenti E.

J Cell Biol. 2008 Mar 10;180(5):867-75. doi: 10.1083/jcb.200706189. Epub 2008 Mar 3.


The mechanism of spindle assembly: functions of Ran and its target TPX2.

Gruss OJ, Vernos I.

J Cell Biol. 2004 Sep 27;166(7):949-55. Review.


ISWI is a RanGTP-dependent MAP required for chromosome segregation.

Yokoyama H, Rybina S, Santarella-Mellwig R, Mattaj IW, Karsenti E.

J Cell Biol. 2009 Dec 14;187(6):813-29. doi: 10.1083/jcb.200906020.


Ran induces spindle assembly by reversing the inhibitory effect of importin alpha on TPX2 activity.

Gruss OJ, Carazo-Salas RE, Schatz CA, Guarguaglini G, Kast J, Wilm M, Le Bot N, Vernos I, Karsenti E, Mattaj IW.

Cell. 2001 Jan 12;104(1):83-93.


The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles.

Ma N, Matsunaga S, Morimoto A, Sakashita G, Urano T, Uchiyama S, Fukui K.

J Cell Sci. 2011 Feb 1;124(Pt 3):394-404. doi: 10.1242/jcs.063347.


Ran-GTP stabilises microtubule asters and inhibits nuclear assembly in Xenopus egg extracts.

Zhang C, Hughes M, Clarke PR.

J Cell Sci. 1999 Jul;112 ( Pt 14):2453-61.


The ran GTPase regulates mitotic spindle assembly.

Kalab P, Pu RT, Dasso M.

Curr Biol. 1999 May 6;9(9):481-4.


Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.

Bird AW, Hyman AA.

J Cell Biol. 2008 Jul 28;182(2):289-300. doi: 10.1083/jcb.200802005.


Phosphorylation of Ran-binding protein-1 by Polo-like kinase-1 is required for interaction with Ran and early mitotic progression.

Hwang HI, Ji JH, Jang YJ.

J Biol Chem. 2011 Sep 23;286(38):33012-20. doi: 10.1074/jbc.M111.255620. Epub 2011 Aug 3.


Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo.

Guarguaglini G, Renzi L, D'Ottavio F, Di Fiore B, Casenghi M, Cundari E, Lavia P.

Cell Growth Differ. 2000 Aug;11(8):455-65.


Downregulation of protein 4.1R, a mature centriole protein, disrupts centrosomes, alters cell cycle progression, and perturbs mitotic spindles and anaphase.

Krauss SW, Spence JR, Bahmanyar S, Barth AI, Go MM, Czerwinski D, Meyer AJ.

Mol Cell Biol. 2008 Apr;28(7):2283-94. doi: 10.1128/MCB.02021-07. Epub 2008 Jan 22.


Cdc2/cyclin B1 regulates centrosomal Nlp proteolysis and subcellular localization.

Zhao X, Jin S, Song Y, Zhan Q.

Cancer Biol Ther. 2010 Nov 1;10(9):945-52. doi: 10.4161/cbt.10.9.13368. Epub 2010 Nov 1.


Importin beta is a mitotic target of the small GTPase Ran in spindle assembly.

Nachury MV, Maresca TJ, Salmon WC, Waterman-Storer CM, Heald R, Weis K.

Cell. 2001 Jan 12;104(1):95-106.


HURP is part of a Ran-dependent complex involved in spindle formation.

Koffa MD, Casanova CM, Santarella R, Köcher T, Wilm M, Mattaj IW.

Curr Biol. 2006 Apr 18;16(8):743-54.


Hepatoma up-regulated protein is required for chromatin-induced microtubule assembly independently of TPX2.

Casanova CM, Rybina S, Yokoyama H, Karsenti E, Mattaj IW.

Mol Biol Cell. 2008 Nov;19(11):4900-8. doi: 10.1091/mbc.E08-06-0624. Epub 2008 Sep 17.


Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis.

Hong KU, Kim HJ, Kim HS, Seong YS, Hong KM, Bae CD, Park J.

J Biol Chem. 2009 Jun 12;284(24):16501-12. doi: 10.1074/jbc.M900257200. Epub 2009 Apr 15.


RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner.

Rensen WM, Roscioli E, Tedeschi A, Mangiacasale R, Ciciarello M, Di Gioia SA, Lavia P.

Oncogene. 2009 Apr 16;28(15):1748-58. doi: 10.1038/onc.2009.24. Epub 2009 Mar 9.


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