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Items: 1 to 20 of 310

1.

Identification of stem cells in small intestine and colon by marker gene Lgr5.

Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H.

Nature. 2007 Oct 25;449(7165):1003-7. Epub 2007 Oct 14.

PMID:
17934449
2.

Very long-term self-renewal of small intestine, colon, and hair follicles from cycling Lgr5+ve stem cells.

Barker N, van Es JH, Jaks V, Kasper M, Snippert H, Toftgård R, Clevers H.

Cold Spring Harb Symp Quant Biol. 2008;73:351-6. doi: 10.1101/sqb.2008.72.003.

PMID:
19478326
3.

LGR5 deficiency deregulates Wnt signaling and leads to precocious Paneth cell differentiation in the fetal intestine.

Garcia MI, Ghiani M, Lefort A, Libert F, Strollo S, Vassart G.

Dev Biol. 2009 Jul 1;331(1):58-67. doi: 10.1016/j.ydbio.2009.04.020. Epub 2009 Apr 24.

4.

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H.

Cell. 2010 Oct 1;143(1):134-44. doi: 10.1016/j.cell.2010.09.016.

5.

Wnt signaling, lgr5, and stem cells in the intestine and skin.

Haegebarth A, Clevers H.

Am J Pathol. 2009 Mar;174(3):715-21. doi: 10.2353/ajpath.2009.080758. Epub 2009 Feb 5. Review.

6.

Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer.

Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, Hasegawa H, Kitajima M, Kitagawa Y, Sakamoto M.

Cancer Sci. 2010 Jul;101(7):1731-7. doi: 10.1111/j.1349-7006.2010.01571.x. Epub 2010 Mar 24. Erratum in: Cancer Sci. 2010 Jul;101(7):1767.

7.

Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.

Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, López-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29.

8.

Transcription factor achaete scute-like 2 controls intestinal stem cell fate.

van der Flier LG, van Gijn ME, Hatzis P, Kujala P, Haegebarth A, Stange DE, Begthel H, van den Born M, Guryev V, Oving I, van Es JH, Barker N, Peters PJ, van de Wetering M, Clevers H.

Cell. 2009 Mar 6;136(5):903-12. doi: 10.1016/j.cell.2009.01.031.

9.

Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H.

Science. 2012 Aug 10;337(6095):730-5. doi: 10.1126/science.1224676. Epub 2012 Aug 1.

10.

Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.

Barker N, Clevers H.

Gastroenterology. 2010 May;138(5):1681-96. doi: 10.1053/j.gastro.2010.03.002. Review.

PMID:
20417836
11.

Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic mice.

Garabedian EM, Roberts LJ, McNevin MS, Gordon JI.

J Biol Chem. 1997 Sep 19;272(38):23729-40.

12.

Lgr5 marks cycling, yet long-lived, hair follicle stem cells.

Jaks V, Barker N, Kasper M, van Es JH, Snippert HJ, Clevers H, Toftgård R.

Nat Genet. 2008 Nov;40(11):1291-9. doi: 10.1038/ng.239. Epub 2008 Oct 12.

PMID:
18849992
13.

Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin.

Snippert HJ, Haegebarth A, Kasper M, Jaks V, van Es JH, Barker N, van de Wetering M, van den Born M, Begthel H, Vries RG, Stange DE, Toftgård R, Clevers H.

Science. 2010 Mar 12;327(5971):1385-9. doi: 10.1126/science.1184733.

14.

Lgr5 positive stem cells sorted from small intestines of diabetic mice differentiate into higher proportion of absorptive cells and Paneth cells in vitro.

Zhong XY, Yu T, Zhong W, Li JY, Xia ZS, Yuan YH, Yu Z, Chen QK.

Dev Growth Differ. 2015 Aug;57(6):453-65. doi: 10.1111/dgd.12226. Epub 2015 Jun 30.

PMID:
26122164
15.

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.

Schuijers J, van der Flier LG, van Es J, Clevers H.

Stem Cell Reports. 2014 Aug 12;3(2):234-41. doi: 10.1016/j.stemcr.2014.05.018. Epub 2014 Jun 26.

16.

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.

Tian H, Biehs B, Warming S, Leong KG, Rangell L, Klein OD, de Sauvage FJ.

Nature. 2011 Sep 18;478(7368):255-9. doi: 10.1038/nature10408. Erratum in: Nature. 2012 Feb 2;482(7383):120.

17.

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation.

Zhu L, Gibson P, Currle DS, Tong Y, Richardson RJ, Bayazitov IT, Poppleton H, Zakharenko S, Ellison DW, Gilbertson RJ.

Nature. 2009 Jan 29;457(7229):603-7. doi: 10.1038/nature07589. Epub 2008 Dec 17.

18.

Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice.

Rothenberg ME, Nusse Y, Kalisky T, Lee JJ, Dalerba P, Scheeren F, Lobo N, Kulkarni S, Sim S, Qian D, Beachy PA, Pasricha PJ, Quake SR, Clarke MF.

Gastroenterology. 2012 May;142(5):1195-1205.e6. doi: 10.1053/j.gastro.2012.02.006. Epub 2012 Feb 11.

19.

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.

Kim TH, Escudero S, Shivdasani RA.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3932-7. doi: 10.1073/pnas.1113890109. Epub 2012 Feb 21.

20.

EP receptor expression in human intestinal epithelium and localization relative to the stem cell zone of the crypts.

Olsen Hult LT, Kleiveland CR, Fosnes K, Jacobsen M, Lea T.

PLoS One. 2011;6(10):e26816. doi: 10.1371/journal.pone.0026816. Epub 2011 Oct 25.

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