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Items: 1 to 20 of 129

1.

A single mutation in the PB1-F2 of H5N1 (HK/97) and 1918 influenza A viruses contributes to increased virulence.

Conenello GM, Zamarin D, Perrone LA, Tumpey T, Palese P.

PLoS Pathog. 2007 Oct 5;3(10):1414-21.

2.

A single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo.

Conenello GM, Tisoncik JR, Rosenzweig E, Varga ZT, Palese P, Katze MG.

J Virol. 2011 Jan;85(2):652-62. doi: 10.1128/JVI.01987-10. Epub 2010 Nov 17.

3.

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species.

Schmolke M, Manicassamy B, Pena L, Sutton T, Hai R, Varga ZT, Hale BG, Steel J, Pérez DR, García-Sastre A.

PLoS Pathog. 2011 Aug;7(8):e1002186. doi: 10.1371/journal.ppat.1002186. Epub 2011 Aug 11.

4.

PB1-F2 attenuates virulence of highly pathogenic avian H5N1 influenza virus in chickens.

Leymarie O, Embury-Hyatt C, Chevalier C, Jouneau L, Moroldo M, Da Costa B, Berhane Y, Delmas B, Weingartl HM, Le Goffic R.

PLoS One. 2014 Jun 24;9(6):e100679. doi: 10.1371/journal.pone.0100679. eCollection 2014.

5.

Strain-dependent effects of PB1-F2 of triple-reassortant H3N2 influenza viruses in swine.

Pena L, Vincent AL, Loving CL, Henningson JN, Lager KM, Li W, Perez DR.

J Gen Virol. 2012 Oct;93(Pt 10):2204-14. doi: 10.1099/vir.0.045005-0. Epub 2012 Jul 18.

6.

Influenza A virus PB1-F2 protein contributes to viral pathogenesis in mice.

Zamarin D, Ortigoza MB, Palese P.

J Virol. 2006 Aug;80(16):7976-83.

7.

PB1-F2 expression by the 2009 pandemic H1N1 influenza virus has minimal impact on virulence in animal models.

Hai R, Schmolke M, Varga ZT, Manicassamy B, Wang TT, Belser JA, Pearce MB, García-Sastre A, Tumpey TM, Palese P.

J Virol. 2010 May;84(9):4442-50. doi: 10.1128/JVI.02717-09. Epub 2010 Feb 24.

8.

Glycine at Position 622 in PB1 Contributes to the Virulence of H5N1 Avian Influenza Virus in Mice.

Feng X, Wang Z, Shi J, Deng G, Kong H, Tao S, Li C, Liu L, Guan Y, Chen H.

J Virol. 2015 Dec 9;90(4):1872-9. doi: 10.1128/JVI.02387-15.

9.

Differential localization and function of PB1-F2 derived from different strains of influenza A virus.

Chen CJ, Chen GW, Wang CH, Huang CH, Wang YC, Shih SR.

J Virol. 2010 Oct;84(19):10051-62. doi: 10.1128/JVI.00592-10. Epub 2010 Jul 21.

10.

Kinetic characterization of PB1-F2-mediated immunopathology during highly pathogenic avian H5N1 influenza virus infection.

Leymarie O, Jouvion G, Hervé PL, Chevalier C, Lorin V, Lecardonnel J, Da Costa B, Delmas B, Escriou N, Le Goffic R.

PLoS One. 2013;8(3):e57894. doi: 10.1371/journal.pone.0057894. Epub 2013 Mar 1.

11.

Emergence of Highly Pathogenic Avian Influenza A(H5N1) Virus PB1-F2 Variants and Their Virulence in BALB/c Mice.

Kamal RP, Kumar A, Davis CT, Tzeng WP, Nguyen T, Donis RO, Katz JM, York IA.

J Virol. 2015 Jun;89(11):5835-46. doi: 10.1128/JVI.03137-14. Epub 2015 Mar 18.

12.

The influenza A virus protein PB1-F2: killing two birds with one stone?

Varga ZT, Palese P.

Virulence. 2011 Nov-Dec;2(6):542-6. doi: 10.4161/viru.2.6.17812. Epub 2011 Nov 1.

13.

Restored PB1-F2 in the 2009 pandemic H1N1 influenza virus has minimal effects in swine.

Pena L, Vincent AL, Loving CL, Henningson JN, Lager KM, Lorusso A, Perez DR.

J Virol. 2012 May;86(10):5523-32. doi: 10.1128/JVI.00134-12. Epub 2012 Feb 29.

14.

PB1-F2 Protein Does Not Impact the Virulence of Triple-Reassortant H3N2 Swine Influenza Virus in Pigs but Alters Pathogenicity and Transmission in Turkeys.

Deventhiran J, Kumar SR, Raghunath S, Leroith T, Elankumaran S.

J Virol. 2015 Oct 14;90(1):222-31. doi: 10.1128/JVI.01551-15.

15.

Immunopathogenic and antibacterial effects of H3N2 influenza A virus PB1-F2 map to amino acid residues 62, 75, 79, and 82.

Alymova IV, Green AM, van de Velde N, McAuley JL, Boyd KL, Ghoneim HE, McCullers JA.

J Virol. 2011 Dec;85(23):12324-33. doi: 10.1128/JVI.05872-11. Epub 2011 Sep 21.

16.

Molecular signatures of virulence in the PB1-F2 proteins of H5N1 influenza viruses.

Smith AM, McCullers JA.

Virus Res. 2013 Dec 5;178(1):146-50. doi: 10.1016/j.virusres.2013.02.012. Epub 2013 Mar 14.

17.

Three amino acid changes in PB1-F2 of highly pathogenic H5N1 avian influenza virus affect pathogenicity in mallard ducks.

Marjuki H, Scholtissek C, Franks J, Negovetich NJ, Aldridge JR, Salomon R, Finkelstein D, Webster RG.

Arch Virol. 2010 Jun;155(6):925-34. doi: 10.1007/s00705-010-0666-4. Epub 2010 Apr 11.

18.

PB1-mediated virulence attenuation of H5N1 influenza virus in mice is associated with PB2.

Li J, Li Y, Hu Y, Chang G, Sun W, Yang Y, Kang X, Wu X, Zhu Q.

J Gen Virol. 2011 Jun;92(Pt 6):1435-44. doi: 10.1099/vir.0.030718-0. Epub 2011 Mar 2.

PMID:
21367983
19.

Effects of PB1-F2 on the pathogenicity of H1N1 swine influenza virus in mice and pigs.

Lee J, Henningson J, Ma J, Duff M, Lang Y, Li Y, Li Y, Nagy A, Sunwoo S, Bawa B, Yang J, Bai D, Richt JA, Ma W.

J Gen Virol. 2016 Dec 23. doi: 10.1099/jgv.0.000695. [Epub ahead of print]

PMID:
28008819
20.

Influenza A virus PB1-F2 protein expression is regulated in a strain-specific manner by sequences located downstream of the PB1-F2 initiation codon.

Buehler J, Navi D, Lorusso A, Vincent A, Lager K, Miller CL.

J Virol. 2013 Oct;87(19):10687-99. doi: 10.1128/JVI.01520-13. Epub 2013 Jul 24.

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