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Items: 1 to 20 of 168


Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9.

Ramocki NM, Wilkins HR, Magness ST, Simmons JG, Scull BP, Lee GH, McNaughton KK, Lund PK.

Endocrinology. 2008 Jan;149(1):261-7. Epub 2007 Oct 4.


Glucagon-like peptide-2 activates beta-catenin signaling in the mouse intestinal crypt: role of insulin-like growth factor-I.

Dubé PE, Rowland KJ, Brubaker PL.

Endocrinology. 2008 Jan;149(1):291-301. Epub 2007 Sep 20.


Deletion of the WNT target and cancer stem cell marker CD44 in Apc(Min/+) mice attenuates intestinal tumorigenesis.

Zeilstra J, Joosten SP, Dokter M, Verwiel E, Spaargaren M, Pals ST.

Cancer Res. 2008 May 15;68(10):3655-61. doi: 10.1158/0008-5472.CAN-07-2940.


BCL9-2 promotes early stages of intestinal tumor progression.

Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W.

Gastroenterology. 2011 Oct;141(4):1359-70, 1370.e1-3. doi: 10.1053/j.gastro.2011.06.039. Epub 2011 Jun 23.


Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth.

Simmons JG, Ling Y, Wilkins H, Fuller CR, D'Ercole AJ, Fagin J, Lund PK.

Am J Physiol Gastrointest Liver Physiol. 2007 Nov;293(5):G995-1003. Epub 2007 Sep 6.


MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms.

Joosten SPJ, Zeilstra J, van Andel H, Mijnals RC, Zaunbrecher J, Duivenvoorden AAM, van de Wetering M, Clevers H, Spaargaren M, Pals ST.

Gastroenterology. 2017 Oct;153(4):1040-1053.e4. doi: 10.1053/j.gastro.2017.07.008. Epub 2017 Jul 14.


SOX9 directly regulates IGFBP-4 in the intestinal epithelium.

Shi Z, Chiang CI, Mistretta TA, Major A, Mori-Akiyama Y.

Am J Physiol Gastrointest Liver Physiol. 2013 Jul 1;305(1):G74-83. doi: 10.1152/ajpgi.00086.2013. Epub 2013 May 9.


Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway.

Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, Clevers H, Pals ST.

Am J Pathol. 1999 Feb;154(2):515-23.


Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention.

Fischer JM, Schepers AG, Clevers H, Shibata D, Liskay RM.

Carcinogenesis. 2014 Jan;35(1):237-46. doi: 10.1093/carcin/bgt296. Epub 2013 Aug 29.


Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation.

Feng Y, Sentani K, Wiese A, Sands E, Green M, Bommer GT, Cho KR, Fearon ER.

Am J Pathol. 2013 Aug;183(2):493-503. doi: 10.1016/j.ajpath.2013.04.013. Epub 2013 Jun 13.


Transcriptional corepressor MTG16 regulates small intestinal crypt proliferation and crypt regeneration after radiation-induced injury.

Poindexter SV, Reddy VK, Mittal MK, Williams AM, Washington MK, Harris E, Mah A, Hiebert SW, Singh K, Chaturvedi R, Wilson KT, Lund PK, Williams CS.

Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G562-71. doi: 10.1152/ajpgi.00253.2014. Epub 2015 Jan 8.


SOX9 is required for the differentiation of paneth cells in the intestinal epithelium.

Mori-Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B.

Gastroenterology. 2007 Aug;133(2):539-46. Epub 2007 May 21.


Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epithelium.

Bastide P, Darido C, Pannequin J, Kist R, Robine S, Marty-Double C, Bibeau F, Scherer G, Joubert D, Hollande F, Blache P, Jay P.

J Cell Biol. 2007 Aug 13;178(4):635-48.


Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells.

Moorefield EC, Andres SF, Blue RE, Van Landeghem L, Mah AT, Santoro MA, Ding S.

Aging (Albany NY). 2017 Aug 29;9(8):1898-1915. doi: 10.18632/aging.101279.


Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors.

Pannequin J, Delaunay N, Buchert M, Surrel F, Bourgaux JF, Ryan J, Boireau S, Coelho J, Pélegrin A, Singh P, Shulkes A, Yim M, Baldwin GS, Pignodel C, Lambeau G, Jay P, Joubert D, Hollande F.

Gastroenterology. 2007 Nov;133(5):1554-68. Epub 2007 Oct 24.


Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.

McConnell BB, Bialkowska AB, Nandan MO, Ghaleb AM, Gordon FJ, Yang VW.

Cancer Res. 2009 May 15;69(10):4125-33. doi: 10.1158/0008-5472.CAN-08-4402. Epub 2009 May 12.


SOX9 maintains reserve stem cells and preserves radioresistance in mouse small intestine.

Roche KC, Gracz AD, Liu XF, Newton V, Akiyama H, Magness ST.

Gastroenterology. 2015 Nov;149(6):1553-1563.e10. doi: 10.1053/j.gastro.2015.07.004. Epub 2015 Jul 11.


Foxf2 in intestinal fibroblasts reduces numbers of Lgr5(+) stem cells and adenoma formation by inhibiting Wnt signaling.

Nik AM, Reyahi A, Pontén F, Carlsson P.

Gastroenterology. 2013 May;144(5):1001-11. doi: 10.1053/j.gastro.2013.01.045. Epub 2013 Jan 31.


The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine.

Lin S, Lee SJ, Shim H, Chun J, Yun CC.

Am J Physiol Gastrointest Liver Physiol. 2010 Nov;299(5):G1128-38. doi: 10.1152/ajpgi.00321.2010. Epub 2010 Aug 19.

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