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Items: 1 to 20 of 99

1.

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain.

Wiesner S, Ogunjimi AA, Wang HR, Rotin D, Sicheri F, Wrana JL, Forman-Kay JD.

Cell. 2007 Aug 24;130(4):651-62.

2.

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain.

Ogunjimi AA, Briant DJ, Pece-Barbara N, Le Roy C, Di Guglielmo GM, Kavsak P, Rasmussen RK, Seet BT, Sicheri F, Wrana JL.

Mol Cell. 2005 Aug 5;19(3):297-308.

3.

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation.

Kavsak P, Rasmussen RK, Causing CG, Bonni S, Zhu H, Thomsen GH, Wrana JL.

Mol Cell. 2000 Dec;6(6):1365-75.

4.

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.

Chong PA, Lin H, Wrana JL, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18404-9. doi: 10.1073/pnas.1003023107.

5.

Structural and functional framework for the autoinhibition of Nedd4-family ubiquitin ligases.

Mari S, Ruetalo N, Maspero E, Stoffregen MC, Pasqualato S, Polo S, Wiesner S.

Structure. 2014 Nov 4;22(11):1639-49. doi: 10.1016/j.str.2014.09.006.

6.

An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.

Chong PA, Lin H, Wrana JL, Forman-Kay JD.

J Biol Chem. 2006 Jun 23;281(25):17069-75.

7.

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases.

Morén A, Imamura T, Miyazono K, Heldin CH, Moustakas A.

J Biol Chem. 2005 Jun 10;280(23):22115-23.

9.

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1.

Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F.

Nat Cell Biol. 2008 Aug;10(8):994-1002. doi: 10.1038/ncb1760. Erratum in: Nat Cell Biol. 2010 Jun;12(6):625.

PMID:
18641638
10.
11.

A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.

Pandya RK, Partridge JR, Love KR, Schwartz TU, Ploegh HL.

J Biol Chem. 2010 Feb 19;285(8):5664-73. doi: 10.1074/jbc.M109.051805.

12.

Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase.

Spratt DE, Mercier P, Shaw GS.

PLoS One. 2013 Aug 15;8(8):e74047. doi: 10.1371/journal.pone.0074047.

13.

WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation.

Magnifico A, Ettenberg S, Yang C, Mariano J, Tiwari S, Fang S, Lipkowitz S, Weissman AM.

J Biol Chem. 2003 Oct 31;278(44):43169-77.

14.

Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation.

Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F.

J Biol Chem. 2013 Feb 1;288(5):2976-85. doi: 10.1074/jbc.M112.430066.

15.

Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.

Kamadurai HB, Souphron J, Scott DC, Duda DM, Miller DJ, Stringer D, Piper RC, Schulman BA.

Mol Cell. 2009 Dec 25;36(6):1095-102. doi: 10.1016/j.molcel.2009.11.010.

16.

Control of the dynamics and homeostasis of the Drosophila Hedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases.

Brigui A, Hofmann L, Argüelles C, Sanial M, Holmgren RA, Plessis A.

Open Biol. 2015 Oct;5(10). pii: 150112. doi: 10.1098/rsob.150112.

17.

Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection.

Lu K, Li P, Zhang M, Xing G, Li X, Zhou W, Bartlam M, Zhang L, Rao Z, He F.

J Biol Chem. 2011 May 13;286(19):16861-70. doi: 10.1074/jbc.M110.211979.

18.

An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein.

Li H, Seth A.

Oncogene. 2004 Mar 11;23(10):1801-8.

PMID:
14755250
19.

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3.

Kamadurai HB, Qiu Y, Deng A, Harrison JS, Macdonald C, Actis M, Rodrigues P, Miller DJ, Souphron J, Lewis SM, Kurinov I, Fujii N, Hammel M, Piper R, Kuhlman B, Schulman BA.

Elife. 2013 Aug 8;2:e00828. doi: 10.7554/eLife.00828.

20.

Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.

Suzuki C, Murakami G, Fukuchi M, Shimanuki T, Shikauchi Y, Imamura T, Miyazono K.

J Biol Chem. 2002 Oct 18;277(42):39919-25.

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