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Items: 1 to 20 of 73

1.

Stability of checkpoint kinase 2 is regulated via phosphorylation at serine 456.

Kass EM, Ahn J, Tanaka T, Freed-Pastor WA, Keezer S, Prives C.

J Biol Chem. 2007 Oct 12;282(41):30311-21. Epub 2007 Aug 21.

2.

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.

Wu X, Chen J.

J Biol Chem. 2003 Sep 19;278(38):36163-8. Epub 2003 Jul 9.

3.

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

Bahassi el M, Myer DL, McKenney RJ, Hennigan RF, Stambrook PJ.

Mutat Res. 2006 Apr 11;596(1-2):166-76. Epub 2006 Feb 14.

PMID:
16481012
4.

Exploring the intramolecular phosphorylation sites in human Chk2.

Olsen BB, Larsen MR, Boldyreff B, Niefind K, Issinger OG.

Mutat Res. 2008 Nov 10;646(1-2):50-9. doi: 10.1016/j.mrfmmm.2008.09.002. Epub 2008 Sep 11.

PMID:
18812180
5.

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.

Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ.

Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10389-94.

6.

Autophosphorylated residues involved in the regulation of human chk2 in vitro.

Gabant G, Lorphelin A, Nozerand N, Marchetti C, Bellanger L, Dedieu A, Quéméneur E, Alpha-Bazin B.

J Mol Biol. 2008 Jul 11;380(3):489-503. doi: 10.1016/j.jmb.2008.04.053. Epub 2008 May 1.

PMID:
18538787
7.

Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks.

Ward IM, Wu X, Chen J.

J Biol Chem. 2001 Dec 21;276(51):47755-8. Epub 2001 Oct 19.

8.

Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.

Gibson SL, Bindra RS, Glazer PM.

Cancer Res. 2005 Dec 1;65(23):10734-41.

9.

MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways.

Lou Z, Minter-Dykhouse K, Wu X, Chen J.

Nature. 2003 Feb 27;421(6926):957-61.

PMID:
12607004
10.

The Chk2 protein kinase.

Ahn J, Urist M, Prives C.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1039-47. Review.

PMID:
15279791
12.

Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity.

Zhou BB, Chaturvedi P, Spring K, Scott SP, Johanson RA, Mishra R, Mattern MR, Winkler JD, Khanna KK.

J Biol Chem. 2000 Apr 7;275(14):10342-8.

15.

Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase.

Cai Z, Chehab NH, Pavletich NP.

Mol Cell. 2009 Sep 24;35(6):818-29. doi: 10.1016/j.molcel.2009.09.007.

16.

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.

Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shieh SY, Shen CY.

EMBO J. 2008 Dec 3;27(23):3140-50. doi: 10.1038/emboj.2008.229. Epub 2008 Oct 30.

17.

Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.

Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13102-7. Epub 2001 Oct 30.

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20.

Casein Kinase II phosphorylation-induced conformational switch triggers degradation of the papillomavirus E2 protein.

Penrose KJ, Garcia-Alai M, de Prat-Gay G, McBride AA.

J Biol Chem. 2004 May 21;279(21):22430-9. Epub 2004 Mar 9.

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