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Items: 1 to 20 of 164

1.

Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling.

Shembade N, Harhaj NS, Liebl DJ, Harhaj EW.

EMBO J. 2007 Sep 5;26(17):3910-22. Epub 2007 Aug 16.

2.

The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling.

Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW.

EMBO J. 2009 Mar 4;28(5):513-22. doi: 10.1038/emboj.2008.285. Epub 2009 Jan 8.

3.

TRAF6 negatively regulates TNFalpha-induced NF-kappaB activation.

Funakoshi-Tago M, Kamada N, Shimizu T, Hashiguchi Y, Tago K, Sonoda Y, Kasahara T.

Cytokine. 2009 Feb;45(2):72-9. doi: 10.1016/j.cyto.2008.10.010. Epub 2008 Dec 16.

PMID:
19091594
4.

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.

Shembade N, Ma A, Harhaj EW.

Science. 2010 Feb 26;327(5969):1135-9. doi: 10.1126/science.1182364.

5.

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis.

Kobayashi N, Kadono Y, Naito A, Matsumoto K, Yamamoto T, Tanaka S, Inoue J.

EMBO J. 2001 Mar 15;20(6):1271-80.

6.

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation.

Iha H, Peloponese JM, Verstrepen L, Zapart G, Ikeda F, Smith CD, Starost MF, Yedavalli V, Heyninck K, Dikic I, Beyaert R, Jeang KT.

EMBO J. 2008 Feb 20;27(4):629-41. doi: 10.1038/emboj.2008.5. Epub 2008 Jan 31.

7.
8.

The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1.

Shembade N, Pujari R, Harhaj NS, Abbott DW, Harhaj EW.

Nat Immunol. 2011 Jul 17;12(9):834-43. doi: 10.1038/ni.2066.

9.

Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases.

Brechter AB, Persson E, Lundgren I, Lerner UH.

Bone. 2008 Jul;43(1):72-83. doi: 10.1016/j.bone.2008.02.003. Epub 2008 Mar 10.

PMID:
18467203
10.

Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination.

Chen H, Wu Y, Zhang Y, Jin L, Luo L, Xue B, Lu C, Zhang X, Yin Z.

FEBS Lett. 2006 May 29;580(13):3145-52. Epub 2006 May 2.

11.

Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.

Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, Mantovani A, Rothe M, Muzio M, Arditi M.

J Biol Chem. 1999 Mar 19;274(12):7611-4.

12.

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.

Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB.

Oncogene. 2007 Feb 22;26(8):1201-12. Epub 2006 Aug 21.

PMID:
16924232
13.

Tanshinone IIA inhibits LPS-induced NF-kappaB activation in RAW 264.7 cells: possible involvement of the NIK-IKK, ERK1/2, p38 and JNK pathways.

Jang SI, Kim HJ, Kim YJ, Jeong SI, You YO.

Eur J Pharmacol. 2006 Aug 7;542(1-3):1-7. Epub 2006 May 6.

PMID:
16797002
15.

Syntenin negatively regulates TRAF6-mediated IL-1R/TLR4 signaling.

Chen F, Du Y, Zhang Z, Chen G, Zhang M, Shu HB, Zhai Z, Chen D.

Cell Signal. 2008 Apr;20(4):666-74. doi: 10.1016/j.cellsig.2007.12.002. Epub 2007 Dec 8.

PMID:
18234474
16.

Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts.

Eda H, Shimada H, Beidler DR, Monahan JB.

Rheumatol Int. 2011 Nov;31(11):1525-30. doi: 10.1007/s00296-010-1688-7. Epub 2010 Dec 23.

PMID:
21181166
18.
19.

Sesquiterpene lactone parthenolide blocks lipopolysaccharide-induced osteolysis through the suppression of NF-kappaB activity.

Yip KH, Zheng MH, Feng HT, Steer JH, Joyce DA, Xu J.

J Bone Miner Res. 2004 Nov;19(11):1905-16. Epub 2004 Sep 27.

20.

Bacterial lipopolysaccharide directly induces angiogenesis through TRAF6-mediated activation of NF-kappaB and c-Jun N-terminal kinase.

Pollet I, Opina CJ, Zimmerman C, Leong KG, Wong F, Karsan A.

Blood. 2003 Sep 1;102(5):1740-2. Epub 2003 Apr 24.

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