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CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin.

Singleton PA, Salgia R, Moreno-Vinasco L, Moitra J, Sammani S, Mirzapoiazova T, Garcia JG.

J Biol Chem. 2007 Oct 19;282(42):30643-57. Epub 2007 Aug 16.


Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin.

Jacobson JR, Dudek SM, Singleton PA, Kolosova IA, Verin AD, Garcia JG.

Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L289-95.


Akt-mediated transactivation of the S1P1 receptor in caveolin-enriched microdomains regulates endothelial barrier enhancement by oxidized phospholipids.

Singleton PA, Chatchavalvanich S, Fu P, Xing J, Birukova AA, Fortune JA, Klibanov AM, Garcia JG, Birukov KG.

Circ Res. 2009 Apr 24;104(8):978-86. doi: 10.1161/CIRCRESAHA.108.193367. Epub 2009 Mar 12.


Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines.

Watanabe T, Tsuda M, Makino Y, Ichihara S, Sawa H, Minami A, Mochizuki N, Nagashima K, Tanaka S.

Mol Cancer Res. 2006 Jul;4(7):499-510.


CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration.

Bourguignon LY, Zhu H, Shao L, Chen YW.

J Biol Chem. 2000 Jan 21;275(3):1829-38.


Heparan sulfate-modified CD44 promotes hepatocyte growth factor/scatter factor-induced signal transduction through the receptor tyrosine kinase c-Met.

van der Voort R, Taher TE, Wielenga VJ, Spaargaren M, Prevo R, Smit L, David G, Hartmann G, Gherardi E, Pals ST.

J Biol Chem. 1999 Mar 5;274(10):6499-506.


Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation.

Birukova AA, Zagranichnaya T, Fu P, Alekseeva E, Chen W, Jacobson JR, Birukov KG.

Exp Cell Res. 2007 Jul 1;313(11):2504-20. Epub 2007 Apr 6.


Hepatocyte growth factor triggers distinct mechanisms of Asef and Tiam1 activation to induce endothelial barrier enhancement.

Higginbotham K, Tian Y, Gawlak G, Moldobaeva N, Shah A, Birukova AA.

Cell Signal. 2014 Nov;26(11):2306-16. doi: 10.1016/j.cellsig.2014.07.032. Epub 2014 Aug 4.


Critical role of S1PR1 and integrin β4 in HGF/c-Met-mediated increases in vascular integrity.

Ephstein Y, Singleton PA, Chen W, Wang L, Salgia R, Kanteti P, Dudek SM, Garcia JG, Jacobson JR.

J Biol Chem. 2013 Jan 25;288(4):2191-200. doi: 10.1074/jbc.M112.404780. Epub 2012 Dec 4.


Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation.

Finigan JH, Dudek SM, Singleton PA, Chiang ET, Jacobson JR, Camp SM, Ye SQ, Garcia JG.

J Biol Chem. 2005 Apr 29;280(17):17286-93. Epub 2005 Feb 14.


High-molecular-weight hyaluronan is a novel inhibitor of pulmonary vascular leakiness.

Singleton PA, Mirzapoiazova T, Guo Y, Sammani S, Mambetsariev N, Lennon FE, Moreno-Vinasco L, Garcia JG.

Am J Physiol Lung Cell Mol Physiol. 2010 Nov;299(5):L639-51. doi: 10.1152/ajplung.00405.2009. Epub 2010 Aug 13.


CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro.

Su W, Gutmann DH, Perry A, Abounader R, Laterra J, Sherman LS.

Glia. 2004 Feb;45(3):297-306.


Hyaluronan-CD44 interaction stimulates Rac1 signaling and PKN gamma kinase activation leading to cytoskeleton function and cell migration in astrocytes.

Bourguignon LY, Gilad E, Peyrollier K, Brightman A, Swanson RA.

J Neurochem. 2007 May;101(4):1002-17. Epub 2007 Mar 30.


Growth and angiogenesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist.

Martin TA, Parr C, Davies G, Watkins G, Lane J, Matsumoto K, Nakamura T, Mansel RE, Jiang WG.

Carcinogenesis. 2003 Aug;24(8):1317-23. Epub 2003 May 9.


Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth.

Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton PA, Hung MC.

J Biol Chem. 2001 Dec 28;276(52):48679-92. Epub 2001 Oct 17.


CD44 stimulation induces integrin-mediated adhesion of colon cancer cell lines to endothelial cells by up-regulation of integrins and c-Met and activation of integrins.

Fujisaki T, Tanaka Y, Fujii K, Mine S, Saito K, Yamada S, Yamashita U, Irimura T, Eto S.

Cancer Res. 1999 Sep 1;59(17):4427-34.

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