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Role of medium-chain triglycerides in the alcohol-mediated cytochrome P450 2E1 induction of mitochondria.

Lieber CS, Cao Q, DeCarli LM, Leo MA, Mak KM, Ponomarenko A, Ren C, Wang X.

Alcohol Clin Exp Res. 2007 Oct;31(10):1660-8. Epub 2007 Aug 6.


Beneficial effects versus toxicity of medium-chain triacylglycerols in rats with NASH.

Lieber CS, DeCarli LM, Leo MA, Mak KM, Ponomarenko A, Ren C, Wang X.

J Hepatol. 2008 Feb;48(2):318-26. Epub 2007 Dec 10.


Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver.

Zhao P, Kalhorn TF, Slattery JT.

Hepatology. 2002 Aug;36(2):326-35.


Model of nonalcoholic steatohepatitis.

Lieber CS, Leo MA, Mak KM, Xu Y, Cao Q, Ren C, Ponomarenko A, DeCarli LM.

Am J Clin Nutr. 2004 Mar;79(3):502-9.


Attenuation of alcohol-induced apoptosis of hepatocytes in rat livers by polyenylphosphatidylcholine (PPC).

Mi LJ, Mak KM, Lieber CS.

Alcohol Clin Exp Res. 2000 Feb;24(2):207-12.


Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM.

Hepatology. 2011 Jul;54(1):153-63. doi: 10.1002/hep.24377.


Ethanol increases mitochondrial cytochrome P450 2E1 in mouse liver and rat hepatocytes.

Robin MA, Sauvage I, Grandperret T, Descatoire V, Pessayre D, Fromenty B.

FEBS Lett. 2005 Dec 19;579(30):6895-902. Epub 2005 Dec 1.


Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice.

Lu Y, Wu D, Wang X, Ward SC, Cederbaum AI.

Free Radic Biol Med. 2010 Nov 15;49(9):1406-16. doi: 10.1016/j.freeradbiomed.2010.07.026. Epub 2010 Aug 6.


CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis.

Abdelmegeed MA, Banerjee A, Jang S, Yoo SH, Yun JW, Gonzalez FJ, Keshavarzian A, Song BJ.

Free Radic Biol Med. 2013 Dec;65:1238-45. doi: 10.1016/j.freeradbiomed.2013.09.009. Epub 2013 Sep 21.


Chronic ethanol consumption in mice alters hepatocyte lipid droplet properties.

Orlicky DJ, Roede JR, Bales E, Greenwood C, Greenberg A, Petersen D, McManaman JL.

Alcohol Clin Exp Res. 2011 Jun;35(6):1020-33. doi: 10.1111/j.1530-0277.2011.01434.x. Epub 2011 Apr 27.


Medium chain triglycerides dose-dependently prevent liver pathology in a rat model of non-alcoholic fatty liver disease.

Ronis MJ, Baumgardner JN, Sharma N, Vantrease J, Ferguson M, Tong Y, Wu X, Cleves MA, Badger TM.

Exp Biol Med (Maywood). 2013 Feb;238(2):151-62. doi: 10.1258/ebm.2012.012303.


Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition.

Ronis MJ, Butura A, Sampey BP, Shankar K, Prior RL, Korourian S, Albano E, Ingelman-Sundberg M, Petersen DR, Badger TM.

Free Radic Biol Med. 2005 Sep 1;39(5):619-30.


Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition.

Ronis MJ, Korourian S, Zipperman M, Hakkak R, Badger TM.

J Nutr. 2004 Apr;134(4):904-12.


Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes.

Tang H, Sebastian BM, Axhemi A, Chen X, Hillian AD, Jacobsen DW, Nagy LE.

Alcohol Clin Exp Res. 2012 Feb;36(2):214-22. doi: 10.1111/j.1530-0277.2011.01607.x. Epub 2011 Sep 6.


Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats.

Wang Y, Seitz HK, Wang XD.

Alcohol Clin Exp Res. 2010 Mar 1;34(3):567-73. doi: 10.1111/j.1530-0277.2009.01122.x. Epub 2009 Dec 17.


Mitochondria-targeted cytochrome P450 2E1 induces oxidative damage and augments alcohol-mediated oxidative stress.

Bansal S, Liu CP, Sepuri NB, Anandatheerthavarada HK, Selvaraj V, Hoek J, Milne GL, Guengerich FP, Avadhani NG.

J Biol Chem. 2010 Aug 6;285(32):24609-19. doi: 10.1074/jbc.M110.121822. Epub 2010 Jun 7.


Preservation of hepatocyte nuclear factor-4α contributes to the beneficial effect of dietary medium chain triglyceride on alcohol-induced hepatic lipid dyshomeostasis in rats.

Li Q, Zhong W, Qiu Y, Kang X, Sun X, Tan X, Zhao Y, Sun X, Jia W, Zhou Z.

Alcohol Clin Exp Res. 2013 Apr;37(4):587-98. doi: 10.1111/acer.12013. Epub 2012 Nov 5.


Hepatotoxicity induced by iron overload and alcohol. Studies on the role of chelatable iron, cytochrome P450 2E1 and lipid peroxidation.

Stål P, Johansson I, Ingelman-Sundberg M, Hagen K, Hultcrantz R.

J Hepatol. 1996 Oct;25(4):538-46.


Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice.

Cao YW, Jiang Y, Zhang DY, Wang M, Chen WS, Su H, Wang YT, Wan JB.

J Ethnopharmacol. 2015 Feb 23;161:92-8. doi: 10.1016/j.jep.2014.12.013. Epub 2014 Dec 12.


Polyenylphosphatidylcholine opposes the increase of cytochrome P-4502E1 by ethanol and corrects its iron-induced decrease.

Aleynik MK, Leo MA, Aleynik SI, Lieber CS.

Alcohol Clin Exp Res. 1999 Jan;23(1):96-100.


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