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Items: 1 to 20 of 94

1.

Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays.

Myers MC, Napper AD, Motlekar N, Shah PP, Chiu CH, Beavers MP, Diamond SL, Huryn DM, Smith AB 3rd.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4761-6. Epub 2007 Jul 5.

3.

Design and synthesis of tetracyclic nonpeptidic biaryl nitrile inhibitors of cathepsin K.

Setti EL, Venkatraman S, Palmer JT, Xie X, Cheung H, Yu W, Wesolowski G, Robichaud J.

Bioorg Med Chem Lett. 2006 Aug 15;16(16):4296-9. Epub 2006 Jun 5.

PMID:
16750630
4.

Evaluation of an orthogonal pooling strategy for rapid high-throughput screening of proteases.

Motlekar N, Diamond SL, Napper AD.

Assay Drug Dev Technol. 2008 Jun;6(3):395-405. doi: 10.1089/adt.2007.110.

6.

Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.

Ménard R, Therrien C, Lachance P, Sulea T, Qo H, Alvarez-Hernandez AD, Roush WR.

Biol Chem. 2001 May;382(5):839-45.

PMID:
11517939
7.

Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.

Pillay CS, Dennison C.

Biol Chem. 2002 Jul-Aug;383(7-8):1199-204.

PMID:
12437106
8.
9.

Cys-His proteases are among the wired proteins of the cell.

Lockwood TD.

Arch Biochem Biophys. 2004 Dec 1;432(1):12-24.

PMID:
15519292
10.

Fluorogenic peptide substrates for carboxydipeptidase activity of cathepsin B.

Stachowiak K, Tokmina M, Karpińska A, Sosnowska R, Wiczk W.

Acta Biochim Pol. 2004;51(1):81-92.

11.

Strategy in inhibition of cathepsin B, a target in tumor invasion and metastasis.

Lim IT, Meroueh SO, Lee M, Heeg MJ, Mobashery S.

J Am Chem Soc. 2004 Aug 25;126(33):10271-7.

PMID:
15315439
12.

Development of dual-acting prodrugs for circumventing multidrug resistance.

Abu Ajaj K, Kratz F.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):995-1000. doi: 10.1016/j.bmcl.2008.11.063. Epub 2008 Nov 24.

PMID:
19131246
13.

Multi-conformation 3D QSAR study of benzenesulfonyl-pyrazol-ester compounds and their analogs as cathepsin B inhibitors.

Zhou Z, Wang Y, Bryant SH.

J Mol Graph Model. 2011 Sep;30:135-47. doi: 10.1016/j.jmgm.2011.06.013. Epub 2011 Jul 7.

14.

The identification of potent, selective, and bioavailable cathepsin S inhibitors.

Gauthier JY, Black WC, Courchesne I, Cromlish W, Desmarais S, Houle R, Lamontagne S, Li CS, Massé F, McKay DJ, Ouellet M, Robichaud J, Truchon JF, Truong VL, Wang Q, Percival MD.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4929-33. Epub 2007 Jun 10.

PMID:
17590332
15.

Cathepsin B, thiols and cysteine protease inhibitors in squamous-cell lung cancer.

Krepela E, Procházka J, Kárová B, Cermák J, Roubková H.

Neoplasma. 1997;44(4):219-39. Erratum in: Neoplasma 1997;44(5):333.

PMID:
9473776
16.

Potent inhibitors of Huntingtin protein aggregation in a cell-based assay.

Rinderspacher A, Cremona ML, Liu Y, Deng SX, Xie Y, Gong G, Aulner N, Többen U, Myers K, Chung C, Andersen M, Vidović D, Schürer S, Brandén L, Yamamoto A, Landry DW.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1715-7. doi: 10.1016/j.bmcl.2009.01.087. Epub 2009 Jan 30.

17.

Azapeptides as inhibitors and active site titrants for cysteine proteinases.

Xing R, Hanzlik RP.

J Med Chem. 1998 Apr 9;41(8):1344-51.

PMID:
9548822
18.
19.

Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors.

Kishore Kumar GD, Chavarria GE, Charlton-Sevcik AK, Arispe WM, Macdonough MT, Strecker TE, Chen SE, Siim BG, Chaplin DJ, Trawick ML, Pinney KG.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1415-9. doi: 10.1016/j.bmcl.2009.12.090. Epub 2010 Jan 6.

PMID:
20089402
20.

Inhibition of cholesteryl ester transfer protein by substituted dithiobisnicotinic acid dimethyl ester: involvement Of a critical cysteine.

Hope HR, Heuvelman D, Duffin K, Smith C, Zablocki J, Schilling R, Hegde S, Lee L, Witherbee B, Baganoff M, Bruce C, Tall AR, Krul E, Glenn K, Connolly DT.

J Lipid Res. 2000 Oct;41(10):1604-14.

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