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Keeping the (kinase) party going: SLP-76 and ITK dance to the beat.

Qi Q, August A.

Sci STKE. 2007 Jul 24;2007(396):pe39. Review.


SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.

Bogin Y, Ainey C, Beach D, Yablonski D.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6638-43. Epub 2007 Apr 9.


Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.

Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT.

EMBO J. 1999 Apr 1;18(7):1832-44.


Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.

J Biol Chem. 2000 Jan 21;275(3):2219-30.


Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.

Hussain A, Mohammad DK, Gustafsson MO, Uslu M, Hamasy A, Nore BF, Mohamed AJ, Smith CI.

J Biol Chem. 2013 Mar 8;288(10):7338-50. doi: 10.1074/jbc.M112.374967. Epub 2013 Jan 4.


Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells.

Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith-Garvin JE, Okumura M, Starosvetsky E, Kosoff R, Libman E, Koretzky G, Kambayashi T, Urlaub H, Wienands J, Chernoff J, Yablonski D.

EMBO J. 2011 Jul 1;30(15):3160-72. doi: 10.1038/emboj.2011.213.


T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.

Gonen R, Beach D, Ainey C, Yablonski D.

J Biol Chem. 2005 Mar 4;280(9):8364-70. Epub 2004 Dec 28.


Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1.

Beach D, Gonen R, Bogin Y, Reischl IG, Yablonski D.

J Biol Chem. 2007 Feb 2;282(5):2937-46. Epub 2006 Dec 4.


Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.

Min L, Joseph RE, Fulton DB, Andreotti AH.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21143-8. doi: 10.1073/pnas.0911309106. Epub 2009 Dec 1.


Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.

Yablonski D, Kuhne MR, Kadlecek T, Weiss A.

Science. 1998 Jul 17;281(5375):413-6.


Scaffold Protein SLP-76 Primes PLCĪ³1 for Activation by ITK-Mediated Phosphorylation.

Devkota S, Joseph RE, Min L, Bruce Fulton D, Andreotti AH.

J Mol Biol. 2015 Aug 28;427(17):2734-47. doi: 10.1016/j.jmb.2015.04.012. Epub 2015 Apr 25.


Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.

Bubeck Wardenburg J, Fu C, Jackman JK, Flotow H, Wilkinson SE, Williams DH, Johnson R, Kong G, Chan AC, Findell PR.

J Biol Chem. 1996 Aug 16;271(33):19641-4.


A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.

Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD.

PLoS One. 2012;7(9):e45158. doi: 10.1371/journal.pone.0045158. Epub 2012 Sep 18.


Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

Carrizosa E, Gomez TS, Labno CM, Klos Dehring DA, Liu X, Freedman BD, Billadeau DD, Burkhardt JK.

J Immunol. 2009 Dec 1;183(11):7352-61. doi: 10.4049/jimmunol.0900973. Epub 2009 Nov 16.


Interaction of SLP adaptors with the SH2 domain of Tec family kinases.

Su YW, Zhang Y, Schweikert J, Koretzky GA, Reth M, Wienands J.

Eur J Immunol. 1999 Nov;29(11):3702-11.

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