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Items: 1 to 20 of 122


ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism.

Ferguson JE 3rd, Wu Y, Smith K, Charles P, Powers K, Wang H, Patterson C.

Mol Cell Biol. 2007 Sep;27(18):6407-19. Epub 2007 Jul 16.


The ubiquitin ligase ASB4 promotes trophoblast differentiation through the degradation of ID2.

Townley-Tilson WH, Wu Y, Ferguson JE 3rd, Patterson C.

PLoS One. 2014 Feb 21;9(2):e89451. doi: 10.1371/journal.pone.0089451. eCollection 2014.


MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

Webb JD, Murányi A, Pugh CW, Ratcliffe PJ, Coleman ML.

Biochem J. 2009 May 13;420(2):327-33. doi: 10.1042/BJ20081905.


Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Cockman ME, Webb JD, Kramer HB, Kessler BM, Ratcliffe PJ.

Mol Cell Proteomics. 2009 Mar;8(3):535-46. doi: 10.1074/mcp.M800340-MCP200. Epub 2008 Oct 20.


Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor.

Linke S, Stojkoski C, Kewley RJ, Booker GW, Whitelaw ML, Peet DJ.

J Biol Chem. 2004 Apr 2;279(14):14391-7. Epub 2004 Jan 20.


Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).

Wilkins SE, Hyvärinen J, Chicher J, Gorman JJ, Peet DJ, Bilton RL, Koivunen P.

Int J Biochem Cell Biol. 2009 Jul;41(7):1563-71. doi: 10.1016/j.biocel.2009.01.005. Epub 2009 Jan 20.


Factor inhibiting HIF (FIH) recognizes distinct molecular features within hypoxia-inducible factor-α (HIF-α) versus ankyrin repeat substrates.

Wilkins SE, Karttunen S, Hampton-Smith RJ, Murchland I, Chapman-Smith A, Peet DJ.

J Biol Chem. 2012 Mar 16;287(12):8769-81. doi: 10.1074/jbc.M111.294678. Epub 2012 Jan 23.


Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Hewitson KS, Schofield CJ, Ratcliffe PJ.

Methods Enzymol. 2007;435:25-42.


Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.

Hardy AP, Prokes I, Kelly L, Campbell ID, Schofield CJ.

J Mol Biol. 2009 Oct 2;392(4):994-1006. doi: 10.1016/j.jmb.2009.07.070. Epub 2009 Jul 30.


Quantitative proteomics analysis demonstrates post-transcriptional regulation of embryonic stem cell differentiation to hematopoiesis.

Williamson AJ, Smith DL, Blinco D, Unwin RD, Pearson S, Wilson C, Miller C, Lancashire L, Lacaud G, Kouskoff V, Whetton AD.

Mol Cell Proteomics. 2008 Mar;7(3):459-72. Epub 2007 Nov 27.


The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.

Linossi EM, Nicholson SE.

IUBMB Life. 2012 Apr;64(4):316-23. doi: 10.1002/iub.1011. Epub 2012 Feb 23. Review.


Substrate-mediated regulation of cullin neddylation.

Chew EH, Hagen T.

J Biol Chem. 2007 Jun 8;282(23):17032-40. Epub 2007 Apr 17.


Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases.

Flashman E, Bagg EA, Chowdhury R, Mecinović J, Loenarz C, McDonough MA, Hewitson KS, Schofield CJ.

J Biol Chem. 2008 Feb 15;283(7):3808-15. Epub 2007 Dec 5.


Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases.

Muniz JR, Guo K, Kershaw NJ, Ayinampudi V, von Delft F, Babon JJ, Bullock AN.

J Mol Biol. 2013 Sep 9;425(17):3166-77. doi: 10.1016/j.jmb.2013.06.015. Epub 2013 Jun 25.


Regulation of HIF: asparaginyl hydroxylation.

Peet D, Linke S.

Novartis Found Symp. 2006;272:37-49; discussion 49-53, 131-40. Review.


Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel.

Karttunen S, Duffield M, Scrimgeour NR, Squires L, Lim WL, Dallas ML, Scragg JL, Chicher J, Dave KA, Whitelaw ML, Peers C, Gorman JJ, Gleadle JM, Rychkov GY, Peet DJ.

J Cell Sci. 2015 Jan 15;128(2):225-31. doi: 10.1242/jcs.158451. Epub 2014 Nov 20.


Proteome alteration of early-stage differentiation of mouse embryonic stem cells into hepatocyte-like cells.

Li Y, Kang X, Guo K, Li X, Gao D, Cui J, Sun L, Yang P, Liu Y.

Electrophoresis. 2009 May;30(9):1431-40. doi: 10.1002/elps.200800836.


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