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Matrix synthesis and degradation in human intervertebral disc degeneration.

Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ, Hoyland JA.

Biochem Soc Trans. 2007 Aug;35(Pt 4):652-5. Review.


TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc.

Wang J, Markova D, Anderson DG, Zheng Z, Shapiro IM, Risbud MV.

J Biol Chem. 2011 Nov 18;286(46):39738-49. doi: 10.1074/jbc.M111.264549. Epub 2011 Sep 23.


The Changes in the Expression of NF-KB in a Degenerative Human Intervertebral Disc model.

Sun Z, Yin Z, Liu C, Tian J.

Cell Biochem Biophys. 2015 May;72(1):115-22. doi: 10.1007/s12013-014-0417-3.


Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration.

Pockert AJ, Richardson SM, Le Maitre CL, Lyon M, Deakin JA, Buttle DJ, Freemont AJ, Hoyland JA.

Arthritis Rheum. 2009 Feb;60(2):482-91. doi: 10.1002/art.24291.


Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc.

Le Maitre CL, Freemont AJ, Hoyland JA.

J Pathol. 2004 Sep;204(1):47-54.


MicroRNA-146a reduces IL-1 dependent inflammatory responses in the intervertebral disc.

Gu SX, Li X, Hamilton JL, Chee A, Kc R, Chen D, An HS, Kim JS, Oh CD, Ma YZ, van Wijnen AJ, Im HJ.

Gene. 2015 Jan 25;555(2):80-7. doi: 10.1016/j.gene.2014.10.024. Epub 2014 Oct 12.


Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration.

Vo NV, Hartman RA, Yurube T, Jacobs LJ, Sowa GA, Kang JD.

Spine J. 2013 Mar;13(3):331-41. doi: 10.1016/j.spinee.2012.02.027. Epub 2013 Jan 29. Review.


The Effects of Platelet-Rich Plasma on Halting the Progression in Porcine Intervertebral Disc Degeneration.

Cho H, Holt DC 3rd, Smith R, Kim SJ, Gardocki RJ, Hasty KA.

Artif Organs. 2016 Feb;40(2):190-5. doi: 10.1111/aor.12530. Epub 2015 Jul 6.


p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1.

Studer RK, Gilbertson LG, Georgescu H, Sowa G, Vo N, Kang JD.

J Orthop Res. 2008 Jul;26(7):991-8. doi: 10.1002/jor.20604.


Increased expression of matrix metalloproteinase-10, nerve growth factor and substance P in the painful degenerate intervertebral disc.

Richardson SM, Doyle P, Minogue BM, Gnanalingham K, Hoyland JA.

Arthritis Res Ther. 2009;11(4):R126. doi: 10.1186/ar2793. Epub 2009 Aug 20.


Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration.

Séguin CA, Bojarski M, Pilliar RM, Roughley PJ, Kandel RA.

Matrix Biol. 2006 Sep;25(7):409-18. Epub 2006 Aug 23.


Best paper NASS 2013: link-N can stimulate proteoglycan synthesis in the degenerated human intervertebral discs.

Gawri R, Antoniou J, Ouellet J, Awwad W, Steffen T, Roughley P, Haglund L, Mwale F.

Eur Cell Mater. 2013 Sep 11;26:107-19; discussion 119.


Lactoferricin mediates anabolic and anti-catabolic effects in the intervertebral disc.

Kim JS, Ellman MB, An HS, Yan D, van Wijnen AJ, Murphy G, Hoskin DW, Im HJ.

J Cell Physiol. 2012 Apr;227(4):1512-20. doi: 10.1002/jcp.22867.


Crocin exerts anti-inflammatory and anti-catabolic effects on rat intervertebral discs by suppressing the activation of JNK.

Li K, Li Y, Ma Z, Zhao J.

Int J Mol Med. 2015 Nov;36(5):1291-9. doi: 10.3892/ijmm.2015.2359. Epub 2015 Sep 30.


Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration.

Millward-Sadler SJ, Costello PW, Freemont AJ, Hoyland JA.

Arthritis Res Ther. 2009;11(3):R65. doi: 10.1186/ar2693. Epub 2009 May 12.


Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration.

Hu B, Shi C, Xu C, Cao P, Tian Y, Zhang Y, Deng L, Chen H, Yuan W.

Sci Rep. 2016 Feb 15;6:21190. doi: 10.1038/srep21190.

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