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Items: 1 to 20 of 137

1.

Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD).

Taylor PA, Ehrhardt MJ, Lees CJ, Tolar J, Weigel BJ, Panoskaltsis-Mortari A, Serody JS, Brinkmann V, Blazar BR.

Blood. 2007 Nov 1;110(9):3480-8. Epub 2007 Jul 2.

2.

FTY720 markedly increases alloengraftment but does not eliminate host anti-donor T cells that cause graft rejection on its withdrawal.

Taylor PA, Kelly RM, Bade ND, Smith MJ, Stefanski HE, Blazar BR.

Biol Blood Marrow Transplant. 2012 Sep;18(9):1341-52. doi: 10.1016/j.bbmt.2012.06.007. Epub 2012 Jun 19.

3.

FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin.

Huu DL, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M.

Arthritis Rheum. 2013 Jun;65(6):1624-35. doi: 10.1002/art.37933.

4.

Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.

Kim YM, Sachs T, Asavaroengchai W, Bronson R, Sykes M.

J Clin Invest. 2003 Mar;111(5):659-69.

5.

FTY720 exerts differential effects on CD4+ and CD8+ T-lymphocyte subpopulations expressing chemokine and adhesion receptors.

Böhler T, Waiser J, Schuetz M, Neumayer HH, Budde K.

Nephrol Dial Transplant. 2004 Mar;19(3):702-13.

PMID:
14767029
6.

Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-versus-host disease in small bowel transplantation.

Song J, Ito T, Matsuda C, Miao G, Tanemura M, Nishida T, Nozawa M, Matsuda H, Sawa Y.

Clin Exp Immunol. 2006 Oct;146(1):85-92.

7.

Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM).

Taylor PA, Panoskaltsis-Mortari A, Freeman GJ, Sharpe AH, Noelle RJ, Rudensky AY, Mak TW, Serody JS, Blazar BR.

Blood. 2005 Apr 15;105(8):3372-80. Epub 2004 Dec 23.

8.

HY-Specific Induced Regulatory T Cells Display High Specificity and Efficacy in the Prevention of Acute Graft-versus-Host Disease.

Li J, Heinrichs J, Haarberg K, Semple K, Veerapathran A, Liu C, Anasetti C, Yu XZ.

J Immunol. 2015 Jul 15;195(2):717-25. doi: 10.4049/jimmunol.1401250. Epub 2015 Jun 5.

9.

FTY720 enhances the activation-induced apoptosis of donor T cells and modulates graft-versus-host disease.

Hashimoto D, Asakura S, Matsuoka K, Sakoda Y, Koyama M, Aoyama K, Tanimoto M, Teshima T.

Eur J Immunol. 2007 Jan;37(1):271-81.

10.

Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure.

Metzler B, Gfeller P, Wieczorek G, Li J, Nuesslein-Hildesheim B, Katopodis A, Mueller M, Brinkmann V.

Int Immunol. 2008 May;20(5):633-44. doi: 10.1093/intimm/dxn023. Epub 2008 Mar 14.

PMID:
18343890
11.

Regulation of donor T cells in the tolerant rats to graft-versus-host disease by FTY720 following small bowel transplantation.

Song J, Ito T, Matsuda C, Tanemura M, Nishida T, Nozawa M, Sawa Y.

Transplant Proc. 2006 Dec;38(10):3181-3.

PMID:
17175216
12.

Accumulation of fingolimod (FTY720) in lymphoid tissues contributes to prolonged efficacy.

Sensken SC, Bode C, Gräler MH.

J Pharmacol Exp Ther. 2009 Mar;328(3):963-9. doi: 10.1124/jpet.108.148163. Epub 2008 Dec 12.

13.

FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigen-nonidentical unrelated canine model.

Lee RS, Kuhr CS, Sale GE, Zellmer E, Hogan WJ, Storb R, Little MT.

Transplantation. 2003 Oct 27;76(8):1155-8.

PMID:
14578745
15.
16.

FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway.

Ntranos A, Hall O, Robinson DP, Grishkan IV, Schott JT, Tosi DM, Klein SL, Calabresi PA, Gocke AR.

J Neuroimmunol. 2014 May 15;270(1-2):13-21. doi: 10.1016/j.jneuroim.2014.03.007. Epub 2014 Mar 11.

PMID:
24680062
17.

The role of purified CD8+ T cells in graft-versus-leukemia activity and engraftment after allogeneic bone marrow transplantation.

Palathumpat V, Dejbakhsh-Jones S, Strober S.

Transplantation. 1995 Aug 27;60(4):355-61.

PMID:
7652765
18.

Differential Effect of MyD88 Signal in Donor T Cells on Graft-versus-Leukemia Effect and Graft-versus-Host Disease after Experimental Allogeneic Stem Cell Transplantation.

Lim JY, Ryu DB, Lee SE, Park G, Choi EY, Min CK.

Mol Cells. 2015 Nov;38(11):966-74. doi: 10.14348/molcells.2015.0158. Epub 2015 Nov 10.

19.

The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.

Sawicka E, Dubois G, Jarai G, Edwards M, Thomas M, Nicholls A, Albert R, Newson C, Brinkmann V, Walker C.

J Immunol. 2005 Dec 15;175(12):7973-80.

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