Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 72

1.

Common variants in WFS1 confer risk of type 2 diabetes.

Sandhu MS, Weedon MN, Fawcett KA, Wasson J, Debenham SL, Daly A, Lango H, Frayling TM, Neumann RJ, Sherva R, Blech I, Pharoah PD, Palmer CN, Kimber C, Tavendale R, Morris AD, McCarthy MI, Walker M, Hitman G, Glaser B, Permutt MA, Hattersley AT, Wareham NJ, Barroso I.

Nat Genet. 2007 Aug;39(8):951-3. Epub 2007 Jul 1.

2.

Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.

Franks PW, Rolandsson O, Debenham SL, Fawcett KA, Payne F, Dina C, Froguel P, Mohlke KL, Willer C, Olsson T, Wareham NJ, Hallmans G, Barroso I, Sandhu MS.

Diabetologia. 2008 Mar;51(3):458-63. Epub 2007 Nov 27. Erratum in: Diabetologia. 2008 Mar;51(3):523.

3.
4.

Detailed investigation of the role of common and low-frequency WFS1 variants in type 2 diabetes risk.

Fawcett KA, Wheeler E, Morris AP, Ricketts SL, Hallmans G, Rolandsson O, Daly A, Wasson J, Permutt A, Hattersley AT, Glaser B, Franks PW, McCarthy MI, Wareham NJ, Sandhu MS, Barroso I.

Diabetes. 2010 Mar;59(3):741-6. doi: 10.2337/db09-0920. Epub 2009 Dec 22.

5.

Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population.

Mita M, Miyake K, Zenibayashi M, Hirota Y, Teranishi T, Kouyama K, Sakaguchi K, Kasuga M.

Kobe J Med Sci. 2008 Oct 30;54(4):E192-9.

6.

Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice.

Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, Saito T, Shinoda K, Oka Y, Tanizawa Y.

Diabetologia. 2009 Apr;52(4):653-63. doi: 10.1007/s00125-009-1270-6. Epub 2009 Feb 4.

PMID:
19190890
7.

Association of variants in genes involved in pancreatic β-cell development and function with type 2 diabetes in North Indians.

Chavali S, Mahajan A, Tabassum R, Dwivedi OP, Chauhan G, Ghosh S, Tandon N, Bharadwaj D.

J Hum Genet. 2011 Oct;56(10):695-700. doi: 10.1038/jhg.2011.83. Epub 2011 Aug 4.

PMID:
21814221
8.

Micro-RNA Binding Site Polymorphisms in the WFS1 Gene Are Risk Factors of Diabetes Mellitus.

Elek Z, Németh N, Nagy G, Németh H, Somogyi A, Hosszufalusi N, Sasvári-Székely M, Rónai Z.

PLoS One. 2015 Oct 1;10(10):e0139519. doi: 10.1371/journal.pone.0139519. eCollection 2015.

9.

Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.

Florez JC, Jablonski KA, McAteer J, Sandhu MS, Wareham NJ, Barroso I, Franks PW, Altshuler D, Knowler WC; Diabetes Prevention Program Research Group.

Diabetologia. 2008 Mar;51(3):451-7. Epub 2007 Dec 4.

10.

Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.

Neuman RJ, Wasson J, Atzmon G, Wainstein J, Yerushalmi Y, Cohen J, Barzilai N, Blech I, Glaser B, Permutt MA.

PLoS One. 2010 Mar 26;5(3):e9903. doi: 10.1371/journal.pone.0009903.

11.

Impact of polymorphisms in WFS1 on prediabetic phenotypes in a population-based sample of middle-aged people with normal and abnormal glucose regulation.

Sparsø T, Andersen G, Albrechtsen A, Jørgensen T, Borch-Johnsen K, Sandbaek A, Lauritzen T, Wasson J, Permutt MA, Glaser B, Madsbad S, Pedersen O, Hansen T.

Diabetologia. 2008 Sep;51(9):1646-52. doi: 10.1007/s00125-008-1064-2. Epub 2008 Jun 21.

PMID:
18568334
12.

Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion.

Heni M, Ketterer C, Thamer C, Herzberg-Schäfer SA, Guthoff M, Stefan N, Machicao F, Staiger H, Fritsche A, Häring HU.

Diabetes. 2010 Dec;59(12):3247-52. doi: 10.2337/db10-0674. Epub 2010 Aug 29.

13.

A WFS1 haplotype consisting of the minor alleles of rs752854, rs10010131, and rs734312 shows a protective role against type 2 diabetes in Russian patients.

Chistiakov DA, Khodyrev DS, Smetanina SA, Bel'chikova LN, Suplotova LA, Nosikov VV.

Rev Diabet Stud. 2010 Winter;7(4):285-92. doi: 10.1900/RDS.2010.7.285. Epub 2011 Feb 10.

14.

Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

Han X, Luo Y, Ren Q, Zhang X, Wang F, Sun X, Zhou X, Ji L.

BMC Med Genet. 2010 May 28;11:81. doi: 10.1186/1471-2350-11-81.

15.

Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis.

Riggs AC, Bernal-Mizrachi E, Ohsugi M, Wasson J, Fatrai S, Welling C, Murray J, Schmidt RE, Herrera PL, Permutt MA.

Diabetologia. 2005 Nov;48(11):2313-21. Epub 2005 Oct 8.

PMID:
16215705
16.

A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion.

Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A.

Diabetologia. 2009 Jun;52(6):1075-82. doi: 10.1007/s00125-009-1344-5. Epub 2009 Mar 28.

PMID:
19330314
17.

Genetic variations in the WFS1 gene in Japanese with type 2 diabetes and bipolar disorder.

Kawamoto T, Horikawa Y, Tanaka T, Kabe N, Takeda J, Mikuni M.

Mol Genet Metab. 2004 Jul;82(3):238-45.

PMID:
15234338
18.

WFS1 mutations are frequent monogenic causes of juvenile-onset diabetes mellitus in Lebanon.

Zalloua PA, Azar ST, Delépine M, Makhoul NJ, Blanc H, Sanyoura M, Lavergne A, Stankov K, Lemainque A, Baz P, Julier C.

Hum Mol Genet. 2008 Dec 15;17(24):4012-21. doi: 10.1093/hmg/ddn304. Epub 2008 Sep 20.

PMID:
18806274
19.

Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells.

Hatanaka M, Tanabe K, Yanai A, Ohta Y, Kondo M, Akiyama M, Shinoda K, Oka Y, Tanizawa Y.

Hum Mol Genet. 2011 Apr 1;20(7):1274-84. doi: 10.1093/hmg/ddq568. Epub 2011 Jan 3.

PMID:
21199859
20.

WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells.

Fonseca SG, Fukuma M, Lipson KL, Nguyen LX, Allen JR, Oka Y, Urano F.

J Biol Chem. 2005 Nov 25;280(47):39609-15. Epub 2005 Sep 29.

Supplemental Content

Support Center