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Items: 1 to 20 of 1017

1.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

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3.

mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.

Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.

J Endocrinol. 2013 Jan 2;216(1):21-9. doi: 10.1530/JOE-12-0351. Print 2013 Jan.

4.

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.

Int J Oncol. 2009 Oct;35(4):731-40.

PMID:
19724909
5.

PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis.

Thedieck K, Polak P, Kim ML, Molle KD, Cohen A, Jenö P, Arrieumerlou C, Hall MN.

PLoS One. 2007 Nov 21;2(11):e1217.

6.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

7.

Raptor-rictor axis in TGFbeta-induced protein synthesis.

Das F, Ghosh-Choudhury N, Mahimainathan L, Venkatesan B, Feliers D, Riley DJ, Kasinath BS, Choudhury GG.

Cell Signal. 2008 Feb;20(2):409-23. Epub 2007 Nov 7.

PMID:
18068336
8.

IKK interacts with rictor and regulates mTORC2.

Xu Y, Lai E, Liu J, Lin J, Yang C, Jia C, Li Y, Bai X, Li M.

Cell Signal. 2013 Nov;25(11):2239-45. doi: 10.1016/j.cellsig.2013.07.008. Epub 2013 Jul 17.

PMID:
23872070
9.

SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity.

Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B.

Cell. 2006 Oct 6;127(1):125-37. Epub 2006 Sep 7.

10.

mTOR phosphorylated at S2448 binds to raptor and rictor.

Rosner M, Siegel N, Valli A, Fuchs C, Hengstschläger M.

Amino Acids. 2010 Jan;38(1):223-8. doi: 10.1007/s00726-008-0230-7. Epub 2009 Jan 15.

PMID:
19145465
11.

Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways.

Wang S, Amato KR, Song W, Youngblood V, Lee K, Boothby M, Brantley-Sieders DM, Chen J.

Mol Cell Biol. 2015 Apr;35(7):1299-313. doi: 10.1128/MCB.00306-14. Epub 2015 Jan 12.

12.

Autoregulation of the mechanistic target of rapamycin (mTOR) complex 2 integrity is controlled by an ATP-dependent mechanism.

Chen CH, Kiyan V, Zhylkibayev AA, Kazyken D, Bulgakova O, Page KE, Bersimbaev RI, Spooner E, Sarbassov dos D.

J Biol Chem. 2013 Sep 20;288(38):27019-30. doi: 10.1074/jbc.M113.498055. Epub 2013 Aug 8.

13.

Regulation of mTORC1 and mTORC2 complex assembly by phosphatidic acid: competition with rapamycin.

Toschi A, Lee E, Xu L, Garcia A, Gadir N, Foster DA.

Mol Cell Biol. 2009 Mar;29(6):1411-20. doi: 10.1128/MCB.00782-08. Epub 2008 Dec 29.

14.

Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.

Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H, Han X, Huang S.

J Biol Chem. 2010 Dec 3;285(49):38362-73. doi: 10.1074/jbc.M110.141168. Epub 2010 Oct 11.

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1.

Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM.

Dev Cell. 2006 Dec;11(6):859-71.

17.

Rapamycin regulates the phosphorylation of rictor.

Akcakanat A, Singh G, Hung MC, Meric-Bernstam F.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):330-3. Epub 2007 Aug 8.

18.

Role of PRAS40 in Akt and mTOR signaling in health and disease.

Wiza C, Nascimento EB, Ouwens DM.

Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1453-60. doi: 10.1152/ajpendo.00660.2011. Epub 2012 Feb 21.

PMID:
22354785
19.

ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells.

Fuchs BC, Finger RE, Onan MC, Bode BP.

Am J Physiol Cell Physiol. 2007 Jul;293(1):C55-63. Epub 2007 Feb 28.

PMID:
17329400
20.

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells.

Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.

Cell Signal. 2014 Mar;26(3):461-7. doi: 10.1016/j.cellsig.2013.11.035. Epub 2013 Dec 3.

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