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Items: 1 to 20 of 149

1.

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy.

Chan EY, Kir S, Tooze SA.

J Biol Chem. 2007 Aug 31;282(35):25464-74. Epub 2007 Jun 26.

2.

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells.

Aryal P, Kim K, Park PH, Ham S, Cho J, Song K.

FEBS J. 2014 Oct;281(20):4644-58. doi: 10.1111/febs.12969. Epub 2014 Sep 11.

3.

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates.

Egan DF, Chun MG, Vamos M, Zou H, Rong J, Miller CJ, Lou HJ, Raveendra-Panickar D, Yang CC, Sheffler DJ, Teriete P, Asara JM, Turk BE, Cosford ND, Shaw RJ.

Mol Cell. 2015 Jul 16;59(2):285-97. doi: 10.1016/j.molcel.2015.05.031. Epub 2015 Jun 25.

4.

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N, Mizushima N.

Mol Biol Cell. 2009 Apr;20(7):1981-91. doi: 10.1091/mbc.E08-12-1248. Epub 2009 Feb 11.

5.

The serine/threonine kinase ULK1 is a target of multiple phosphorylation events.

Bach M, Larance M, James DE, Ramm G.

Biochem J. 2011 Dec 1;440(2):283-91. doi: 10.1042/BJ20101894.

PMID:
21819378
6.

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1.

Kim J, Kundu M, Viollet B, Guan KL.

Nat Cell Biol. 2011 Feb;13(2):132-41. doi: 10.1038/ncb2152. Epub 2011 Jan 23.

7.
8.

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.

Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X.

J Biol Chem. 2009 May 1;284(18):12297-305. doi: 10.1074/jbc.M900573200. Epub 2009 Mar 3.

9.

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.

Jung CH, Seo M, Otto NM, Kim DH.

Autophagy. 2011 Oct;7(10):1212-21. doi: 10.4161/auto.7.10.16660. Epub 2011 Oct 1.

10.

Unc-51 like kinase 1 (ULK1) in silico analysis for biomarker identification: a vital component of autophagy.

Randhawa R, Sehgal M, Singh TR, Duseja A, Changotra H.

Gene. 2015 May 10;562(1):40-9. doi: 10.1016/j.gene.2015.02.056. Epub 2015 Feb 19.

PMID:
25701603
11.

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism.

Chan EY, Longatti A, McKnight NC, Tooze SA.

Mol Cell Biol. 2009 Jan;29(1):157-71. doi: 10.1128/MCB.01082-08. Epub 2008 Oct 20.

12.

Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy.

Kraft C, Kijanska M, Kalie E, Siergiejuk E, Lee SS, Semplicio G, Stoffel I, Brezovich A, Verma M, Hansmann I, Ammerer G, Hofmann K, Tooze S, Peter M.

EMBO J. 2012 Sep 12;31(18):3691-703. doi: 10.1038/emboj.2012.225. Epub 2012 Aug 10.

13.

The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR.

Egan D, Kim J, Shaw RJ, Guan KL.

Autophagy. 2011 Jun;7(6):643-4. Epub 2011 Jun 1.

14.

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK.

Shang L, Chen S, Du F, Li S, Zhao L, Wang X.

Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4788-93. doi: 10.1073/pnas.1100844108. Epub 2011 Mar 7.

15.

The association of AMPK with ULK1 regulates autophagy.

Lee JW, Park S, Takahashi Y, Wang HG.

PLoS One. 2010 Nov 3;5(11):e15394. doi: 10.1371/journal.pone.0015394.

16.

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2.

McAlpine F, Williamson LE, Tooze SA, Chan EY.

Autophagy. 2013 Mar;9(3):361-73. doi: 10.4161/auto.23066. Epub 2013 Jan 4.

17.

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery.

Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M, Kim DH.

Mol Biol Cell. 2009 Apr;20(7):1992-2003. doi: 10.1091/mbc.E08-12-1249. Epub 2009 Feb 18.

18.

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.

Gao W, Shen Z, Shang L, Wang X.

Cell Death Differ. 2011 Oct;18(10):1598-607. doi: 10.1038/cdd.2011.33. Epub 2011 Apr 8.

19.

Regulation of the autophagy initiating kinase ULK1 by nutrients: roles of mTORC1 and AMPK.

Kim J, Guan KL.

Cell Cycle. 2011 May 1;10(9):1337-8. doi: 10.4161/cc.10.9.15291. Epub 2011 Mar 15.

PMID:
21403467
20.

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