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Items: 1 to 20 of 330

1.

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2007 Aug 17;282(33):24131-45.

2.

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T.

J Cell Biol. 2005 Nov 21;171(4):603-14.

3.
4.

The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin.

Tung YT, Hsu WM, Lee H, Huang WP, Liao YF.

Cell Mol Neurobiol. 2010 Jul;30(5):795-806. doi: 10.1007/s10571-010-9507-y.

PMID:
20204693
5.

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.

Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T.

Autophagy. 2010 Apr;6(3):330-44.

PMID:
20168092
6.

Monitoring autophagic degradation of p62/SQSTM1.

Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T.

Methods Enzymol. 2009;452:181-97. doi: 10.1016/S0076-6879(08)03612-4.

PMID:
19200883
7.

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T.

Mol Cell. 2009 Feb 27;33(4):505-16. doi: 10.1016/j.molcel.2009.01.020.

8.

NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets.

Lamark T, Kirkin V, Dikic I, Johansen T.

Cell Cycle. 2009 Jul 1;8(13):1986-90.

PMID:
19502794
9.

The selective autophagy receptor p62 forms a flexible filamentous helical scaffold.

Ciuffa R, Lamark T, Tarafder AK, Guesdon A, Rybina S, Hagen WJ, Johansen T, Sachse C.

Cell Rep. 2015 May 5;11(5):748-58. doi: 10.1016/j.celrep.2015.03.062.

10.

p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription.

Jain A, Lamark T, Sjøttem E, Larsen KB, Awuh JA, Øvervatn A, McMahon M, Hayes JD, Johansen T.

J Biol Chem. 2010 Jul 16;285(29):22576-91. doi: 10.1074/jbc.M110.118976.

11.

NBR1 cooperates with p62 in selective autophagy of ubiquitinated targets.

Kirkin V, Lamark T, Johansen T, Dikic I.

Autophagy. 2009 Jul;5(5):732-3.

PMID:
19398892
12.
13.

Selective turnover of p62/A170/SQSTM1 by autophagy.

Ichimura Y, Kominami E, Tanaka K, Komatsu M.

Autophagy. 2008 Nov;4(8):1063-6.

PMID:
18776737
14.

Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.

Matsumoto G, Wada K, Okuno M, Kurosawa M, Nukina N.

Mol Cell. 2011 Oct 21;44(2):279-89. doi: 10.1016/j.molcel.2011.07.039.

15.

Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis.

Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes CJ, Evans TD, Arif B, Curci JA, Razani B.

Sci Signal. 2016 Jan 5;9(409):ra2. doi: 10.1126/scisignal.aad5614.

16.

Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.

Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q.

Autophagy. 2010 Jul;6(5):614-21. doi: 10.4161/auto.6.5.12189.

17.

Structural basis for sorting mechanism of p62 in selective autophagy.

Ichimura Y, Kumanomidou T, Sou YS, Mizushima T, Ezaki J, Ueno T, Kominami E, Yamane T, Tanaka K, Komatsu M.

J Biol Chem. 2008 Aug 15;283(33):22847-57. doi: 10.1074/jbc.M802182200.

18.

The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes.

Shvets E, Fass E, Scherz-Shouval R, Elazar Z.

J Cell Sci. 2008 Aug 15;121(Pt 16):2685-95. doi: 10.1242/jcs.026005.

19.

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation.

Fujita K, Maeda D, Xiao Q, Srinivasula SM.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1427-32. doi: 10.1073/pnas.1014156108.

20.

E1-like activating enzyme Atg7 is preferentially sequestered into p62 aggregates via its interaction with LC3-I.

Gao W, Chen Z, Wang W, Stang MT.

PLoS One. 2013 Sep 4;8(9):e73229. doi: 10.1371/journal.pone.0073229.

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