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BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy.

Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF.

Mol Cell Biol. 2007 Sep;27(17):6229-42. Epub 2007 Jun 18.


Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival.

Shaw J, Yurkova N, Zhang T, Gang H, Aguilar F, Weidman D, Scramstad C, Weisman H, Kirshenbaum LA.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20734-9. doi: 10.1073/pnas.0807735105. Epub 2008 Dec 16.


Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains.

Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouysségur J, Mazure NM.

Mol Cell Biol. 2009 May;29(10):2570-81. doi: 10.1128/MCB.00166-09. Epub 2009 Mar 9.


The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes.

Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, Kirshenbaum LA.

Circ Res. 2008 Feb 29;102(4):472-9. Epub 2007 Dec 20.


Regulation of mitochondrial integrity, autophagy and cell survival by BNIP3.

Tracy K, Macleod KF.

Autophagy. 2007 Nov-Dec;3(6):616-9. Epub 2007 Aug 15.


The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element.

Farrall AL, Whitelaw ML.

Oncogene. 2009 Oct 15;28(41):3671-80. doi: 10.1038/onc.2009.228. Epub 2009 Aug 10.


Role of BNIP3 and NIX in cell death, autophagy, and mitophagy.

Zhang J, Ney PA.

Cell Death Differ. 2009 Jul;16(7):939-46. doi: 10.1038/cdd.2009.16. Epub 2009 Feb 20. Review.


Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

Papandreou I, Lim AL, Laderoute K, Denko NC.

Cell Death Differ. 2008 Oct;15(10):1572-81. doi: 10.1038/cdd.2008.84. Epub 2008 Jun 13.


Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.

An HJ, Maeng O, Kang KH, Lee JO, Kim YS, Paik SG, Lee H.

J Biol Chem. 2006 Nov 10;281(45):33939-48. Epub 2006 Sep 5.


Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies.

Azad MB, Gibson SB.

Ann N Y Acad Sci. 2010 Oct;1210:8-16. doi: 10.1111/j.1749-6632.2010.05778.x.


BNIP3 subfamily BH3-only proteins: mitochondrial stress sensors in normal and pathological functions.

Chinnadurai G, Vijayalingam S, Gibson SB.

Oncogene. 2008 Dec;27 Suppl 1:S114-27. doi: 10.1038/onc.2009.49. Review.


p53 mediates autophagy and cell death by a mechanism contingent on Bnip3.

Wang EY, Gang H, Aviv Y, Dhingra R, Margulets V, Kirshenbaum LA.

Hypertension. 2013 Jul;62(1):70-7. doi: 10.1161/HYPERTENSIONAHA.113.01028. Epub 2013 May 6.


Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation.

Wu SY, Lan SH, Cheng DE, Chen WK, Shen CH, Lee YR, Zuchini R, Liu HS.

Neoplasia. 2011 Dec;13(12):1171-82.


Expression and subcellular localization of BNIP3 in hypoxic hepatocytes and liver stress.

Metukuri MR, Beer-Stolz D, Namas RA, Dhupar R, Torres A, Loughran PA, Jefferson BS, Tsung A, Billiar TR, Vodovotz Y, Zamora R.

Am J Physiol Gastrointest Liver Physiol. 2009 Mar;296(3):G499-509. doi: 10.1152/ajpgi.90526.2008. Epub 2009 Jan 15.


BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.

Kothari S, Cizeau J, McMillan-Ward E, Israels SJ, Bailes M, Ens K, Kirshenbaum LA, Gibson SB.

Oncogene. 2003 Jul 24;22(30):4734-44.


Mitochondrial autophagy: life and breath of the cell.

Semenza GL.

Autophagy. 2008 May;4(4):534-6. Epub 2008 Mar 25.


Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3.

Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ, Gibson SB.

Autophagy. 2008 Feb;4(2):195-204. Epub 2007 Nov 8.


Autophagy regulates hypoxia-induced osteoclastogenesis through the HIF-1α/BNIP3 signaling pathway.

Zhao Y, Chen G, Zhang W, Xu N, Zhu JY, Jia J, Sun ZJ, Wang YN, Zhao YF.

J Cell Physiol. 2012 Feb;227(2):639-48. doi: 10.1002/jcp.22768.


p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death.

Feng X, Liu X, Zhang W, Xiao W.

EMBO J. 2011 Jul 26;30(16):3397-415. doi: 10.1038/emboj.2011.248.


Upregulation of BNIP3 by 5-aza-2'-deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.

Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K.

J Gastroenterol. 2005 May;40(5):504-10.

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