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Items: 1 to 20 of 107

1.

Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.

Cottrell GS, Amadesi S, Pikios S, Camerer E, Willardsen JA, Murphy BR, Caughey GH, Wolters PJ, Coughlin SR, Peterson A, Knecht W, Pothoulakis C, Bunnett NW, Grady EF.

Gastroenterology. 2007 Jun;132(7):2422-37. Epub 2007 Apr 13.

2.

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia.

Knecht W, Cottrell GS, Amadesi S, Mohlin J, Skåregärde A, Gedda K, Peterson A, Chapman K, Hollenberg MD, Vergnolle N, Bunnett NW.

J Biol Chem. 2007 Sep 7;282(36):26089-100. Epub 2007 Jul 10.

3.

Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.

Kirkwood KS, Bunnett NW, Maa J, Castagliolo I, Liu B, Gerard N, Zacks J, Pothoulakis C, Grady EF.

Am J Physiol Gastrointest Liver Physiol. 2001 Aug;281(2):G544-51.

4.

Adenosine deaminase inhibition prevents Clostridium difficile toxin A-induced enteritis in mice.

de Araújo Junqueira AF, Dias AA, Vale ML, Spilborghs GM, Bossa AS, Lima BB, Carvalho AF, Guerrant RL, Ribeiro RA, Brito GA.

Infect Immun. 2011 Feb;79(2):653-62. doi: 10.1128/IAI.01159-10. Epub 2010 Nov 29.

5.

Local injection of dsRNA targeting calcitonin receptor-like receptor (CLR) ameliorates Clostridium difficile toxin A-induced ileitis.

Bhargava A, Clifton MS, Mhaske P, Liao M, Pothoulakis C, Leeman SE, Grady EF.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):731-6. doi: 10.1073/pnas.1219733110. Epub 2012 Dec 24. Erratum in: Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3651. Mhsake, Pallavi [corrected to Mhaske, Pallavi].

6.

Inflammation and apoptosis in Clostridium difficile enteritis is mediated by PGE2 up-regulation of Fas ligand.

Kim H, Rhee SH, Pothoulakis C, Lamont JT.

Gastroenterology. 2007 Sep;133(3):875-86. Epub 2007 Jul 3.

PMID:
17854595
7.

The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice.

Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW.

Gut. 2013 Sep;62(9):1295-305. doi: 10.1136/gutjnl-2012-302180. Epub 2012 Jul 3.

8.

Direct evidence of mast cell involvement in Clostridium difficile toxin A-induced enteritis in mice.

Wershil BK, Castagliuolo I, Pothoulakis C.

Gastroenterology. 1998 May;114(5):956-64.

PMID:
9558284
9.

Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis.

Cavalcante IC, Castro MV, Barreto AR, Sullivan GW, Vale M, Almeida PR, Linden J, Rieger JM, Cunha FQ, Guerrant RL, Ribeiro RA, Brito GA.

Infect Immun. 2006 May;74(5):2606-12.

10.

Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice.

Morteau O, Castagliuolo I, Mykoniatis A, Zacks J, Wlk M, Lu B, Pothoulakis C, Gerard NP, Gerard C.

Gastroenterology. 2002 Mar;122(3):725-33.

PMID:
11875005
11.

Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK.

Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, LaMont JT.

J Biol Chem. 2005 Jun 3;280(22):21237-45. Epub 2005 Mar 14.

12.

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2.

Cenac N, Coelho AM, Nguyen C, Compton S, Andrade-Gordon P, MacNaughton WK, Wallace JL, Hollenberg MD, Bunnett NW, Garcia-Villar R, Bueno L, Vergnolle N.

Am J Pathol. 2002 Nov;161(5):1903-15.

13.

Protease-activated receptor 2 in the intestinal inflammatory response induced by Clostridium difficile toxin A.

Kelly CP.

Gastroenterology. 2007 Jun;132(7):2599-601. No abstract available.

PMID:
17570231
14.

Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats.

Mantyh CR, McVey DC, Vigna SR.

Neurosci Lett. 2000 Oct 6;292(2):95-8.

PMID:
10998557
15.

Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats.

Castagliuolo I, Keates AC, Qiu B, Kelly CP, Nikulasson S, Leeman SE, Pothoulakis C.

Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4788-93.

16.

Serine proteases mediate inflammatory pain in acute pancreatitis.

Ceppa EP, Lyo V, Grady EF, Knecht W, Grahn S, Peterson A, Bunnett NW, Kirkwood KS, Cattaruzza F.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G1033-42. doi: 10.1152/ajpgi.00305.2010. Epub 2011 Mar 24.

17.

Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.

Gobbetti T, Cenac N, Motta JP, Rolland C, Martin L, Andrade-Gordon P, Steinhoff M, Barocelli E, Vergnolle N.

Am J Pathol. 2012 Jan;180(1):141-52. doi: 10.1016/j.ajpath.2011.09.031. Epub 2011 Nov 7.

PMID:
22067907
18.

Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice.

Kokkotou E, Espinoza DO, Torres D, Karagiannides I, Kosteletos S, Savidge T, O'Brien M, Pothoulakis C.

Gut. 2009 Jan;58(1):34-40. doi: 10.1136/gut.2008.155341. Epub 2008 Sep 29.

19.

Ketotifen inhibits Clostridium difficile toxin A-induced enteritis in rat ileum.

Pothoulakis C, Karmeli F, Kelly CP, Eliakim R, Joshi MA, O'Keane CJ, Castagliuolo I, LaMont JT, Rachmilewitz D.

Gastroenterology. 1993 Sep;105(3):701-7.

PMID:
8395445
20.

Essential involvement of IFN-gamma in Clostridium difficile toxin A-induced enteritis.

Ishida Y, Maegawa T, Kondo T, Kimura A, Iwakura Y, Nakamura S, Mukaida N.

J Immunol. 2004 Mar 1;172(5):3018-25.

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