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Werner syndrome protein interacts functionally with translesion DNA polymerases.

Kamath-Loeb AS, Lan L, Nakajima S, Yasui A, Loeb LA.

Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10394-9. Epub 2007 Jun 11.


WRN participates in translesion synthesis pathway through interaction with NBS1.

Kobayashi J, Okui M, Asaithamby A, Burma S, Chen BP, Tanimoto K, Matsuura S, Komatsu K, Chen DJ.

Mech Ageing Dev. 2010 Jun;131(6):436-44. doi: 10.1016/j.mad.2010.06.005. Epub 2010 Jun 17.


Functional interaction between the Werner Syndrome protein and DNA polymerase delta.

Kamath-Loeb AS, Johansson E, Burgers PM, Loeb LA.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4603-8.


The Werner syndrome protein binds replication fork and holliday junction DNAs as an oligomer.

Compton SA, Tolun G, Kamath-Loeb AS, Loeb LA, Griffith JD.

J Biol Chem. 2008 Sep 5;283(36):24478-83. doi: 10.1074/jbc.M803370200. Epub 2008 Jul 2.


The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA.

Phillips LG, Sale JE.

DNA Repair (Amst). 2010 Oct 5;9(10):1064-72. doi: 10.1016/j.dnarep.2010.07.006. Epub 2010 Aug 5.


The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.

Liu FJ, Barchowsky A, Opresko PL.

Toxicol Sci. 2009 Aug;110(2):307-18. doi: 10.1093/toxsci/kfp104. Epub 2009 Jun 1.


The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa.

Maddukuri L, Ketkar A, Eddy S, Zafar MK, Eoff RL.

Nucleic Acids Res. 2014 Oct 29;42(19):12027-40. doi: 10.1093/nar/gku913. Epub 2014 Oct 7.


Molecular cooperation between the Werner syndrome protein and replication protein A in relation to replication fork blockage.

Machwe A, Lozada E, Wold MS, Li GM, Orren DK.

J Biol Chem. 2011 Feb 4;286(5):3497-508. doi: 10.1074/jbc.M110.105411. Epub 2010 Nov 24.


WRN interacts physically and functionally with the recombination mediator protein RAD52.

Baynton K, Otterlei M, Bjørås M, von Kobbe C, Bohr VA, Seeberg E.

J Biol Chem. 2003 Sep 19;278(38):36476-86. Epub 2003 May 15.


The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.

Sidorova JM, Li N, Folch A, Monnat RJ Jr.

Cell Cycle. 2008 Mar 15;7(6):796-807. Epub 2008 Jan 4.


Nuclear DNA helicase II (RNA helicase A) interacts with Werner syndrome helicase and stimulates its exonuclease activity.

Friedemann J, Grosse F, Zhang S.

J Biol Chem. 2005 Sep 2;280(35):31303-13. Epub 2005 Jul 1.


The RAD9-RAD1-HUS1 (9.1.1) complex interacts with WRN and is crucial to regulate its response to replication fork stalling.

Pichierri P, Nicolai S, Cignolo L, Bignami M, Franchitto A.

Oncogene. 2012 Jun 7;31(23):2809-23. doi: 10.1038/onc.2011.468. Epub 2011 Oct 17.


The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: implications for WRN function.

Blank A, Bobola MS, Gold B, Varadarajan S, D Kolstoe D, Meade EH, Rabinovitch PS, Loeb LA, Silber JR.

DNA Repair (Amst). 2004 Jun 3;3(6):629-38.


The Werner syndrome protein is required for recruitment of chromatin assembly factor 1 following DNA damage.

Jiao R, Harrigan JA, Shevelev I, Dietschy T, Selak N, Indig FE, Piotrowski J, Janscak P, Bohr VA, Stagljar I.

Oncogene. 2007 May 31;26(26):3811-22. Epub 2006 Dec 18.


The Werner syndrome exonuclease facilitates DNA degradation and high fidelity DNA polymerization by human DNA polymerase δ.

Kamath-Loeb AS, Shen JC, Schmitt MW, Loeb LA.

J Biol Chem. 2012 Apr 6;287(15):12480-90. doi: 10.1074/jbc.M111.332577. Epub 2012 Feb 17.


Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.

von Kobbe C, Harrigan JA, Schreiber V, Stiegler P, Piotrowski J, Dawut L, Bohr VA.

Nucleic Acids Res. 2004 Aug 3;32(13):4003-14. Print 2004.


Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation.

Karmakar P, Piotrowski J, Brosh RM Jr, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA, Bohr VA.

J Biol Chem. 2002 May 24;277(21):18291-302. Epub 2002 Mar 11.


Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.

Franchitto A, Pirzio LM, Prosperi E, Sapora O, Bignami M, Pichierri P.

J Cell Biol. 2008 Oct 20;183(2):241-52. doi: 10.1083/jcb.200803173. Epub 2008 Oct 13.

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