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Items: 1 to 20 of 113

1.

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araújo EP, Vassallo J, Curi R, Velloso LA, Saad MJ.

Diabetes. 2007 Aug;56(8):1986-98. Epub 2007 May 22. Retraction in: Diabetes. 2016 Apr;65(4):1126-7.

2.

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet.

Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, Knauf C, Peiretti F, Verdier M, Juhan-Vague I, Tanti JF, Burcelin R, Alessi MC.

Diabetologia. 2007 Jun;50(6):1267-76. Epub 2007 Apr 11.

PMID:
17426960
3.

Physical exercise reduces circulating lipopolysaccharide and TLR4 activation and improves insulin signaling in tissues of DIO rats.

Oliveira AG, Carvalho BM, Tobar N, Ropelle ER, Pauli JR, Bagarolli RA, Guadagnini D, Carvalheira JB, Saad MJ.

Diabetes. 2011 Mar;60(3):784-96. doi: 10.2337/db09-1907. Epub 2011 Jan 31. Retraction in: Diabetes. 2016 Apr;65(4):1124-5.

4.

Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes.

Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J.

Mol Endocrinol. 2004 Aug;18(8):2024-34. Epub 2004 May 13.

PMID:
15143153
5.

A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats.

Liu HQ, Qiu Y, Mu Y, Zhang XJ, Liu L, Hou XH, Zhang L, Xu XN, Ji AL, Cao R, Yang RH, Wang F.

Nutr Res. 2013 Oct;33(10):849-58. doi: 10.1016/j.nutres.2013.07.004. Epub 2013 Aug 9.

PMID:
24074743
6.

Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW.

Circ Res. 2007 Jun 8;100(11):1589-96. Epub 2007 May 3.

7.

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME.

Obesity (Silver Spring). 2008 Jun;16(6):1248-55. doi: 10.1038/oby.2008.210. Epub 2008 Apr 10.

8.

TLR4 links innate immunity and fatty acid-induced insulin resistance.

Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS.

J Clin Invest. 2006 Nov;116(11):3015-25. Epub 2006 Oct 19.

9.

EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.

Prada PO, Ropelle ER, Mourão RH, de Souza CT, Pauli JR, Cintra DE, Schenka A, Rocco SA, Rittner R, Franchini KG, Vassallo J, Velloso LA, Carvalheira JB, Saad MJ.

Diabetes. 2009 Dec;58(12):2910-9. doi: 10.2337/db08-0506. Epub 2009 Aug 20. Retraction in: Diabetes. 2017 Apr 27;:. Diabetes. 2017 Jul;66(7):2059.

10.

The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway.

Miao X, Wang Y, Wang W, Lv X, Wang M, Yin H.

Mol Cell Endocrinol. 2015 Mar 5;403:1-9. doi: 10.1016/j.mce.2014.12.017. Epub 2015 Jan 14.

PMID:
25596549
11.

Western diet modulates insulin signaling, c-Jun N-terminal kinase activity, and insulin receptor substrate-1ser307 phosphorylation in a tissue-specific fashion.

Prada PO, Zecchin HG, Gasparetti AL, Torsoni MA, Ueno M, Hirata AE, Corezola do Amaral ME, Höer NF, Boschero AC, Saad MJ.

Endocrinology. 2005 Mar;146(3):1576-87. Epub 2004 Dec 9.

PMID:
15591151
12.
13.

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance.

Perfield JW 2nd, Lee Y, Shulman GI, Samuel VT, Jurczak MJ, Chang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS.

Diabetes. 2011 Apr;60(4):1168-76. doi: 10.2337/db10-0715. Epub 2011 Feb 23.

14.

You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice.

Wang Y, Ziogas DC, Biddinger S, Kokkotou E.

Gut. 2010 Dec;59(12):1625-34. doi: 10.1136/gut.2010.210526. Epub 2010 Oct 21.

15.

Pharmacological characterization of a small molecule inhibitor of c-Jun kinase.

Cho H, Black SC, Looper D, Shi M, Kelly-Sullivan D, Timofeevski S, Siegel K, Yu XH, McDonnell SR, Chen P, Yie J, Ogilvie KM, Fraser J, Briscoe CP.

Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1142-51. doi: 10.1152/ajpendo.90298.2008. Epub 2008 Aug 26.

16.

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.

Milanski M, Degasperi G, Coope A, Morari J, Denis R, Cintra DE, Tsukumo DM, Anhe G, Amaral ME, Takahashi HK, Curi R, Oliveira HC, Carvalheira JB, Bordin S, Saad MJ, Velloso LA.

J Neurosci. 2009 Jan 14;29(2):359-70. doi: 10.1523/JNEUROSCI.2760-08.2009.

17.

Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice.

Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, Bandyopadhyay G, Verma IM, Olefsky JM.

Cell Metab. 2009 Nov;10(5):419-29. doi: 10.1016/j.cmet.2009.09.006.

18.

Low salt intake modulates insulin signaling, JNK activity and IRS-1ser307 phosphorylation in rat tissues.

Prada PO, Coelho MS, Zecchin HG, Dolnikoff MS, Gasparetti AL, Furukawa LN, Saad MJ, Heimann JC.

J Endocrinol. 2005 Jun;185(3):429-37.

19.

Loss of regulator of G protein signaling 5 exacerbates obesity, hepatic steatosis, inflammation and insulin resistance.

Deng W, Wang X, Xiao J, Chen K, Zhou H, Shen D, Li H, Tang Q.

PLoS One. 2012;7(1):e30256. doi: 10.1371/journal.pone.0030256. Epub 2012 Jan 17.

20.

Insight into the impact of dietary saturated fat on tissue-specific cellular processes underlying obesity-related diseases.

Enos RT, Velázquez KT, Murphy EA.

J Nutr Biochem. 2014 Jun;25(6):600-12. doi: 10.1016/j.jnutbio.2014.01.011. Epub 2014 Mar 12.

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