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Items: 1 to 20 of 102

1.

Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.

Chen Q, Espey MG, Sun AY, Lee JH, Krishna MC, Shacter E, Choyke PL, Pooput C, Kirk KL, Buettner GR, Levine M.

Proc Natl Acad Sci U S A. 2007 May 22;104(21):8749-54. Epub 2007 May 14.

2.

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects.

Verrax J, Calderon PB.

Free Radic Biol Med. 2009 Jul 1;47(1):32-40. doi: 10.1016/j.freeradbiomed.2009.02.016. Epub 2009 Feb 28.

PMID:
19254759
3.

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.

Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13604-9. Epub 2005 Sep 12.

4.

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice.

Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, Khosh DB, Drisko J, Levine M.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11105-9. doi: 10.1073/pnas.0804226105. Epub 2008 Aug 4.

5.

Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries.

Levine M, Padayatty SJ, Espey MG.

Adv Nutr. 2011 Mar;2(2):78-88. doi: 10.3945/an.110.000109. Epub 2011 Mar 10. Review.

6.

Augmentation of respiratory tract lining fluid ascorbate concentrations through supplementation with vitamin C.

Behndig AF, Blomberg A, Helleday R, Kelly FJ, Mudway IS.

Inhal Toxicol. 2009 Feb;21(3):250-8. doi: 10.1080/08958370802474736 .

PMID:
19009458
7.

Cytotoxic effects of high concentrations of sodium ascorbate on human myeloid cell lines.

Mastrangelo D, Massai L, Lo Coco F, Noguera NI, Borgia L, Fioritoni G, Berardi A, Iacone A, Muscettola M, Pelosi E, Castelli G, Testa U, Di Pisa F, Grasso G.

Ann Hematol. 2015 Nov;94(11):1807-16. doi: 10.1007/s00277-015-2464-2. Epub 2015 Aug 12.

PMID:
26264692
8.

Ascorbate potentiates DNA damage by 1-methyl-1-nitrosourea in vivo and generates DNA strand breaks in vitro.

Woolley PV, Kumar S, Fitzgerald P, Simpson RT.

Carcinogenesis. 1987 Nov;8(11):1657-62.

PMID:
2822277
10.

Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.

Kagan VE, Kuzmenko AI, Shvedova AA, Kisin ER, Li R, Martin I, Quinn PJ, Tyurin VA, Tyurina YY, Yalowich JC.

Biochim Biophys Acta. 2003 Mar 17;1620(1-3):72-84.

PMID:
12595076
11.

H(2)O(2)-mediated cytotoxicity of pharmacologic ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin.

Deubzer B, Mayer F, Kuçi Z, Niewisch M, Merkel G, Handgretinger R, Bruchelt G.

Cell Physiol Biochem. 2010;25(6):767-74. doi: 10.1159/000315098. Epub 2010 May 18.

12.
14.

Exercise training generates ascorbate free radical in rat heart.

Somani SM, Arroyo CM.

Indian J Physiol Pharmacol. 1995 Oct;39(4):323-9.

PMID:
8582743
15.

Sodium-ascorbate cotransport controls intracellular ascorbate concentration in primary astrocyte cultures expressing the SVCT2 transporter.

Korcok J, Yan R, Siushansian R, Dixon SJ, Wilson JX.

Brain Res. 2000 Oct 27;881(2):144-51.

PMID:
11036152
16.

Oxidative stress in lungs of mice infected with influenza A virus.

Buffinton GD, Christen S, Peterhans E, Stocker R.

Free Radic Res Commun. 1992;16(2):99-110.

17.

[An in vitro study on the pharmacological ascorbate treatment of influenza virus].

Cheng LL, Liu YY, Li B, Li SY, Ran PX.

Zhonghua Jie He He Hu Xi Za Zhi. 2012 Jul;35(7):520-3. Chinese.

PMID:
22931805
18.

Ascorbate/menadione-induced oxidative stress kills cancer cells that express normal or mutated forms of the oncogenic protein Bcr-Abl. An in vitro and in vivo mechanistic study.

Beck R, Pedrosa RC, Dejeans N, Glorieux C, Levêque P, Gallez B, Taper H, Eeckhoudt S, Knoops L, Calderon PB, Verrax J.

Invest New Drugs. 2011 Oct;29(5):891-900. doi: 10.1007/s10637-010-9441-3. Epub 2010 May 8.

PMID:
20454833
19.

Production of hydrogen peroxide in cancerous tissue by intravenous administration of sodium 5,6-benzylidene-L-ascorbate.

Asano K, Satoh K, Hosaka M, Arakawa H, Inagaki M, Hisamitsu T, Maeda M, Kochi M, Sakagami H.

Anticancer Res. 1999 Jan-Feb;19(1A):229-36.

PMID:
10226547
20.

In vivo determination of extracellular brain ascorbate.

Miele M, Fillenz M.

J Neurosci Methods. 1996 Dec;70(1):15-9.

PMID:
8982976
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