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Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity.

Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW.

Circ Res. 2007 Jun 8;100(11):1589-96. Epub 2007 May 3.


Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

Rizzo NO, Maloney E, Pham M, Luttrell I, Wessells H, Tateya S, Daum G, Handa P, Schwartz MW, Kim F.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):758-65. doi: 10.1161/ATVBAHA.109.199893. Epub 2010 Jan 21.


Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation.

Maloney E, Sweet IR, Hockenbery DM, Pham M, Rizzo NO, Tateya S, Handa P, Schwartz MW, Kim F.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1370-5. doi: 10.1161/ATVBAHA.109.188813. Epub 2009 Jun 18.


Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

Kim F, Pham M, Maloney E, Rizzo NO, Morton GJ, Wisse BE, Kirk EA, Chait A, Schwartz MW.

Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):1982-8. doi: 10.1161/ATVBAHA.108.169722. Epub 2008 Sep 4.


TLR4 is required for the obesity-induced pancreatic beta cell dysfunction.

Li J, Chen L, Zhang Y, Zhang WJ, Xu W, Qin Y, Xu J, Zou D.

Acta Biochim Biophys Sin (Shanghai). 2013 Dec;45(12):1030-8. doi: 10.1093/abbs/gmt092. Epub 2013 Aug 28. Erratum in: Acta Biochim Biophys Sin (Shanghai). 2014 Feb;46(2):167.


Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure.

Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED.

Circ Res. 2009 May 8;104(9):1085-94. doi: 10.1161/CIRCRESAHA.108.189316. Epub 2009 Apr 2.


Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects.

Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N.

Diabetes. 2008 Oct;57(10):2595-602. doi: 10.2337/db08-0038. Epub 2008 Jul 15.


The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway.

Miao X, Wang Y, Wang W, Lv X, Wang M, Yin H.

Mol Cell Endocrinol. 2015 Mar 5;403:1-9. doi: 10.1016/j.mce.2014.12.017. Epub 2015 Jan 14.


Vasodilator-stimulated phosphoprotein protects against vascular inflammation and insulin resistance.

Cheng AM, Rizzo-DeLeon N, Wilson CL, Lee WJ, Tateya S, Clowes AW, Schwartz MW, Kim F.

Am J Physiol Endocrinol Metab. 2014 Oct 1;307(7):E571-9. doi: 10.1152/ajpendo.00303.2014. Epub 2014 Aug 12.


[Effect of Berberine on the Insulin Resistance and TLR4/IKKbeta/NF-kappaB Signaling Pathways in Skeletal Muscle of Obese Rats with Insulin Resistance].

Zhang DS, Bai XH, Yao YJ, Mu DZ, Chen J.

Sichuan Da Xue Xue Bao Yi Xue Ban. 2015 Nov;46(6):827-31. Chinese.


Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.

Kim F, Tysseling KA, Rice J, Pham M, Haji L, Gallis BM, Baas AS, Paramsothy P, Giachelli CM, Corson MA, Raines EW.

Arterioscler Thromb Vasc Biol. 2005 May;25(5):989-94. Epub 2005 Feb 24.


A high ratio of dietary n-3/n-6 polyunsaturated fatty acids improves obesity-linked inflammation and insulin resistance through suppressing activation of TLR4 in SD rats.

Liu HQ, Qiu Y, Mu Y, Zhang XJ, Liu L, Hou XH, Zhang L, Xu XN, Ji AL, Cao R, Yang RH, Wang F.

Nutr Res. 2013 Oct;33(10):849-58. doi: 10.1016/j.nutres.2013.07.004. Epub 2013 Aug 9.


Hepatocyte Toll-like receptor 4 regulates obesity-induced inflammation and insulin resistance.

Jia L, Vianna CR, Fukuda M, Berglund ED, Liu C, Tao C, Sun K, Liu T, Harper MJ, Lee CE, Lee S, Scherer PE, Elmquist JK.

Nat Commun. 2014 May 12;5:3878. doi: 10.1038/ncomms4878.


Innate immune pathway links obesity to insulin resistance.

Shah PK.

Circ Res. 2007 Jun 8;100(11):1531-3. No abstract available.


TLR4-mediated inflammation promotes foam cell formation of vascular smooth muscle cell by upregulating ACAT1 expression.

Yin YW, Liao SQ, Zhang MJ, Liu Y, Li BH, Zhou Y, Chen L, Gao CY, Li JC, Zhang LL.

Cell Death Dis. 2014 Dec 18;5:e1574. doi: 10.1038/cddis.2014.535. Erratum in: Cell Death Dis. 2015;6:1659.


Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Ara├║jo EP, Vassallo J, Curi R, Velloso LA, Saad MJ.

Diabetes. 2007 Aug;56(8):1986-98. Epub 2007 May 22. Retraction in: Diabetes. 2016 Apr;65(4):1126-7.


Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism.

Sindhu S, Al-Roub A, Koshy M, Thomas R, Ahmad R.

Cell Physiol Biochem. 2016;39(3):889-900. doi: 10.1159/000447798. Epub 2016 Aug 9.


Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance.

Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS, Bhattacharya S.

Nat Med. 2012 Aug;18(8):1279-85. doi: 10.1038/nm.2851. Epub 2012 Jul 29.


High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse.

Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NM, Magness S, Jobin C, Lund PK.

PLoS One. 2010 Aug 16;5(8):e12191. doi: 10.1371/journal.pone.0012191.


Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil.

Zhao M, Zang B, Cheng M, Ma Y, Yang Y, Yang N.

PLoS One. 2013 Nov 6;8(11):e78620. doi: 10.1371/journal.pone.0078620. eCollection 2013.

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