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The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex.

Stracker TH, Morales M, Couto SS, Hussein H, Petrini JH.

Nature. 2007 May 10;447(7141):218-21. Epub 2007 Apr 11.


Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS.

Mol Cancer Res. 2003 Jul;1(9):674-81.


The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.

Genes Dev. 2005 Dec 15;19(24):3043-54.


A murine model of Nijmegen breakage syndrome.

Williams BR, Mirzoeva OK, Morgan WF, Lin J, Dunnick W, Petrini JH.

Curr Biol. 2002 Apr 16;12(8):648-53.


Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A.

Nat Cell Biol. 2005 Jul;7(7):675-85. Epub 2005 Jun 19.


Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.

Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT.

J Biol Chem. 2013 May 3;288(18):12840-51. doi: 10.1074/jbc.M113.460378. Epub 2013 Mar 22.


Multiple roles for MRE11 at uncapped telomeres.

Deng Y, Guo X, Ferguson DO, Chang S.

Nature. 2009 Aug 13;460(7257):914-8. doi: 10.1038/nature08196. Epub 2009 Jul 26.


Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, Russell HR, Petrini JH, McKinnon PJ.

Genes Dev. 2009 Jan 15;23(2):171-80. doi: 10.1101/gad.1746609.


ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.

You Z, Chahwan C, Bailis J, Hunter T, Russell P.

Mol Cell Biol. 2005 Jul;25(13):5363-79.


Autophosphorylation and ATM activation: additional sites add to the complexity.

Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF.

J Biol Chem. 2011 Mar 18;286(11):9107-19. doi: 10.1074/jbc.M110.204065. Epub 2010 Dec 13.


SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J.

Genes Dev. 2002 Mar 1;16(5):571-82.


Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis.

Taylor AM, Groom A, Byrd PJ.

DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1219-25. Review.


Active role for nibrin in the kinetics of atm activation.

Cerosaletti K, Wright J, Concannon P.

Mol Cell Biol. 2006 Mar;26(5):1691-9.


Cleavage of the BRCT tandem domains of nibrin by the 657del5 mutation affects the DNA damage response less than the Arg215Trp mutation.

Mendez G, Cilli D, Berardinelli F, Viganotti M, Ascenzi P, Tanzarella C, Antoccia A, di Masi A.

IUBMB Life. 2012 Oct;64(10):853-61. doi: 10.1002/iub.1077. Epub 2012 Sep 3.


Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression.

Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y.

Mol Cell Biol. 2005 Jan;25(2):661-70.


NBS1 prevents chromatid-type aberrations through ATM-dependent interactions with SMC1.

Antoccia A, Sakamoto S, Matsuura S, Tauchi H, Komatsu K.

Radiat Res. 2008 Sep;170(3):345-52. doi: 10.1667/RR1357.1.


Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.

Cerosaletti K, Concannon P.

J Biol Chem. 2004 Sep 10;279(37):38813-9. Epub 2004 Jul 1.


Chk2 activation dependence on Nbs1 after DNA damage.

Buscemi G, Savio C, Zannini L, Miccichè F, Masnada D, Nakanishi M, Tauchi H, Komatsu K, Mizutani S, Khanna K, Chen P, Concannon P, Chessa L, Delia D.

Mol Cell Biol. 2001 Aug;21(15):5214-22.


Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability.

Stracker TH, Williams BR, Deriano L, Theunissen JW, Adelman CA, Roth DB, Petrini JH.

Mol Cell Biol. 2009 Jan;29(2):503-14. doi: 10.1128/MCB.01354-08. Epub 2008 Nov 17.

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