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Items: 1 to 20 of 97


Mania-like behavior induced by disruption of CLOCK.

Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6406-11. Epub 2007 Mar 22.


Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior.

Mukherjee S, Coque L, Cao JL, Kumar J, Chakravarty S, Asaithamby A, Graham A, Gordon E, Enwright JF 3rd, DiLeone RJ, Birnbaum SG, Cooper DC, McClung CA.

Biol Psychiatry. 2010 Sep 15;68(6):503-11. doi: 10.1016/j.biopsych.2010.04.031. Epub 2010 Jun 29.


What can a clock mutation in mice tell us about bipolar disorder?

Coyle JT.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6097-8. Epub 2007 Apr 2. No abstract available.


Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.

Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA.

Neuropsychopharmacology. 2011 Jun;36(7):1478-88. doi: 10.1038/npp.2011.33. Epub 2011 Mar 23.


The Clock gene and bipolar disorder. Commentary.

Miller MC.

Harv Ment Health Lett. 2007 Aug;24(2):8. No abstract available.


Genetic and clinical factors predict lithium's effects on PER2 gene expression rhythms in cells from bipolar disorder patients.

McCarthy MJ, Wei H, Marnoy Z, Darvish RM, McPhie DL, Cohen BM, Welsh DK.

Transl Psychiatry. 2013 Oct 22;3:e318. doi: 10.1038/tp.2013.90.


Role for the Clock gene in bipolar disorder.

McClung CA.

Cold Spring Harb Symp Quant Biol. 2007;72:637-44. doi: 10.1101/sqb.2007.72.031. Review.


Identification of a glycogen synthase kinase-3β inhibitor that attenuates hyperactivity in CLOCK mutant mice.

Kozikowski AP, Gunosewoyo H, Guo S, Gaisina IN, Walter RL, Ketcherside A, McClung CA, Mesecar AD, Caldarone B.

ChemMedChem. 2011 Sep 5;6(9):1593-602. doi: 10.1002/cmdc.201100188. Epub 2011 Jul 5.


Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment.

Schnell A, Sandrelli F, Ranc V, Ripperger JA, Brai E, Alberi L, Rainer G, Albrecht U.

Chronobiol Int. 2015;32(8):1075-89. doi: 10.3109/07420528.2015.1062024. Epub 2015 Aug 28.


Regulation of dopaminergic transmission and cocaine reward by the Clock gene.

McClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ.

Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9377-81. Epub 2005 Jun 20.


Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania.

Dzirasa K, Coque L, Sidor MM, Kumar S, Dancy EA, Takahashi JS, McClung CA, Nicolelis MA.

J Neurosci. 2010 Dec 1;30(48):16314-23. doi: 10.1523/JNEUROSCI.4289-10.2010.


Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.

Sidor MM, Spencer SM, Dzirasa K, Parekh PK, Tye KM, Warden MR, Arey RN, Enwright JF 3rd, Jacobsen JP, Kumar S, Remillard EM, Caron MG, Deisseroth K, McClung CA.

Mol Psychiatry. 2015 Nov;20(11):1406-19. doi: 10.1038/mp.2014.167. Epub 2015 Jan 6. Erratum in: Mol Psychiatry. 2015 Nov;20(11):1479-80.


An important role for cholecystokinin, a CLOCK target gene, in the development and treatment of manic-like behaviors.

Arey RN, Enwright JF 3rd, Spencer SM, Falcon E, Ozburn AR, Ghose S, Tamminga C, McClung CA.

Mol Psychiatry. 2014 Mar;19(3):342-50. doi: 10.1038/mp.2013.12. Epub 2013 Feb 12. Erratum in: Mol Psychiatry. 2014 Mar;19(3):400.


Circadian rhythms and clock genes in psychotic disorders.

Lamont EW, Coutu DL, Cermakian N, Boivin DB.

Isr J Psychiatry Relat Sci. 2010;47(1):27-35. Review.


Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression.

Benedetti F, Dallaspezia S, Fulgosi MC, Lorenzi C, Serretti A, Barbini B, Colombo C, Smeraldi E.

Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):631-5.


A single nucleotide polymorphism in glycogen synthase kinase 3-beta promoter gene influences onset of illness in patients affected by bipolar disorder.

Benedetti F, Bernasconi A, Lorenzi C, Pontiggia A, Serretti A, Colombo C, Smeraldi E.

Neurosci Lett. 2004 Jan 23;355(1-2):37-40.


Glycogen synthase kinase 3beta as a likely target for the action of lithium on circadian clocks.

Padiath QS, Paranjpe D, Jain S, Sharma VK.

Chronobiol Int. 2004 Jan;21(1):43-55.


Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms.

McCarthy MJ, Le Roux MJ, Wei H, Beesley S, Kelsoe JR, Welsh DK.

Neuropharmacology. 2016 Feb;101:439-48. doi: 10.1016/j.neuropharm.2015.10.017. Epub 2015 Oct 22.


Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice.

Kolker DE, Vitaterna MH, Fruechte EM, Takahashi JS, Turek FW.

Neurobiol Aging. 2004 Apr;25(4):517-23.


The circadian Clock mutation increases exploratory activity and escape-seeking behavior.

Easton A, Arbuzova J, Turek FW.

Genes Brain Behav. 2003 Feb;2(1):11-9.

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