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Items: 1 to 20 of 164

1.

Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.

Zhang WJ, Wei H, Hagen T, Frei B.

Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4077-82. Epub 2007 Feb 27.

2.

α-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism.

Jiang S, Zhu W, Li C, Zhang X, Lu T, Ding Z, Cao K, Liu L.

Int Immunopharmacol. 2013 May;16(1):100-7. doi: 10.1016/j.intimp.2013.03.024. Epub 2013 Apr 3.

PMID:
23562296
3.

Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells.

Koriyama Y, Nakayama Y, Matsugo S, Sugitani K, Ogai K, Takadera T, Kato S.

Neurosci Res. 2013 Sep-Oct;77(1-2):87-96. doi: 10.1016/j.neures.2013.07.001. Epub 2013 Jul 24.

PMID:
23892131
4.

Alpha-lipoic acid activates eNOS through activation of PI3-kinase/Akt signaling pathway.

Ying Z, Xie X, Chen M, Yi K, Rajagopalan S.

Vascul Pharmacol. 2015 Jan;64:28-35. doi: 10.1016/j.vph.2014.11.004. Epub 2014 Nov 22.

5.
6.

(R)-(+)-α-lipoic acid protected NG108-15 cells against H₂O₂-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines.

Kamarudin MN, Mohd Raflee NA, Hussein SS, Lo JY, Supriady H, Abdul Kadir H.

Drug Des Devel Ther. 2014 Oct 8;8:1765-80. doi: 10.2147/DDDT.S67980. eCollection 2014.

7.

Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-kappaB signaling pathway.

Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC.

Eur J Pharmacol. 2010 Sep 10;642(1-3):146-53. doi: 10.1016/j.ejphar.2010.05.012. Epub 2010 May 25.

PMID:
20519138
8.

Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK/AP-1 and IKK/NF-κB-induced inflammatory mediators production in RAW 264.7 cells.

Endale M, Park SC, Kim S, Kim SH, Yang Y, Cho JY, Rhee MH.

Immunobiology. 2013 Dec;218(12):1452-67. doi: 10.1016/j.imbio.2013.04.019. Epub 2013 May 9.

PMID:
23735482
9.

Isobutyrylshikonin inhibits lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in BV2 microglial cells by suppressing the PI3K/Akt-mediated nuclear transcription factor-κB pathway.

Jayasooriya RG, Lee KT, Kang CH, Dilshara MG, Lee HJ, Choi YH, Choi IW, Kim GY.

Nutr Res. 2014 Dec;34(12):1111-9. doi: 10.1016/j.nutres.2014.10.002. Epub 2014 Oct 7.

PMID:
25454762
10.

Evidence that α-lipoic acid inhibits NF-κB activation independent of its antioxidant function.

Ying Z, Kampfrath T, Sun Q, Parthasarathy S, Rajagopalan S.

Inflamm Res. 2011 Mar;60(3):219-25. doi: 10.1007/s00011-010-0256-7. Epub 2010 Oct 7.

PMID:
20927568
11.

A dopamine-alpha-lipoic acid hybridization compound and its acetylated form inhibit LPS-mediated inflammation.

Hwang JS, An JM, Cho H, Lee SH, Park JH, Han IO.

Eur J Pharmacol. 2015 Jan 5;746:41-9. doi: 10.1016/j.ejphar.2014.10.052. Epub 2014 Nov 6.

PMID:
25445046
12.

PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice.

Schabbauer G, Tencati M, Pedersen B, Pawlinski R, Mackman N.

Arterioscler Thromb Vasc Biol. 2004 Oct;24(10):1963-9. Epub 2004 Aug 19.

14.

C-type natriuretic peptide attenuates LPS-induced endothelial activation: involvement of p38, Akt, and NF-κB pathways.

Chen G, Zhao J, Yin Y, Wang B, Liu Q, Li P, Zhao L, Zhou H.

Amino Acids. 2014 Dec;46(12):2653-63. doi: 10.1007/s00726-014-1816-x. Epub 2014 Aug 6.

PMID:
25096521
15.

Insulin activation of the phosphatidylinositol 3-kinase/protein kinase B (Akt) pathway reduces lipopolysaccharide-induced inflammation in mice.

Kidd LB, Schabbauer GA, Luyendyk JP, Holscher TD, Tilley RE, Tencati M, Mackman N.

J Pharmacol Exp Ther. 2008 Jul;326(1):348-53. doi: 10.1124/jpet.108.138891. Epub 2008 Apr 29.

16.

Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.

Qi S, Xin Y, Guo Y, Diao Y, Kou X, Luo L, Yin Z.

Int Immunopharmacol. 2012 Jan;12(1):278-87. doi: 10.1016/j.intimp.2011.12.001. Epub 2011 Dec 20.

PMID:
22193240
17.

Hypoxia-induced mitogenic factor promotes vascular adhesion molecule-1 expression via the PI-3K/Akt-NF-kappaB signaling pathway.

Tong Q, Zheng L, Lin L, Li B, Wang D, Li D.

Am J Respir Cell Mol Biol. 2006 Oct;35(4):444-56. Epub 2006 May 18.

18.

Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism.

Wang X, Zhang X, Cheng Y, Li C, Zhang W, Liu L, Ding Z.

Neurotoxicology. 2010 Jan;31(1):101-12. doi: 10.1016/j.neuro.2009.10.010. Epub 2009 Oct 29.

PMID:
19879292
19.

Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.

Müller C, Dünschede F, Koch E, Vollmar AM, Kiemer AK.

Am J Physiol Gastrointest Liver Physiol. 2003 Oct;285(4):G769-78. Epub 2003 Jun 19.

20.

Desmethylanhydroicaritin inhibits NF-kappaB-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway.

Kim JH, Lee G, Cho YL, Kim CK, Han S, Lee H, Choi JS, Choe J, Won MH, Kwon YG, Ha KS, Kim YM.

Eur J Pharmacol. 2009 Jan 14;602(2-3):422-31. doi: 10.1016/j.ejphar.2008.10.062. Epub 2008 Nov 9.

PMID:
19027002

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