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Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response.

Rempel SA, Hawley RC, Gutiérrez JA, Mouzon E, Bobbitt KR, Lemke N, Schultz CR, Schultz LR, Golembieski W, Koblinski J, VanOsdol S, Miller CG.

Genes Immun. 2007 Apr;8(3):262-74. Epub 2007 Mar 8.


SPARC-null mice exhibit increased adiposity without significant differences in overall body weight.

Bradshaw AD, Graves DC, Motamed K, Sage EH.

Proc Natl Acad Sci U S A. 2003 May 13;100(10):6045-50. Epub 2003 Apr 29.


Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression.

Mansergh FC, Wells T, Elford C, Evans SL, Perry MJ, Evans MJ, Evans BA.

Physiol Genomics. 2007 Dec 19;32(1):64-73. Epub 2007 Sep 18.


The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses.

Piconese S, Costanza M, Tripodo C, Sangaletti S, Musio S, Pittoni P, Poliani PL, Burocchi A, Passafaro AL, Gorzanelli A, Vitali C, Chiodoni C, Barnaba V, Pedotti R, Colombo MP.

J Autoimmun. 2011 Dec;37(4):300-10. doi: 10.1016/j.jaut.2011.09.002. Epub 2011 Sep 29.


Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM.

Brekken RA, Puolakkainen P, Graves DC, Workman G, Lubkin SR, Sage EH.

J Clin Invest. 2003 Feb;111(4):487-95.


Enhanced angiogenesis characteristic of SPARC-null mice disappears with age.

Reed MJ, Bradshaw AD, Shaw M, Sadoun E, Han N, Ferara N, Funk S, Puolakkainen P, Sage EH.

J Cell Physiol. 2005 Sep;204(3):800-7.


Primary mesenchymal cells isolated from SPARC-null mice exhibit altered morphology and rates of proliferation.

Bradshaw AD, Francki A, Motamed K, Howe C, Sage EH.

Mol Biol Cell. 1999 May;10(5):1569-79.


Secreted protein acidic and rich in cysteine (SPARC) exacerbates colonic inflammatory symptoms in dextran sodium sulphate-induced murine colitis.

Ng YL, Klopcic B, Lloyd F, Forrest C, Greene W, Lawrance IC.

PLoS One. 2013 Oct 21;8(10):e77575. doi: 10.1371/journal.pone.0077575. eCollection 2013.


Loss of Sparc in p53-null Astrocytes Promotes Macrophage Activation and Phagocytosis Resulting in Decreased Tumor Size and Tumor Cell Survival.

Thomas SL, Schultz CR, Mouzon E, Golembieski WA, El Naili R, Radakrishnan A, Lemke N, Poisson LM, Gutiérrez JA, Cottingham S, Rempel SA.

Brain Pathol. 2015 Jul;25(4):391-400. doi: 10.1111/bpa.12161. Epub 2015 Apr 20.


Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis.

Strandjord TP, Madtes DK, Weiss DJ, Sage EH.

Am J Physiol. 1999 Sep;277(3 Pt 1):L628-35.


Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization.

Toba H, de Castro Brás LE, Baicu CF, Zile MR, Lindsey ML, Bradshaw AD.

Am J Physiol Cell Physiol. 2015 Jun 15;308(12):C972-82. doi: 10.1152/ajpcell.00402.2014. Epub 2015 Apr 15.


SPARC deficiency affects bone marrow stromal function, resulting in impaired B lymphopoiesis.

Luo Z, Zhou Y, Luo P, Zhao Q, Xiao N, Yu Y, Yan Q, Lu G, Cheng L.

J Leukoc Biol. 2014 Jul;96(1):73-82. doi: 10.1189/jlb.1A0713-415RR. Epub 2014 Mar 5.


Differences in gene expression profiles from asbestos-treated SPARC-null and wild-type mouse lungs.

Pershouse MA, Smartt AM, Schwanke C, Putnam EA.

Genomics. 2009 Aug;94(2):101-9. doi: 10.1016/j.ygeno.2009.04.009. Epub 2009 May 13.


Losartan slows pancreatic tumor progression and extends survival of SPARC-null mice by abrogating aberrant TGFβ activation.

Arnold SA, Rivera LB, Carbon JG, Toombs JE, Chang CL, Bradshaw AD, Brekken RA.

PLoS One. 2012;7(2):e31384. doi: 10.1371/journal.pone.0031384. Epub 2012 Feb 14.


Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials.

Puolakkainen P, Bradshaw AD, Kyriakides TR, Reed M, Brekken R, Wight T, Bornstein P, Ratner B, Sage EH.

Am J Pathol. 2003 Feb;162(2):627-35.


Gene expression changes during cataract progression in Sparc null mice: differential regulation of mouse globins in the lens.

Mansergh FC, Wride MA, Walker VE, Adams S, Hunter SM, Evans MJ.

Mol Vis. 2004 Jul 20;10:490-511.


The fate of self-reactive B cells depends primarily on the degree of antigen receptor engagement and availability of T cell help.

Fulcher DA, Lyons AB, Korn SL, Cook MC, Koleda C, Parish C, Fazekas de St Groth B, Basten A.

J Exp Med. 1996 May 1;183(5):2313-28.


SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery.

Seet LF, Su R, Barathi VA, Lee WS, Poh R, Heng YM, Manser E, Vithana EN, Aung T, Weaver M, Sage EH, Wong TT.

PLoS One. 2010 Feb 25;5(2):e9415. doi: 10.1371/journal.pone.0009415.


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