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Items: 1 to 20 of 120

1.

Effects of kava alkaloid, pipermethystine, and kavalactones on oxidative stress and cytochrome P450 in F-344 rats.

Lim ST, Dragull K, Tang CS, Bittenbender HC, Efird JT, Nerurkar PV.

Toxicol Sci. 2007 May;97(1):214-21. Epub 2007 Feb 27.

PMID:
17329236
2.

In vitro toxicity of kava alkaloid, pipermethystine, in HepG2 cells compared to kavalactones.

Nerurkar PV, Dragull K, Tang CS.

Toxicol Sci. 2004 May;79(1):106-11. Epub 2004 Jan 21.

PMID:
14737001
3.

High dose of commercial products of kava (Piper methysticum) markedly enhanced hepatic cytochrome P450 1A1 mRNA expression with liver enlargement in rats.

Yamazaki Y, Hashida H, Arita A, Hamaguchi K, Shimura F.

Food Chem Toxicol. 2008 Dec;46(12):3732-8. doi: 10.1016/j.fct.2008.09.052. Epub 2008 Sep 30.

PMID:
18930106
4.

Is the alkaloid pipermethystine connected with the claimed liver toxicity of Kava products?

Lechtenberg M, Quandt B, Schmidt M, Nahrstedt A.

Pharmazie. 2008 Jan;63(1):71-4.

PMID:
18271308
5.

Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract.

Guo L, Li Q, Xia Q, Dial S, Chan PC, Fu P.

Food Chem Toxicol. 2009 Feb;47(2):433-42. doi: 10.1016/j.fct.2008.11.037. Epub 2008 Dec 7.

PMID:
19100306
6.

Aqueous kava extracts do not affect liver function tests in rats.

Singh YN, Devkota AK.

Planta Med. 2003 Jun;69(6):496-9.

PMID:
12865965
7.

Hepatocellular toxicity of kava leaf and root extracts.

Lüde S, Török M, Dieterle S, Jäggi R, Büter KB, Krähenbühl S.

Phytomedicine. 2008 Jan;15(1-2):120-31. Epub 2007 Dec 4.

PMID:
18055189
8.

Prolonged ethanol administration depletes mitochondrial DNA in MnSOD-overexpressing transgenic mice, but not in their wild type littermates.

Larosche I, Choumar A, Fromenty B, Lettéron P, Abbey-Toby A, Van Remmen H, Epstein CJ, Richardson A, Feldmann G, Pessayre D, Mansouri A.

Toxicol Appl Pharmacol. 2009 Feb 1;234(3):326-38. doi: 10.1016/j.taap.2008.11.004. Epub 2008 Nov 20.

PMID:
19063909
9.

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ.

Planta Med. 2002 Dec;68(12):1055-8.

PMID:
12494328
10.

Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.

Mathews JM, Etheridge AS, Valentine JL, Black SR, Coleman DP, Patel P, So J, Burka LT.

Drug Metab Dispos. 2005 Oct;33(10):1555-63. Epub 2005 Jul 20.

11.

Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract.

Clayton NP, Yoshizawa K, Kissling GE, Burka LT, Chan PC, Nyska A.

Exp Toxicol Pathol. 2007 Jan;58(4):223-36. Epub 2006 Oct 23.

12.

Re-introduction of kava (Piper methysticum) to the EU: is there a way forward?

Sarris J, Teschke R, Stough C, Scholey A, Schweitzer I.

Planta Med. 2011 Jan;77(2):107-10. doi: 10.1055/s-0030-1250290. Epub 2010 Sep 2.

PMID:
20814850
13.

Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.).

Anke J, Ramzan I.

J Ethnopharmacol. 2004 Aug;93(2-3):153-60. Review.

PMID:
15234747
14.

Composition and biological activity of traditional and commercial kava extracts.

Côté CS, Kor C, Cohen J, Auclair K.

Biochem Biophys Res Commun. 2004 Sep 10;322(1):147-52.

PMID:
15313185
15.

Inhibition of human cytochrome P450 activities by kava extract and kavalactones.

Mathews JM, Etheridge AS, Black SR.

Drug Metab Dispos. 2002 Nov;30(11):1153-7.

16.

Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.

Otani K, Korenaga M, Beard MR, Li K, Qian T, Showalter LA, Singh AK, Wang T, Weinman SA.

Gastroenterology. 2005 Jan;128(1):96-107.

PMID:
15633127
17.

Kava kava: examining new reports of toxicity.

Clouatre DL.

Toxicol Lett. 2004 Apr 15;150(1):85-96. Review.

PMID:
15068826
18.

Gene expression profiling in male B6C3F1 mouse livers exposed to kava identifies--changes in drug metabolizing genes and potential mechanisms linked to kava toxicity.

Guo L, Shi Q, Dial S, Xia Q, Mei N, Li QZ, Chan PC, Fu P.

Food Chem Toxicol. 2010 Feb;48(2):686-96. doi: 10.1016/j.fct.2009.11.050. Epub 2009 Dec 3.

19.

Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1.

Lu Y, Cederbaum AI.

Toxicol Sci. 2006 Feb;89(2):515-23. Epub 2005 Oct 26.

PMID:
16251482
20.

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