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Items: 1 to 20 of 197

1.
2.

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2-7 hexamer dimerization.

Evrin C, Fernández-Cid A, Zech J, Herrera MC, Riera A, Clarke P, Brill S, Lurz R, Speck C.

Nucleic Acids Res. 2013 Mar 1;41(5):3162-72. doi: 10.1093/nar/gkt043. Epub 2013 Feb 1.

3.

An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer assembly.

Fernández-Cid A, Riera A, Tognetti S, Herrera MC, Samel S, Evrin C, Winkler C, Gardenal E, Uhle S, Speck C.

Mol Cell. 2013 May 23;50(4):577-88. doi: 10.1016/j.molcel.2013.03.026. Epub 2013 Apr 18.

4.

ATPase-dependent cooperative binding of ORC and Cdc6 to origin DNA.

Speck C, Chen Z, Li H, Stillman B.

Nat Struct Mol Biol. 2005 Nov;12(11):965-71.

5.

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication.

Chang F, Riera A, Evrin C, Sun J, Li H, Speck C, Weinreich M.

Elife. 2015 Aug 25;4. doi: 10.7554/eLife.05795.

6.

Sequential ATP hydrolysis by Cdc6 and ORC directs loading of the Mcm2-7 helicase.

Randell JC, Bowers JL, Rodríguez HK, Bell SP.

Mol Cell. 2006 Jan 6;21(1):29-39.

7.

Analysis of mutant origin recognition complex with reduced ATPase activity in vivo and in vitro.

Takehara M, Makise M, Takenaka H, Asano T, Mizushima T.

Biochem J. 2008 Aug 1;413(3):535-43. doi: 10.1042/BJ20070484.

PMID:
18393942
8.
9.

Origin licensing requires ATP binding and hydrolysis by the MCM replicative helicase.

Coster G, Frigola J, Beuron F, Morris EP, Diffley JF.

Mol Cell. 2014 Sep 4;55(5):666-77. doi: 10.1016/j.molcel.2014.06.034. Epub 2014 Jul 31.

10.

The dynamics of eukaryotic replication initiation: origin specificity, licensing, and firing at the single-molecule level.

Duzdevich D, Warner MD, Ticau S, Ivica NA, Bell SP, Greene EC.

Mol Cell. 2015 May 7;58(3):483-94. doi: 10.1016/j.molcel.2015.03.017. Epub 2015 Apr 23.

11.

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA.

Sun J, Evrin C, Samel SA, Fernández-Cid A, Riera A, Kawakami H, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2013 Aug;20(8):944-51. doi: 10.1038/nsmb.2629. Epub 2013 Jul 14.

12.

Dynamics of pre-replicative complex assembly.

Tsakraklides V, Bell SP.

J Biol Chem. 2010 Mar 26;285(13):9437-43. doi: 10.1074/jbc.M109.072504. Epub 2010 Jan 22.

13.

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation.

Evrin C, Fernández-Cid A, Riera A, Zech J, Clarke P, Herrera MC, Tognetti S, Lurz R, Speck C.

Nucleic Acids Res. 2014 Feb;42(4):2257-69. doi: 10.1093/nar/gkt1148. Epub 2013 Nov 14.

14.

Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.

Yuan Z, Riera A, Bai L, Sun J, Nandi S, Spanos C, Chen ZA, Barbon M, Rappsilber J, Stillman B, Speck C, Li H.

Nat Struct Mol Biol. 2017 Mar;24(3):316-324. doi: 10.1038/nsmb.3372. Epub 2017 Feb 13.

PMID:
28191893
15.

Cyclin A-dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis.

Findeisen M, El-Denary M, Kapitza T, Graf R, Strausfeld U.

Eur J Biochem. 1999 Sep;264(2):415-26.

16.

Epstein-Barr nuclear antigen 1 (EBNA1)-dependent recruitment of origin recognition complex (Orc) on oriP of Epstein-Barr virus with purified proteins: stimulation by Cdc6 through its direct interaction with EBNA1.

Moriyama K, Yoshizawa-Sugata N, Obuse C, Tsurimoto T, Masai H.

J Biol Chem. 2012 Jul 6;287(28):23977-94. doi: 10.1074/jbc.M112.368456. Epub 2012 May 14.

17.

Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.

Chen S, de Vries MA, Bell SP.

Genes Dev. 2007 Nov 15;21(22):2897-907.

18.

Biochemical analysis of components of the pre-replication complex of Archaeoglobus fulgidus.

Grainge I, Scaife S, Wigley DB.

Nucleic Acids Res. 2003 Aug 15;31(16):4888-98.

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