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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.

Scehnet JS, Jiang W, Kumar SR, Krasnoperov V, Trindade A, Benedito R, Djokovic D, Borges C, Ley EJ, Duarte A, Gill PS.

Blood. 2007 Jun 1;109(11):4753-60. Epub 2007 Feb 20.


Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis.

Djokovic D, Trindade A, Gigante J, Badenes M, Silva L, Liu R, Li X, Gong M, Krasnoperov V, Gill PS, Duarte A.

BMC Cancer. 2010 Nov 23;10:641. doi: 10.1186/1471-2407-10-641.


Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

Noguera-Troise I, Daly C, Papadopoulos NJ, Coetzee S, Boland P, Gale NW, Lin HC, Yancopoulos GD, Thurston G.

Nature. 2006 Dec 21;444(7122):1032-7.


Delta-like 4 is indispensable in thymic environment specific for T cell development.

Hozumi K, Mailhos C, Negishi N, Hirano K, Yahata T, Ando K, Zuklys S, Holländer GA, Shima DT, Habu S.

J Exp Med. 2008 Oct 27;205(11):2507-13. doi: 10.1084/jem.20080134. Epub 2008 Sep 29.


Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.

Hellström M, Phng LK, Hofmann JJ, Wallgard E, Coultas L, Lindblom P, Alva J, Nilsson AK, Karlsson L, Gaiano N, Yoon K, Rossant J, Iruela-Arispe ML, Kalén M, Gerhardt H, Betsholtz C.

Nature. 2007 Feb 15;445(7129):776-80. Epub 2007 Jan 28.


Delta-like 4/Notch signaling and its therapeutic implications.

Yan M, Plowman GD.

Clin Cancer Res. 2007 Dec 15;13(24):7243-6. Review.


Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos.

Trindade A, Kumar SR, Scehnet JS, Lopes-da-Costa L, Becker J, Jiang W, Liu R, Gill PS, Duarte A.

Blood. 2008 Sep 1;112(5):1720-9. doi: 10.1182/blood-2007-09-112748. Epub 2008 Jun 17.


Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.

Adam MG, Berger C, Feldner A, Yang WJ, Wüstehube-Lausch J, Herberich SE, Pinder M, Gesierich S, Hammes HP, Augustin HG, Fischer A.

Circ Res. 2013 Nov 8;113(11):1206-18. doi: 10.1161/CIRCRESAHA.113.301686. Epub 2013 Sep 11.


DLL4-Notch signaling mediates tumor resistance to anti-VEGF therapy in vivo.

Li JL, Sainson RC, Oon CE, Turley H, Leek R, Sheldon H, Bridges E, Shi W, Snell C, Bowden ET, Wu H, Chowdhury PS, Russell AJ, Montgomery CP, Poulsom R, Harris AL.

Cancer Res. 2011 Sep 15;71(18):6073-83. doi: 10.1158/0008-5472.CAN-11-1704. Epub 2011 Jul 29.


Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli.

Benedito R, Trindade A, Hirashima M, Henrique D, da Costa LL, Rossant J, Gill PS, Duarte A.

BMC Dev Biol. 2008 Dec 16;8:117. doi: 10.1186/1471-213X-8-117.


The Dll4/Notch pathway controls postangiogenic blood vessel remodeling and regression by modulating vasoconstriction and blood flow.

Lobov IB, Cheung E, Wudali R, Cao J, Halasz G, Wei Y, Economides A, Lin HC, Papadopoulos N, Yancopoulos GD, Wiegand SJ.

Blood. 2011 Jun 16;117(24):6728-37. doi: 10.1182/blood-2010-08-302067. Epub 2011 Apr 15.


Endothelial-specific Notch blockade inhibits vascular function and tumor growth through an eNOS-dependent mechanism.

Patenaude A, Fuller M, Chang L, Wong F, Paliouras G, Shaw R, Kyle AH, Umlandt P, Baker JH, Diaz E, Tong J, Minchinton AI, Karsan A.

Cancer Res. 2014 May 1;74(9):2402-11. doi: 10.1158/0008-5472.CAN-12-4038. Epub 2014 Mar 5.


Notch signaling regulates tumor angiogenesis by diverse mechanisms.

Dufraine J, Funahashi Y, Kitajewski J.

Oncogene. 2008 Sep 1;27(38):5132-7. doi: 10.1038/onc.2008.227. Review.


The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions.

Hainaud P, Contrerès JO, Villemain A, Liu LX, Plouët J, Tobelem G, Dupuy E.

Cancer Res. 2006 Sep 1;66(17):8501-10.


The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development.

Niessen K, Zhang G, Ridgway JB, Chen H, Kolumam G, Siebel CW, Yan M.

Blood. 2011 Aug 18;118(7):1989-97. doi: 10.1182/blood-2010-11-319129. Epub 2011 Jun 23.


The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development.

Seo S, Fujita H, Nakano A, Kang M, Duarte A, Kume T.

Dev Biol. 2006 Jun 15;294(2):458-70. Epub 2006 Apr 3.


Insulin-like growth factor binding protein-3 induces angiogenesis through IGF-I- and SphK1-dependent mechanisms.

Granata R, Trovato L, Lupia E, Sala G, Settanni F, Camussi G, Ghidoni R, Ghigo E.

J Thromb Haemost. 2007 Apr;5(4):835-45. Epub 2007 Feb 9.


Notch signaling: distinct ligands induce specific signals during lymphocyte development and maturation.

de La Coste A, Freitas AA.

Immunol Lett. 2006 Jan 15;102(1):1-9. Epub 2005 Jul 18. Review.


Mechanisms of angiogenesis.

Karamysheva AF.

Biochemistry (Mosc). 2008 Jul;73(7):751-62. Review.

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