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Deletion of NEMO/IKKgamma in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma.

Luedde T, Beraza N, Kotsikoris V, van Loo G, Nenci A, De Vos R, Roskams T, Trautwein C, Pasparakis M.

Cancer Cell. 2007 Feb;11(2):119-32.


Inflammatory tales of liver cancer.

Hoffmann A, Xia Y, Verma IM.

Cancer Cell. 2007 Feb;11(2):99-101.


Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout.

Ehlken H, Krishna-Subramanian S, Ochoa-Callejero L, Kondylis V, Nadi NE, Straub BK, Schirmacher P, Walczak H, Kollias G, Pasparakis M.

Cell Death Differ. 2014 Nov;21(11):1721-32. doi: 10.1038/cdd.2014.83. Epub 2014 Jun 27.


NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis.

Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M.

Cancer Cell. 2015 Nov 9;28(5):582-98. doi: 10.1016/j.ccell.2015.10.001. Erratum in: Cancer Cell. 2015 Dec 14;28(6):830.


Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury.

Beraza N, Lüdde T, Assmus U, Roskams T, Vander Borght S, Trautwein C.

Gastroenterology. 2007 Jun;132(7):2504-17. Epub 2007 Apr 6.


The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor?

Seki E, Brenner DA.

J Hepatol. 2007 Aug;47(2):307-9. Epub 2007 May 29.


Hepatocyte-specific NEMO deletion promotes NK/NKT cell- and TRAIL-dependent liver damage.

Beraza N, Malato Y, Sander LE, Al-Masaoudi M, Freimuth J, Riethmacher D, Gores GJ, Roskams T, Liedtke C, Trautwein C.

J Exp Med. 2009 Aug 3;206(8):1727-37. doi: 10.1084/jem.20082152. Epub 2009 Jul 27.


HBx-induced NF-κB signaling in liver cells is potentially mediated by the ternary complex of HBx with p22-FLIP and NEMO.

Lim KH, Choi HS, Park YK, Park ES, Shin GC, Kim DH, Ahn SH, Kim KH.

PLoS One. 2013;8(3):e57331. doi: 10.1371/journal.pone.0057331. Epub 2013 Mar 4.


NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice.

Malato Y, Ehedego H, Al-Masaoudi M, Cubero FJ, Bornemann J, Gassler N, Liedtke C, Beraza N, Trautwein C.

Gastroenterology. 2012 Dec;143(6):1597-1608.e11. doi: 10.1053/j.gastro.2012.08.030. Epub 2012 Aug 23.


TAK1: Another mesh in the NF-κB - JNK controlled network causing hepatocellular carcinoma.

Greten FR.

J Hepatol. 2011 Sep;55(3):721-3. doi: 10.1016/j.jhep.2011.02.037. Epub 2011 May 10.


The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer.

Liedtke C, Trautwein C.

Eur J Cell Biol. 2012 Jun-Jul;91(6-7):582-9. doi: 10.1016/j.ejcb.2011.10.001. Epub 2011 Dec 6. Review.


Fas-associated death-domain protein inhibits TNF-alpha mediated NF-kappaB activation in cardiomyocytes.

Chao W, Shen Y, Li L, Zhao H, Meiler SE, Cook SA, Rosenzweig A.

Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H2073-80. Epub 2005 Jun 24.


NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage.

Wuerzberger-Davis SM, Nakamura Y, Seufzer BJ, Miyamoto S.

Oncogene. 2007 Feb 1;26(5):641-51. Epub 2006 Jul 24.


NEMO expression in human hepatocellular carcinoma and its association with clinical outcome.

Aigelsreiter A, Haybaeck J, Schauer S, Kiesslich T, Bettermann K, Griessbacher A, Stojakovic T, Bauernhofer T, Samonigg H, Kornprat P, Lackner C, Pichler M.

Hum Pathol. 2012 Jul;43(7):1012-9. doi: 10.1016/j.humpath.2011.08.009. Epub 2011 Dec 15.


Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients.

Ribeiro PS, Cortez-Pinto H, Solá S, Castro RE, Ramalho RM, Baptista A, Moura MC, Camilo ME, Rodrigues CM.

Am J Gastroenterol. 2004 Sep;99(9):1708-17.


Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury.

Cubero FJ, Zhao G, Nevzorova YA, Hatting M, Al Masaoudi M, Verdier J, Peng J, Schaefer FM, Hermanns N, Boekschoten MV, Grouls C, Gassler N, Kiessling F, Muller M, Davis RJ, Liedtke C, Trautwein C.

J Hepatol. 2015 Jan;62(1):140-9. doi: 10.1016/j.jhep.2014.08.029. Epub 2014 Aug 27.


Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.

Rudolph D, Yeh WC, Wakeham A, Rudolph B, Nallainathan D, Potter J, Elia AJ, Mak TW.

Genes Dev. 2000 Apr 1;14(7):854-62.


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