Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 243


Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2205-10. Epub 2007 Feb 6.


The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.

Liu FJ, Barchowsky A, Opresko PL.

PLoS One. 2010 Jun 16;5(6):e11152. doi: 10.1371/journal.pone.0011152.


Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

Opresko PL.

Mech Ageing Dev. 2008 Jan-Feb;129(1-2):79-90. Epub 2007 Oct 30. Review.


Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

Crabbe L, Verdun RE, Haggblom CI, Karlseder J.

Science. 2004 Dec 10;306(5703):1951-3.


WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Li B, Jog SP, Reddy S, Comai L.

Mol Cell Biol. 2008 Mar;28(6):1892-904. doi: 10.1128/MCB.01364-07. Epub 2008 Jan 22.


Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.

Bai Y, Murnane JP.

Hum Genet. 2003 Sep;113(4):337-47. Epub 2003 Jun 25.


WRN at telomeres: implications for aging and cancer.

Multani AS, Chang S.

J Cell Sci. 2007 Mar 1;120(Pt 5):713-21. Review.


Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.

Dhillon KK, Sidorova JM, Albertson TM, Anderson JB, Ladiges WC, Rabinovitch PS, Preston BD, Monnat RJ Jr.

DNA Repair (Amst). 2010 Jan 2;9(1):11-22. doi: 10.1016/j.dnarep.2009.09.013. Epub 2009 Nov 5.


Roles of the Werner syndrome RecQ helicase in DNA replication.

Sidorova JM.

DNA Repair (Amst). 2008 Nov 1;7(11):1776-86. doi: 10.1016/j.dnarep.2008.07.017. Epub 2008 Sep 6. Review.


[Utilization of Werner syndrome mouse model in studying premature aging and tumor].

Jia ST, Yang SH, Luo Y.

Yi Chuan. 2009 Aug;31(8):785-90. Review. Chinese.


The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.

Sharma A, Awasthi S, Harrod CK, Matlock EF, Khan S, Xu L, Chan S, Yang H, Thammavaram CK, Rasor RA, Burns DK, Skiest DJ, Van Lint C, Girard AM, McGee M, Monnat RJ Jr, Harrod R.

J Biol Chem. 2007 Apr 20;282(16):12048-57. Epub 2007 Feb 21.


The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures.

Barefield C, Karlseder J.

Nucleic Acids Res. 2012 Aug;40(15):7358-67. doi: 10.1093/nar/gks407. Epub 2012 May 10.


Role of Werner syndrome gene product helicase in carcinogenesis and in resistance to genotoxins by cancer cells.

Futami K, Ishikawa Y, Goto M, Furuichi Y, Sugimoto M.

Cancer Sci. 2008 May;99(5):843-8. doi: 10.1111/j.1349-7006.2008.00778.x. Epub 2008 Feb 26. Review.


Introduction of a normal human chromosome 8 corrects abnormal phenotypes of Werner syndrome cells immortalized by expressing an hTERT gene.

Ariyoshi K, Suzuki K, Goto M, Oshimura M, Ishizaki K, Watanabe M, Kodama S.

J Radiat Res. 2009 May;50(3):253-9. Epub 2009 Apr 25.


The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses.

Turaga RV, Paquet ER, Sild M, Vignard J, Garand C, Johnson FB, Masson JY, Lebel M.

Cell Cycle. 2009 Jul 1;8(13):2080-92. Epub 2009 Jul 5.


Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway.

Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S.

Genes Dev. 2005 Nov 1;19(21):2560-70.


TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.

Machwe A, Xiao L, Orren DK.

Oncogene. 2004 Jan 8;23(1):149-56.


Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.

Oshima J, Sidorova JM, Monnat RJ Jr.

Ageing Res Rev. 2017 Jan;33:105-114. doi: 10.1016/j.arr.2016.03.002. Epub 2016 Mar 15. Review.


WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair.

Chen L, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J.

Aging Cell. 2003 Aug;2(4):191-9.


Supplemental Content

Support Center