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Chk1 is required for spindle checkpoint function.

Zachos G, Black EJ, Walker M, Scott MT, Vagnarelli P, Earnshaw WC, Gillespie DA.

Dev Cell. 2007 Feb;12(2):247-60.


The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint.

Hauf S, Cole RW, LaTerra S, Zimmer C, Schnapp G, Walter R, Heckel A, van Meel J, Rieder CL, Peters JM.

J Cell Biol. 2003 Apr 28;161(2):281-94. Epub 2003 Apr 21.


Chk1: a double agent in cell cycle checkpoints.

Yu H.

Dev Cell. 2007 Feb;12(2):167-8.


Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments.

Petsalaki E, Zachos G.

J Cell Sci. 2013 Mar 1;126(Pt 5):1235-46. doi: 10.1242/jcs.119677. Epub 2013 Jan 15.


Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.

J Cell Biol. 2003 Apr 28;161(2):267-80.


Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.

Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS.

J Cell Sci. 2005 Aug 15;118(Pt 16):3639-52. Epub 2005 Jul 26.


Chk2 prevents mitotic exit when the majority of kinetochores are unattached.

Petsalaki E, Zachos G.

J Cell Biol. 2014 May 12;205(3):339-56. doi: 10.1083/jcb.201310071. Epub 2014 May 5.


Exercising restraints: role of Chk1 in regulating the onset and progression of unperturbed mitosis in vertebrate cells.

Zachos G, Gillespie DA.

Cell Cycle. 2007 Apr 1;6(7):810-3. Epub 2007 Apr 22. Review.


Phosphorylation at serine 331 is required for Aurora B activation.

Petsalaki E, Akoumianaki T, Black EJ, Gillespie DA, Zachos G.

J Cell Biol. 2011 Oct 31;195(3):449-66. doi: 10.1083/jcb.201104023. Epub 2011 Oct 24.


The inhibition of Aurora A abrogates the mitotic delay induced by microtubule perturbing agents.

Wysong DR, Chakravarty A, Hoar K, Ecsedy JA.

Cell Cycle. 2009 Mar 15;8(6):876-88. Epub 2009 Mar 21.


BubR1 is a spindle assembly checkpoint protein regulating meiotic cell cycle progression of mouse oocyte.

Wei L, Liang XW, Zhang QH, Li M, Yuan J, Li S, Sun SC, Ouyang YC, Schatten H, Sun QY.

Cell Cycle. 2010 Mar 15;9(6):1112-21. Epub 2010 Mar 15.


Raf kinase inhibitory protein regulates aurora B kinase and the spindle checkpoint.

Eves EM, Shapiro P, Naik K, Klein UR, Trakul N, Rosner MR.

Mol Cell. 2006 Aug;23(4):561-74.


Mitotic spindle checkpoint inactivation by trichostatin a defines a mechanism for increasing cancer cell killing by microtubule-disrupting agents.

Dowling M, Voong KR, Kim M, Keutmann MK, Harris E, Kao GD.

Cancer Biol Ther. 2005 Feb;4(2):197-206. Epub 2005 Feb 8.


U2OS cells lacking Chk1 undergo aberrant mitosis and fail to activate the spindle checkpoint.

Carrassa L, Sanchez Y, Erba E, Damia G.

J Cell Mol Med. 2009 Aug;13(8A):1565-76. doi: 10.1111/j.1582-4934.2009.00362.x.


Chking and executing cell division to prevent genomic instability.

Peddibhotla S, Rosen JM.

Cell Cycle. 2009 Aug;8(15):2339-42. Epub 2009 Aug 3.


EB1 enables spindle microtubules to regulate centromeric recruitment of Aurora B.

Banerjee B, Kestner CA, Stukenberg PT.

J Cell Biol. 2014 Mar 17;204(6):947-63. doi: 10.1083/jcb.201307119. Epub 2014 Mar 10.


Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase.

Foley EA, Maldonado M, Kapoor TM.

Nat Cell Biol. 2011 Aug 28;13(10):1265-71. doi: 10.1038/ncb2327.


Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.

Park I, Lee HO, Choi E, Lee YK, Kwon MS, Min J, Park PG, Lee S, Kong YY, Gong G, Lee H.

J Cell Biol. 2013 Jul 22;202(2):295-309. doi: 10.1083/jcb.201210099.


Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

van Leuken RJ, Luna-Vargas MP, Sixma TK, Wolthuis RM, Medema RH.

Cell Cycle. 2008 Sep 1;7(17):2710-9. Epub 2008 Sep 3.


The DNA-damage effector checkpoint kinase 1 is essential for chromosome segregation and cytokinesis.

Peddibhotla S, Lam MH, Gonzalez-Rimbau M, Rosen JM.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5159-64. doi: 10.1073/pnas.0806671106. Epub 2009 Mar 16.

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