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Items: 1 to 20 of 77

1.

A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine.

Sang TK, Chang HY, Lawless GM, Ratnaparkhi A, Mee L, Ackerson LC, Maidment NT, Krantz DE, Jackson GR.

J Neurosci. 2007 Jan 31;27(5):981-92.

2.

Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities.

Wang C, Lu R, Ouyang X, Ho MW, Chia W, Yu F, Lim KL.

J Neurosci. 2007 Aug 8;27(32):8563-70.

3.

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW.

J Neurosci. 2009 Feb 18;29(7):1962-76. doi: 10.1523/JNEUROSCI.5351-08.2009.

4.

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.

Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B.

Neuron. 2003 Mar 27;37(6):911-24.

5.

Overexpression of Septin 4, the Drosophila homologue of human CDCrel-1, is toxic for dopaminergic neurons.

Muñoz-Soriano V, Paricio N.

Eur J Neurosci. 2007 Dec;26(11):3150-8.

PMID:
18028112
6.

Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin.

Yang Y, Gehrke S, Imai Y, Huang Z, Ouyang Y, Wang JW, Yang L, Beal MF, Vogel H, Lu B.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10793-8. Epub 2006 Jul 3.

7.

Parkin counteracts symptoms in a Drosophila model of Parkinson's disease.

Haywood AF, Staveley BE.

BMC Neurosci. 2004 Apr 16;5:14.

8.

Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease.

Whitworth AJ, Theodore DA, Greene JC, Benes H, Wes PD, Pallanck LJ.

Proc Natl Acad Sci U S A. 2005 May 31;102(22):8024-9. Epub 2005 May 23.

9.

Folic acid supplementation rescues anomalies associated with knockdown of parkin in dopaminergic and serotonergic neurons in Drosophila model of Parkinson's disease.

Srivastav S, Singh SK, Yadav AK, Srikrishna S.

Biochem Biophys Res Commun. 2015 May 8;460(3):780-5. doi: 10.1016/j.bbrc.2015.03.106. Epub 2015 Mar 27.

PMID:
25824034
10.

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin.

Park J, Lee SB, Lee S, Kim Y, Song S, Kim S, Bae E, Kim J, Shong M, Kim JM, Chung J.

Nature. 2006 Jun 29;441(7097):1157-61. Epub 2006 May 3.

PMID:
16672980
11.
12.

Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein.

Park SS, Schulz EM, Lee D.

Eur J Neurosci. 2007 Dec;26(11):3104-12. Epub 2007 Nov 14.

PMID:
18005066
13.

Dopamine-dependent neurodegeneration in Drosophila models of familial and sporadic Parkinson's disease.

Bayersdorfer F, Voigt A, Schneuwly S, Botella JA.

Neurobiol Dis. 2010 Oct;40(1):113-9. doi: 10.1016/j.nbd.2010.02.012. Epub 2010 Mar 6.

PMID:
20211259
14.

Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.

Ng CH, Mok SZ, Koh C, Ouyang X, Fivaz ML, Tan EK, Dawson VL, Dawson TM, Yu F, Lim KL.

J Neurosci. 2009 Sep 9;29(36):11257-62. doi: 10.1523/JNEUROSCI.2375-09.2009.

15.

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells.

Jiang H, Ren Y, Yuen EY, Zhong P, Ghaedi M, Hu Z, Azabdaftari G, Nakaso K, Yan Z, Feng J.

Nat Commun. 2012 Feb 7;3:668. doi: 10.1038/ncomms1669.

16.

Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1.

Dong Z, Ferger B, Paterna JC, Vogel D, Furler S, Osinde M, Feldon J, Büeler H.

Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12438-43. Epub 2003 Oct 6.

17.

Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila.

Cha GH, Kim S, Park J, Lee E, Kim M, Lee SB, Kim JM, Chung J, Cho KS.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10345-50. Epub 2005 Jul 7.

18.

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.

Jiang H, Ren Y, Zhao J, Feng J.

Hum Mol Genet. 2004 Aug 15;13(16):1745-54. Epub 2004 Jun 15.

PMID:
15198987
19.

Parkin suppresses c-Jun N-terminal kinase-induced cell death via transcriptional regulation in Drosophila.

Hwang S, Kim D, Choi G, An SW, Hong YK, Suh YS, Lee MJ, Cho KS.

Mol Cells. 2010 Jun;29(6):575-80. doi: 10.1007/s10059-010-0068-1. Epub 2010 May 22.

20.

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin.

Clark IE, Dodson MW, Jiang C, Cao JH, Huh JR, Seol JH, Yoo SJ, Hay BA, Guo M.

Nature. 2006 Jun 29;441(7097):1162-6. Epub 2006 May 3.

PMID:
16672981

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